IP Library › Granted Patent US 8,143,259

Granted Patent B2

US 8,143,259 · App. 12/539,267 · Granted Mar 27, 2012

Cold menthol receptor antagonists

Assignee: Janssen Pharmaceutica, NV

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Patent No.: US 8,143,259
App. No.: 12/539,267
Granted: Mar 27, 2012
Kind: B2

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Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, L, Q, R 1 , R 2 , and R 3 are defined herein.

Claims (1036)

1. A compound of Formula (I)

wherein

A is phenyl; or, when A is phenyl, L is —(CH 2 ) m N(R 4 )(CH 2 ) n —, and R 1 and L are attached to adjacent carbon atoms of phenyl, R 1 and R 4 are optionally taken with the atoms to which they are attached to form dihydroindolyl;

R 1 is one to two substituents independently selected from the group consisting of hydrogen, C 1-2 alkyl, C 1-2 alkoxy, methoxycarbonyl, and fluoro;

B is selected from the group consisting of phenyl, benzothiophenyl, azabenzothiophenyl, benzothiazolyl, unsubstituted quinolinyl, dihydrobenzofuranyl, and substituted pyridinyl;

R 2 is a substituent independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkoxy, chloro, bromo, and cyano;

and R 2 is optionally one additional substituent selected from the group consisting of C 1-4 alkoxycarbonyl, methylcarbonylamino, trifluoromethyl, phenyl optionally substituted with 4-carboxy, pyrimidin-5-yl, N-morpholinyl, piperidinyl, pyridinyl, imidazolyl, 4-(3,6-dihydro-2H-pyridin-4-yl) optionally substituted at nitrogen with t-butoxycarbonyl, and hydroxymethyl;

L is —(CH 2 ) m -Z-(CH 2 ) n — or —CH 2 —; wherein m and n are independently 0 or 1, such that the sum of m+n is no greater than 1; and Z is NR 4 ;

R 3 is hydrogen;

R 4 is hydrogen or methyl;

Q is

wherein

X is a direct bond;

p is 1;

and D, E, H, and J are benzo or pyrido;

W is phenyl or a heteroaryl selected from the group consisting of pyridinyl, thiazolyl, furanyl, and thienyl; wherein phenyl of W is optionally substituted with one to two substituents independently selected from the group consisting of C 1-4 alkyl, C 1-4 alkoxy, hydroxymethyl, fluoro, chloro, bromo, amino, di(C 1-4 alkyl)amino, C 1-4 alkoxycarbonyl, C 1-4 alkylcarbonylamino, carboxy, and trifluoromethyl; and

wherein pyridinyl of W is optionally substituted with bromo;

V is hydrogen, C 1-2 alkoxycarbonyl or hydroxymethyl; and

R 5a and R 5b are hydrogen;

R 8 is hydrogen and R 10 is phenyl or pyridinyl; or R 8 is phenyl and R 10 is hydrogen;

R 11 is hydrogen or hydroxy;

R 9 , R 12 , R 13 , and R 14 are independently selected from the group consisting of hydrogen or methyl;

provided that a compound of Formula (I) is other than

a compound wherein A is phenyl, R 1 is 2-fluoro, B is phenyl, R 2 is 4-bromo, L is —(CH 2 ) m -Z-(CH 2 ) n —, m and n are 0, Z is NR 4 , R 3 is hydrogen, R 4 is hydrogen, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is hydrogen, and R 5a and R 5b are hydrogen;

a compound wherein A is phenyl, R 1 is 2-fluoro, B is phenyl, R 2 is 4-chloro, L is —(CH 2 ) m -Z-(CH 2 ) n —, m and n are 0, Z is NR 4 , R 3 is hydrogen, R 4 is hydrogen, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is hydrogen, and R 5a and R 5b are hydrogen;

a compound wherein A is phenyl, R 1 is 2-fluoro, B is quinolin-3-yl, R 2 is hydrogen, L is —(CH 2 ) m -Z-(CH 2 ) n —, m and n are 0, Z is NR 4 , R 3 is hydrogen, R 4 is hydrogen, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is hydrogen, and R 5a and R 5b are hydrogen;

a compound wherein A is phenyl, R 1 is 3,4-difluoro, B is benzothiophen-2-yl, R 2 is 3-methyl, L is —CH 2 —, R 3 is hydrogen, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is hydrogen, and R 5a and R 5b are hydrogen;

and

and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.

2. A compound of Formula (I)

wherein

R 1 is one to two substituents independently selected from the group consisting of hydrogen, methoxycarbonyl, methoxy, and fluoro; B is selected from the group consisting of phenyl, benzothiophenyl, azabenzothiophenyl, benzothiazolyl, unsubstituted quinolinyl, dihydrobenzofuranyl, and substituted pyridinyl;

R 2 is a substituent selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkoxy, chloro, bromo, cyano, C 1-4 alkoxycarbonyl, methylcarbonylamino, trifluoromethyl, phenyl optionally substituted with 4-carboxy, pyrimidin-5-yl, N-morpholinyl, piperidinyl, pyridinyl, imidazolyl, 4-(3,6-dihydro-2H-pyridin-4-yl) substituted at nitrogen with t-butoxycarbonyl, and hydroxymethyl;

L is —(CH 2 ) m -Z-(CH 2 ) n — or —CH 2 —; wherein m and n are 0, and Z is NR 4 ;

R 3 is hydrogen;

R 4 is hydrogen or methyl;

Q is

wherein

X is a direct bond;

p is 1;

and D, E, and J are benzo;

W is phenyl or a heteroaryl selected from the group consisting of pyridinyl, thiazolyl, furanyl, and thienyl; wherein phenyl of W is optionally substituted with a substituent selected from the group consisting of C 1-2 alkyl, C 1-2 alkoxy, hydroxymethyl, fluoro, chloro, bromo, amino, di(C 1-4 alkyl)amino, C 1-2 alkoxycarbonyl, C 1-4 alkylcarbonylamino, carboxy, and trifluoromethyl; and

wherein pyridinyl of W is optionally substituted with bromo;

V is hydrogen, C 1-2 alkoxycarbonyl or hydroxymethyl; and

R 5a and R 5b are hydrogen;

R 8 is hydrogen and R 10 is pyridinyl; or, R 8 is phenyl and R 10 is hydrogen;

R 11 is hydrogen or hydroxy;

R 9 , R 12 , R 13 , and R 14 are independently hydrogen;

provided that a compound of Formula (I) is other than

and

and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.

3. A compound of Formula (I)

wherein

R 1 is selected from the group consisting of hydrogen, methoxycarbonyl, 2-methoxy, fluoro, and di-fluoro; B is selected from the group consisting of phenyl, benzothiophenyl, azabenzothiophenyl, benzothiazolyl, unsubstituted quinolinyl, dihydrobenzofuranyl, and substituted pyridinyl;

R 2 is a substituent selected from the group consisting of hydrogen, C 1-4 alkyl, C 1-4 alkoxy, chloro, bromo, C 1-4 alkoxycarbonyl, methylcarbonylamino, trifluoromethyl, phenyl optionally substituted with 4-carboxy, pyrimidin-5-yl, N-morpholinyl, piperidinyl, pyridinyl, imidazolyl, 4-(3,6-dihydro-2H-pyridin-4-yl) substituted at nitrogen with t-butoxycarbonyl, and hydroxymethyl;

L is —(CH 2 ) m -Z-(CH 2 ) n — or —CH 2 —; wherein m and n are 0, and Z is NR 4 ;

R 3 is hydrogen;

R 4 is hydrogen or methyl;

Q is

wherein X is a direct bond and E and H are benzo;

wherein pyridinyl of W is optionally substituted with bromo;

V is hydrogen, C 1-2 alkoxycarbonyl or hydroxymethyl; and

R 5a and R 5b are hydrogen;

R 12 and R 13 are independently hydrogen;

provided that a compound of Formula (I) is other than

and

and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof.

4. A compound of Formula (I)

selected from the group consisting of

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-chloro-phenyl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-chloro-phenyl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenylamino-methyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is H, V is H, and R 5a is phenyl, and R 5b is H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is thien-2-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is indol-2-yl, V is H, and R 5a and R 5b are H (*RS,*RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is indol-2-yl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-4-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-bromo-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, is a direct bond, W is 2-trifluoromethyl-phenyl, V is H, and R 5a and R 5b are H (*RS,*RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-trifluoromethyl-phenyl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methyl-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,*R);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,*S);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,*S);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,*R);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is thiazol-2-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-2-yl, V is H, and R 5a and R 5b are H (*RS,*RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-2-yl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is furan-2-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 2-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-cyano, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-cyano, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is NH, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-methoxy, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-methoxy, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 3-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 3-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is methyl, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 1, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 1, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 3-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 3-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 3-cyano, A is thien-2-yl, R 2 is 4-methoxy, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,4-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,4-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,4-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,4-difluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-fluoro-phenyl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-fluoro-phenyl, V is H, and R 5a and R 5b are H (*RS,*RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-methoxy, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-methoxy, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 4-methoxy, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,*S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,*S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,*R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,*R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,*R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2,3-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2,3-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2,3-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*SR,*RS);

a compound of Formula (I) wherein R 1 is 2,3-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,5-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,5-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,5-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 3-methyl, B is benzothiophen-2-yl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-dimethylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-ethoxycarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-ethoxycarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is taken with R 1 to form a tetrahydroquinolin-2-yl, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-4-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-(1-hydroxy-1-methyl-ethyl, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is 0, L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-2-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is methoxycarbonyl, and R 5a and R 5b are H (*R,R);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is methoxycarbonyl, and R 5a and R 5b are H (*S,R);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is methoxycarbonyl, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is methoxycarbonyl, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is H, B is pyridin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is H, B is pyridin-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*SR,*RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-hydroxymethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-methoxycarbonyl-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-methoxycarbonyl-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-carboxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-carboxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-methanesulfonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is taken with R 1 to form 2,3-dihydroindol-1-yl, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is methyl, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is S-hydroxymethyl, and R 5a and R 5b are H (*S,R);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is phenyl, V is S-hydroxymethyl, and R 5a and R 5b are H (*R,R);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is N-methyl, B is indol-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2,3-difluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is 2,3-dihydro-benzofuran-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(pyridin-2-yl), B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS)

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-dimethylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-isopropylaminocarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-isopropylaminocarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is 0, L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-methylaminocarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-amino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-dimethylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-dimethylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-dimethylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is taken with R 1 to form a 2,3-dihydro-indol-1-yl, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is 2,3-dihydro-benzofuran-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is H, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-7-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(pyridin-3-yl), B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyrimidin-5-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-2-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-amino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is taken with R 1 to form 3,4-dihydro-2H-quinolin-1-yl, Q is q-1, X is a direct bond, W is phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-N-morpholino, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-4-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(4-carboxy)-phenyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(N-t-butoxycarbonyl-3,6-dihydro-2H-pyridin-4-yl), B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-3-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-imidazol-1-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(3,6-dihydro-2H-pyridin-4-yl), B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-amino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 2-phenyl, B is pyridin-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro-3-methoxycarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(3-carboxy)-phenyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 3-methoxycarbonyl, A is phenyl, R 2 is H, B is 2,3-dihydro-benzofuran-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*S,R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*R,R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-methylcarbonylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-methylcarbonylamino-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is methylcarbonyl, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H(S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is 2-thieno[2,3-b]pyridin-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-2-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-4-yl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-4-yl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-methoxycarbonyl-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-methoxycarbonyl-phenyl, V is H, and R 5 is H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-carboxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-carboxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-2-yl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-2-yl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is 2-isoquinolin-4-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 2-N-piperidinyl, B is pyridin-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 2-N-piperidinyl, B is pyridin-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-methoxy-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-2-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-2-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 2-methyl, B is benzothiazol-6-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-imidazol-1-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-3-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 5-bromo-pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 5-bromo-pyridin-3-yl, V is H, and R 5a and R 5b are H (*SR,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 5-bromo-pyridin-3-yl, V is H, and R 5a and R 5b are H (*RS,*SR);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-methoxycarbonyl-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-dimethylamino-phenyl, V is H, and R 5a and R 5b are H (RS,R);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 3-carboxy-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(4-carboxy)-phenyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is 2,3-dihydro-benzofuran-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H,

R 4 is H, Q is q-1, X is a direct bond, W is 4-methoxycarbonyl-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-2-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-methoxycarbonyl-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-pyridin-2-yl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 4-carboxy-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-(4-1H-tetrazol-5-yl-phenyl), B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 6-t-butyl, B is pyridin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 2-N-morpholinyl, B is pyridin-5-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 2-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*S,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-chloro-phenyl, V is H, and R 5a and R 5b are H (*R,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-methylaminocarbonyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,S);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-2, X is a direct bond, R 7 is phenyl, s is 1, and R 6 is methyl (*RS,*SR);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-3, X is a direct bond, p is 1, R 8 is H, R 10 is phenyl, and R 11 is hydroxy (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-3, X is a direct bond, p is 1, R 8 is phenyl, R 10 is H, and R 11 is H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-3, X is a direct bond, p is 2, R 8 is phenyl, R 10 is H, and R 11 is H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-3, X is a direct bond, p is 1, R 8 is phenyl, R 10 is H, and R 11 is H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-3, X is NH, p is 2, R 8 is phenyl, R 10 is H, and R 11 is H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-t-butyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is 7-methyl (RS);

a compound of Formula (I) wherein R 1 is 2-methyl, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is 2,6-dimethyl, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is 2-chloro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is 3-chloro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is 4-chloro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 1, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is cyclohexyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is taken with R 1 to form 2,3-dihydroindol-1-yl, Q is q-4, X is a direct bond, D is benzo, and R 9 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-methoxy, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 3-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 4-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2,4-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 4-methoxy, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2,3-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2,5-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 3-methyl, B is benzothiophen-2-yl, L is —CH 2 —, R 3 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is taken with R 1 to form tetrahydroquinolin-2-yl, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, L is —CH 2 —, R 3 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is H, B is pyridin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is H, B is pyridin-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is methyl, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is benzothiophen-2-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is n/a, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is taken with R 1 to form 3,4-dihydro-2H-quinolin-1-yl, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is hydrogen, Q is q-6, X is a direct bond, H is benzo, and R 13 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is hydrogen, Q is q-6, X is a direct bond, H is benzo, and R 13 is H (RS);

a compound of Formula (I) wherein R 1 is 2,6-difluoro, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is hydrogen, Q is q-6, X is a direct bond, H is benzo, and R 13 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is H, B is quinolin-3-yl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-5, X is a direct bond, E is benzo, and R 12 is H (RS,S);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-7, X is a direct bond, J is benzo, and R 14 is H (RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-chloro, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-7, X is a direct bond, J is benzo, and R 14 is H (RS);

a compound of Formula (I) wherein R 1 is 2-fluoro, A is phenyl, R 2 is 4-bromo, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-7, X is a direct bond, J is benzo, and R 14 is H (RS);

and

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 1, n is 0, R 3 is H, R 4 is H, Q is q-7, X is a direct bond, J is benzo, and R 14 is H (RS);

and enantiomers, diastereomers, racemates, and pharmaceutically acceptable salts thereof.

5. A compound of Formula (I)

selected from the group consisting of

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-3-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-fluoro-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is thien-2-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is indol-2-yl, V is H, and R 5a and R 5b are H (*RS,*RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is pyridin-4-yl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-bromo-phenyl, V is H, and R 5a and R 5b are H (RS,RS);

a compound of Formula (I) wherein R 1 is H, A is phenyl, R 2 is 4-trifluoromethyl, B is phenyl, Z is NR 4 , L is —(CH 2 ) m -Z-(CH 2 ) n —, m is 0, n is 0, R 3 is H, R 4 is H, Q is q-1, X is a direct bond, W is 2-trifluoromethyl-phenyl, V is H, and R 5a and R 5b are H (*RS,*RS);