Nucleic acids and proteins from
View Patent ↗The invention provides proteins from group B streptococcus ( Streptococcus agalactiae ) and group A streptococcus ( Streptococcus pyogenes ), including amino acid sequences and the corresponding nucleotide sequences. Data are given to show that the proteins are useful antigens for vaccines, immunogenic compositions, and/or diagnostics. The proteins are also targets for antibiotics.
1. An immunogenic S. agalactiae protein in substantially pure form comprising a fragment of 100 or more consecutive amino acids from the amino acid sequence SEQ ID NO:3746, wherein the protein binds to specific antibodies raised against an S. agalactiae protein comprising the amino acid sequence SEQ ID NO:3746, wherein the specific antibodies do not bind to unrelated antigens, and wherein the immunogenic S. agalactiae protein is an isolated protein or a recombinant protein.
2. The immunogenic S. agalactiae protein of claim 1 which is the isolated protein.
3. The immunogenic S. agalactiae protein of claim 1 which is the recombinant protein.
4. A composition comprising:
an immunogenic S. agalactiae protein in substantially pure form comprising a fragment of 100 or more consecutive amino acids from the amino acid sequence SEQ ID NO:3746, wherein the protein binds to specific antibodies raised against an S. agalactiae protein comprising the amino acid sequence SEQ ID NO:3746, wherein the specific antibodies do not bind to unrelated antigens; and
an adjuvant.
5. The composition of claim 4 which comprises a pharmaceutically acceptable carrier.
6. The composition of claim 4 , wherein the immunogenic S. agalactiae protein is a recombinant protein.
7. The composition of claim 6 , further comprising a pharmaceutically acceptable carrier.
8. The composition of claim 4 , wherein the adjuvant comprises an aluminium salt.
9. The composition of claim 8 wherein the aluminium salt is alum.
10. The composition of claim 4 , wherein the adjuvant comprises squalene, polyoxyethylene sorbitan monooleate, and sorbitan trioleate.
11. The composition of claim 5 , wherein the adjuvant comprises an aluminium salt.
12. The composition of claim 11 wherein the aluminium salt is alum.
13. The composition of claim 5 , wherein the adjuvant comprises squalene, polyoxyethylene sorbitan monooleate, and sorbitan trioleate.
14. The composition of claim 4 , wherein the immunogenic S. agalactiae protein is an isolated protein.
15. The composition of claim 6 , wherein the adjuvant comprises an aluminium salt.
16. The composition of claim 15 , wherein the aluminium salt is alum.
17. The composition of claim 6 , wherein the adjuvant comprises squalene, polyoxyethylene sorbitan monooleate, and sorbitan trioleate.
18. The composition of claim 14 , wherein the adjuvant comprises an aluminium salt.
19. The composition of claim 18 , wherein the aluminium salt is alum.
20. The composition of claim 14 , wherein the adjuvant comprises squalene, polyoxyethylene sorbitan monooleate, and sorbitan trioleate.