Treatment of skin, and wound repair, with thymosin beta 4
Compositions and methods for treatment of skin utilizing thymosin β4.
1. A composition for topical administration to skin, comprising a tissue regeneration promoting amount of human thymosin β4 of SEQ ID NO:3; human transforming growth factor β1, and a pharmaceutically acceptable topical vehicle.
2. A composition for topical administration to skin comprising a tissue regeneration promoting amount of human thymosin β4 of SEQ ID NO:3; human vascular endothelial growth factor and a pharmaceutically acceptable topical vehicle.
3. The composition according to claim 2 , wherein said vehicle is an oil in water, or water in oil emulsion.
4. A method for improving damage to the skin, the method comprising:
applying topically to said damaged skin a composition comprising a tissue regeneration promoting amount of human thymosin β4 of SEQ ID NO:3; and a pharmaceutically acceptable topical vehicle.
5. A method for improving damage to the skin, the method comprising:
applying topically a composition comprising a tissue regeneration promoting amount of human thymosin β4 of SEQ ID NO:3, human transforming growth factor β1, and a pharmaceutically acceptable topical vehicle.
6. A method for improving damage to the skin, the method comprising:
applying topically a composition comprising a tissue regeneration promoting amount of human thymosin β4 of SEQ ID NO:3, human vascular endothelial growth factor, and a pharmaceutically acceptable topical vehicle.
7. The method according to claim 6 , wherein said skin damaged by irradiation or contains scar tissue.
8. The method according to claim 7 , wherein said cosmetically acceptable vehicle is an oil in water, or water in oil emulsion.
9. A composition for topical treatment of skin, comprising a thymosin beta 4 of SEQ ID NO:3 and a vehicle acceptable for topical administration, further comprising transforming growth factor beta, vascular endothelial growth factor, or both.
10. The composition of claim 9 , further comprising transforming growth factor beta.
11. The composition of claim 10 , wherein said transforming growth factor beta is transforming growth factor beta 1.
12. The composition of claim 9 , further comprising vascular endothelial growth factor.
13. The composition of claim 9 , wherein said vehicle is a lotion, cream, suspension, dispersion or oil.
14. A method of treating damaged skin tissue in a subject comprising topically administering the composition of claim 9 , to said subject.
15. A method of regenerating or revitalizing skin tissue in a subject comprising topically administering the composition of claim 9 , to said subject.
16. The method of claim 14 , wherein said vehicle is a lotion, cream, suspension, dispersion or oil.
17. The composition of claim 1 wherein said skin is in need of repair.
18. The composition of claim 2 wherein said skin is in need of repair.
19. The method of claim 4 wherein said skin is in need of repair.
20. The method of claim 5 wherein said skin is in need of repair.
21. The method of claim 6 wherein said skin is in need of repair.