Calcium phosphate complex and salts in oral delivery systems
The present invention relates to oral delivery systems, such as confectionery and chewing gum compositions, and methods for remineralizing tooth enamel in mammals. In particular, the oral delivery systems include a phosphopeptide or phosphoprotein stabilized calcium phosphate or calcium fluoride phosphate complex and a salt selected from calcium salts, phosphate salts and combinations thereof. The delivery systems promote remineralization of tooth enamel of consumers.
1. An oral delivery system comprising:
(a) a casein phosphopeptide-calcium phosphate complex; and
(b) a calcium salt and a phosphate salt, wherein each of said salts is a separate and additional component from said complex, and wherein said calcium salt is selected from the group consisting of calcium chloride, calcium lactate, calcium sulfate, calcium carbonates, calcium phosphates, calcium glutareate, calcium malate, calcium citrate, calcium gluconate, calcium glycerophosphate, calcium fumarate, calcium hydroxide, calcium oxide and combinations thereof, and said phosphate salt is selected from the group consisting of neutral, monobasic and dibasic sodium phosphate salts; and
wherein said oral delivery system is a sugar-containing chewing gum or confectionery;
wherein said casein phosphopeptide calcium phosphate complex is present in an amount that is less by weight than that of said salts, and said casein phosphopeptide calcium phosphate complex is present in an amount of from about 0.1% to about 0.5% by weight of said system, said calcium salt is present in an amount of from about 1.5% to about 3.0% by weight of said system, and said phosphate salt is present in an amount of from 1.2% to about 1.8% by weight of said system; and
wherein upon consumption said system provides a level of enamel subsurface remineralization in the tooth of a mammal that is at least about 12.5% greater than the amount of remineralization provided by consumption of a composition which is substantially the same as said system but which is free of said complex and said salts.
2. The oral delivery system of claim 1 , wherein said calcium salt is calcium lactate.
3. The oral delivery system of claim 1 , wherein said system is a chewing gum.
4. The oral delivery system of claim 1 , wherein said system is free of added sodium bicarbonate.