Specific binding agents of human angiopoietin-2
Disclosed are peptides that bind to Ang-2. Also disclosed are peptibodies comprising the peptides, methods of making such peptides and peptibodies, and methods of treatment using such peptides and peptibodies.
1. A polypeptide capable of binding Ang-2 said polypeptide comprising the amino acid sequence: (SEQ ID NO: 25), and physiologically acceptable salts thereof.
2. The polypeptide according to claim 1 wherein Fc in SEQ ID NO:25 is the human Fc IgG1 sequence.
3. The polypeptide according to claim 2 wherein the amino acid sequence of the Fc in SEQ ID NO:25 is set forth in SEQ ID NO:60.
4. A pharmaceutical composition comprising an effective amount of a polypeptide according to any one of claims 1 - 3 in admixture with a pharmaceutically acceptable carrier thereof.