Chelator-modified inorganic oxide particles
The present invention is directed to inorganic oxide particles that have been modified with a chelator group. In an embodiment, the chelator group is covalently bonded to a polymer. In an embodiment, the chelator group is covalently bonded to a chiral selector ligand. The present invention is also directed to methods of modifying inorganic oxide particles with a chelator group.
1. A particle for use in chromatography columns comprising:
an inorganic oxide core,
a cross-linked polymer coating surrounding the inorganic oxide core, and
a chelator bonding the cross-linked polymer to the inorganic oxide core, the chelator covalently bonded to the cross-linked polymer.
2. The particle of claim 1 , wherein the inorganic oxide core is selected from the group consisting of zirconia, titania, and silica.
3. The particle of claim 2 , wherein the inorganic oxide core is zirconia.
4. The particle of claim 1 , wherein the inorganic oxide core is porous.
5. The particle of claim 4 , wherein the pore sizes range from 50-2000 angstroms.
6. The particle of claim 1 , wherein the inorganic oxide core is non-porous.
7. The particle of claim 1 , wherein the inorganic oxide core ranges from 1-100 microns in diameter.
8. The particle of claim 1 , wherein the cross-linked polymer is hydrophobic.
9. The particle of claim 8 , wherein the cross-linked polymer is polybutadiene (PBD).
10. The particle of claim 1 , wherein the cross-linked polymer is hydrophilic.
11. The particle of claim 10 , wherein the hydrophilic polymer is selected from the group consisting of polyvinylalcohol, poly(ethyleneglycol), polyvinylpyrollidone, polyethyleneimine, poly(butadiene maleic acid), polysiloxane, and poly-1-histidine, and dextran.
12. The particle of claim 1 , wherein the chelator has at least one Lewis base site selected from the group consisting of OH, COOH, COOR, PO 3 H, PO 2 H, POH, SiH, SiCl.
13. The particle of claim 12 , wherein the chelator has another reactive moiety selected from the group consisting of OH, NH, NH 2 , COOH, and a double bond.
14. The particle of claim 1 , wherein the chelator is EDTPA (N,N,N′,N′-ethylenediaminetetra(methylenephosphonic acid)).
15. The particle of claim 1 , wherein the chelator is PEI (poly(ethyleneimine)).
16. The particle of claim 1 , further comprising a carbon cladding on the inorganic oxide core.
17. The particle of claim 1 , wherein the particle is a spherule.
18. The particle of claim 1 , wherein the particle is a monolith.