Antibacterial amide and sulfonamide substituted heterocyclic urea compounds

1. A compound of Formula (I):

in which:

R 1 is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl;

X is selected from the group consisting of a C and N atom;

Y is selected from the group consisting of CO and SO 2 ;

R 2 , R 3 and R 4 are independently selected from the group consisting of H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl; and

R 5 is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R 5 is null when X is N;

wherein R 2 , R 4 , Y and N or R 2 , R 3 , CH and N do not form a substituted or unsubstituted 4-7 member saturated ring.

2. A compound of Formula (I):

in which:

R 1 is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl;

X is selected from the group consisting of a C and N atom;

Y is selected from the group consisting of CO and SO 2 ;

R 3 is selected from the group consisting of H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl; and

R 5 is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R 5 is null when X is N,

wherein R 2 , R 4 , Y and N form a substituted or unsubstituted 4-7 member saturated ring.

3. A compound of Formula (I):

in which:

R 1 is selected from the group consisting of a substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl and substituted or unsubstituted heteroaryl;

X is selected from the group consisting of a C and N atom;

Y is selected from the group consisting of CO and SO 2 ;

R 4 is selected from the group consisting of H, OH, substituted or unsubstituted aryl, substituted or unsubstituted arylalkyl, substituted or unsubstituted linear, cyclic or branched alkyl, cyano, and perfluoroalkyl; and

R 5 is selected from the group consisting of H, halogen, alkyl, cyano and null, wherein R 5 is null when X is N,

wherein R 2 , R 3 , CH and N form a substituted or unsubstituted 4-7 member saturated ring.

4. The compound of claim 1 , wherein R 1 is a substituted or unsubstituted phenyl or thiophene group.

5. The compound of claim 4 , wherein R 1 is a phenyl group having one or more substituents selected from the group consisting of halogen, cyano, (C 1-6 )alkyl, mono to perfluoro(C 1-3 )alkyl, (C 3-7 )cycloalkyl, (C 2-6 )alkenyl, (C 1-6 )alkoxy, (C 2-6 )alkenoxy, hydroxy, amino, mono- or di-(C 1-6 )alkylamino, acylamino, nitro, carboxy, (C 1-6 )alkoxycarbonyl, (C 1-6 )alkenyloxycarbonyl, (C 1-6 )alkoxycarbonyl(C 1-6 )alkyl, carboxy(C 1-6 )alkyl, (C 1-6 )alkylcarbonyloxy, carboxy(C 1-6 )alkyloxy, (C 1-6 )alkoxycarbonyl(C 1-6 )alkoxy, (C 1-6 )alkylthio, (C 1-6 )alkylsulphinyl, (C 1-6 )alkylsulphonyl, sulphamoyl, mono- and di-(C 1-6 )-alkylsulphamoyl, and carbamoyl.

6. The compound of claim 1 , wherein R 1 is selected from the group consisting of 3-fluorophenyl, 4-fluorophenyl, 3-chlorophenyl, 4-chlorophenyl, 3-bromophenyl, 4-bromophenyl, 3-iodophenyl, 4-iodophenyl, 3-methoxyphenyl, 4-methoxyphenyl, 3-methylphenyl, 4-methylphenyl, 3-trifluoromethylphenyl, 4-trifluoromethylphenyl, 3-4-methylendioxyphenyl, 3-4-difluorophenyl, 3-4-dichlorophenyl, 3-4-dibromophenyl, 3-4-dimethylphenyl, 3-4-(—CH 2 CH 2 CH 2 —)phenyl, 3-4-(—OCH 2 CH 2 O—)phenyl, 3-chloro-4-fluorophenyl, benzo[1,3]dioxyl-5-yl, and 3-3-cyanophenyl, 3,5-difluorophenyl, thiophen-2-yl, thiophen-3-yl, 4,5-di-bromo-thiophen-2yl, 5-chloro-thiophen-2yl, and 5-bromo-thiophen-2yl, 5-fluoro-thiophen-2-yl, 5-chloro-thiophen-3-yl, 1,1,-difluoro-benzo[1,3]dioxyl-5-yl, 7-chlorobenzo[1,3]dioxol-5-yl, 3-nitrophenyl, 2,1,3-benzoxadiazol-5-yl, and 4-nitrophenyl.

7. The compound of claim 1 , wherein Y is a CO group.

8. The compound of claim 7 , wherein X is C atom.

9. The compound of claim 7 , wherein X is N atom.

10. The compound of claim 1 , wherein Y is a SO 2 group.

11. The compound of claim 10 , wherein X is a C atom.

12. The compound of claim 10 , wherein X is an N atom.

13. The compound of claim 1 , wherein R 2 is selected from the group consisting of H, methyl, ethyl, 2-hydroxyethyl, 2-methoxyethyl, 2-aminoethyl, propyl, cyclopropyl, isopropyl, 2,4-dimethoxybenzyl, 2-methanesulfonylaminoethyl, 2,2-Difluoro-ethyl, and 3,5-dimethylisoxazole-4-yl-methyl.

14. The compound of claim 1 , wherein R 3 is selected from the group consisting of H, methyl, ethyl, 2-hydroxyethyl, 2-hydroxymethyl, 2-methoxyethyl, 2-aminoethyl, propyl, cyclopropyl, isopropyl, 2,4-dimethoxybenzyl, and 2-methanesulfonylaminoethyl.

15. The compound of claim 1 , wherein R 4 is selected from the group consisting of methyl, 2-(2-methoxyethoxy)-methyl, 2-methoxymethyl, 4-methylisoxazole-5-yl, isoxazole-5-yl, 3-phenylpropanyl, furan-2-yl, 4-phenoxybutanyl, 1,1-dioxo-tetrahydro-1-lamda6-thiophen-3-ylmethylaminoyl, 3,5-dimethylisoxazole-4-yl, 1-methyl-1H-imidazole-5-yl, furan-3-yl, 3-methylfuran-2-yl, 5-methyl-3-phenylisoxazole-4-yl, 5-methyl-2-phenyl-2H-1,2,3-triazole-4-yl, 5-methylisoxazole-3-yl, 3-methyl-5-phenylisoxazole-4-yl, 3-methyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-yl, 2-(2H-tetrazol-5-yl)methyl, benzofuran-2-yl, 1,2,5-oxadiazole-3-yl, (3,5-dimethylisoxazol-4-yl)-methyl, 3-methylisoxazole-4-yl, 5-methylisoxazole-4-yl, 5-cyclopropyl-isoxazole-4-yl, 2,6-dimethylphenyl, 5-(furan-2-yl)-isoxazole-3-yl, 2,5-dimethyloxazole-4-yl, 2-phenylthiazole-4-yl, 2-(thiophen-2-yl)thiazole-4-yl, 3-hydroxy-isoxazole-5-yl, 5-phenyl-1,3,4-oxadiazole-2-yl, 5-methylfuran-2-yl, 4-methyl-1,2,5-oxadiazole-3-yl, 4-methyl-2-(pyrazin-2-yl)thiazole-5-yl, 2,4-dimethoxy-phenyl, 4-methoxy-phenyl, 3,4-dimethoxy-phenyl, benzo[1,3]dioxole-5-yl, 3,4,5-trimethoxy-phenyl, 5-methyl-3-(trifluoromethyl)isoxazole-4-yl, pyridin-3-ylmethyl, 2,4-dimethylpyridine-3-yl, 2,4,6-trimethylphenyl, 5-(methoxymethyl)-3-methylisoxazole-4-yl, 2-methoxy-methyl, 2-methoxyformyl, 3-ethyl-5-methylisoxazole-4-yl, pyrimidine-5-yl, pyrazine-2-yl, 5-methylpyrazine-2-yl, furan-3-yl, 4-methyloxazole-5-yl, 2-tosylmethyl, 3-ethylcarboxy-5-methylisoxazole-4-yl, 3-carboxy-5-methylisoxazole-4-yl, 2-methylpyridine-3-yl, 4-methylpyridine-3-yl, 3-chloro-4-(methylsulfonyl)thiophene-2-yl, 4-methylthiazole-5-yl, 5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-yl, 4-methyl-2-(methylthio)pyrimidine-5-yl, 2-methylprop-1-enyl, 2-methylphenyl, quinoxaline-2,3-methylpyridine-4-yl, 3-methylisoxazole-4-yl, 4-amino-pyrimidine-5-yl, 2-amino-4-methylpyrimidine-5-yl, 4,6-dimethyl-2-oxo-1,2-dihydropyridine-3-yl, 2,4,6-trimethylpyrimidine-5-yl, 3-methylpyrazine-2-yl, 4-Boc-amino-1-methyl-1H-imidazole-2-yl, 4-amino-1-methyl-1H-imidazole-2-yl, 4-acetamido-1-methyl-1H-imidazole-2-yl, 4,6-dimethylpyrimidine-5-yl, 3-(hydroxymethyl)-5-methylisoxazole-4-yl, 3-methylpyridine-2-yl, 2-amino-4,6-dimethylpyrimidine-5-yl, 2-methylimidazo[1,2-a]pyridine-3-yl, tetrahydrofuran-2-yl, 2-methoxypyridine-3-yl, tetrahydrofuran-3-yl, methoxyformyl, 2-chloropyridine-3-yl, 1,3,5-tetramethyl-1H-pyrazole-4-yl, (S)-tetrahydrofuran-2-yl, (R)-tetrahydrofuran-2-yl, 3-propoxypyridine-4-yl, N-Boc-morpholine-2-yl, morpholine-2-yl, pyridazine-4-yl, 3,5-dimethyl-1H-pyrazole-4-yl, pyridazine-3-yl, tetrahydro-2H-pyran-4-yl, 1,5-dimethyl-1H-pyrazole-4-yl, morpholine-3-yl, 4-methylpyrrolidine-3-yl, (S)-pyrrolidine-2-yl, 1,1-Dioxo-tetrahydro-1-lamda6-thiophene-3-yl, 4-methylphenyl, methyl, ethyl, propyl, butyl, cyclopropyl, and 1,1-Dioxo-1-isothiazolidin-2-yl, 2-methyl-5,6-dihydro-4H-pyran-3-yl, 2-methyl-5-morpholin-4-ylmethyl-furan-3-yl, 2-methyl-but-2-enyl, [1,2,3]thiadiazole-4-yl, 2-pyridin-3-yl-thiazole-4-yl, 2,5-dimethyl-2H-pyrazole-3-yl, 4-methyl-furazan-3-yl, 2-morpholin-4-ylmethyl-furan-3-yl, 1-methyl-pyrrolidine-2-yl, 1-methyl-1H-pyrrole-2-yl, 1,5-dimethyl-1H-[1,2,3]triazole-4-yl, 5-fluoro-thiophene-2-yl, 4-methyl-pyrimidine-5-yl, 4-methyl-2-phenyl-pyrimidine-5-yl, 2-methylsulfanyl-nicotinyl, acetonitrile, 6-morpholin-4-yl-nicotinyl, 4-methyl-thiazole-5-yl, 3-methyl-1H-pyrazole-4-yl, 2,4-dimethyl-pyrimidine-5-yl, 2-methyl-[1,6]naphthyridine-3-yl, 6-(4-methoxy-phenyl)-pyridazine-3-yl, 2,6-bis-dimethylamino-pyrimidine-4-yl, 2,6-di-morpholin-4-yl-pyrimidine-4-yl, 3-pyridin-3-yl-acrylonitrile-2-yl, 2-methyl-[1,8]naphthyridine-3-yl, 2-dimethylamino-6-methyl-pyrimidine-4-yl, acetic acid 1-yl-ethyl ester, 1-ethyl-3-methyl-1H-pyrazole-4-yl, 2-methyl-pyrazolo[1,5-a]pyrimidine-3-yl, 1-hydroxy-ethyl, 1-ethyl-5-methyl-1H-pyrazole-4-yl, 5,7-dimethyl-pyrazolo[1,5-a]pyrimidine-3-yl, 1-methyl-1H-indole-3-yl, 1-methyl-1H-indazole-3-yl, pyrazolo[1,5-a]pyridine-3-yl, 2-furan-2-yl-oxo, 5-oxo-pyrrolidine-2-yl, 4-methyl-pyridazine-3-yl, 5-methyl-pyridazine-4-yl, 3-amino-1H-pyrazole-4-yl, 3,6-dimethoxy-pyridazine-4-yl, 3,6-dichloro-pyridazine-4-yl, pyridine-3-yl, pyridine-2-yl, 1-methyl-1H-imidazole-4-yl, 1,2-dimethyl-1H-imidazole-4-yl, pyridin-3-yl-methyl, 3-chloro-6-methoxy-pyridazin-4-yl, 3,5-dimethyl-pyridazin-4-yl, 1-methyl-3-trifluoromethyl-1H-pyrazol-4-yl, 3-chloro-6-hydroxy-pyridazin-4-yl, 2-methyl-tetrahydrofuran-2-yl, 4-chloro-1-methyl-1H-pyrazol-3-yl, 5-chloro-1-methyl-1H-pyrazol-4-yl, 4-chloro-2-methyl-2H-pyrazol-3-yl, 4-chloro-1H-pyrazol-3-yl, 1,3,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-3-yl, 2-methyl-5-sulfamoyl-phenyl, 1-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl, 1-phenyl-cyclobutyl, 3-methyl-4-oxo-3,4-dihydrophthalazin-1-yl, 7-chloro-benzo[1,3]dioxol-5-yl, 6-[1,2,4]triazol-1-yl-pyridin-3-yl, 1-(2-methoxyethyl)-6-oxo-1,6-dihydropyridazin-3-yl, 2-(2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)methyl, 6-chloro-3-hydroxy-pyridazin-4-yl, 3-cyano-2-hydroxy-6-methyl-pyridin-4-yl, 1-methyl-5-(1H-pyrrol-1-yl)-1H-pyrazol-4-yl, 4-oxo-3,4-dihydrophthalazin-1-yl, 4,6-dimethyl-2-oxo-2H-pyran-5-yl, 1-methyl-4-sulfamoyl-1H-pyrrol-2-yl, (5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)methyl, 3,6-dimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidin-5-yl, 5-methyl-4-oxo-3,4-dihydrothieno[2,3-b]pyrimidin-6-yl, phenyl-difluoromethyl, 4-hydroxyl-1-carbamoyl-pyrrolidin-2-yl, 2-(1-morpholino)-pyridin-3-yl, 1-(3-fluorophenyl)-cyclobutyl, 1-methyl-5-trifluoromethyl-1H-pyrazol-4-yl, (S)-1-methoxyethyl, 3-methyl-5,6-dihydro-1,4-dioxin-2-yl, (R)-5-oxo-tetrahydrofuran-2-yl, 5-chloro-1,3-dimethyl-1H-pyraozol-4-yl, 2-methoxy-ethyl, 1-(2-hydroxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl, (R)-1-methoxy-ethyl, 1-(2-methoxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl, tetrahydro-2H-pyran-2-yl, 3,6-dimethylisoxazolo[5,4-b]pyridine-4-yl, 5-methoxy-tetrahydrofuran-2-yl, 1-(4-methoxybutyl)-3,5-dimethyl-1H-pyrazol-4-yl, 1-(3-methoxypropyl)-3,5-dimethyl-1H-pyrazol-4-yl, 1-(4-fluorophenyl)-cyclobutyl, 5-methyl-tetrahydrofuran-2-yl, 3-methyl-oxetan-3-yl, 5-chloro-1H-pyrazol-4-yl, (R)-2,2-dimethyl-1,3-dioxolan-4-yl, (S)-2,2-dimethyl-1,3-dioxolan-4-yl, 3,6-dichloro-5-methyl-pyridazin-4-yl, 6-methoxyl-3-methyl-pyridazin-4-yl, 1-methyl-5-nitro-1H pyrazol-4-yl, 2,3-dihydrobenzofuran-2-yl, 6-hydroxy-3-methyl-pyridazin-4-yl, 2-(1-pyrrolidinyl)-pyridin-3-yl, 3-oxo-3-(2-thiophenyl)-propyl, 3-oxo-3-phenyl-propyl, 3-fluoro-4-methoxy-benzyl, 3,4-dimethoxy-benzyl, 4-(hydroxymethyl)-phenoxy-methyl, 3-methylsulfonyl-benzyl, 2-mercapto-4-methyl-thiazol-5-yl, 5-trifluoromethyl-furan-2-yl, 6-hydroxy-3-methylamino-pyridazin-4-yl, 3-(dimethylamino)-6-methoxy-pyridazin-4-yl, 2,2-dimethyl-tetrahydro-2H-pyran-4-yl, 4-(dimethylamino)-benzyl, 7-hydroxy-1,2,3,4-tetrahydroisoquinolin-3-yl, 1H-benzoimidazol-2-yl, naphthalene-2-yl-methyl, 4-methoxy-3-methyl-benzyl, 1-amino-2-benzyloxy-ethyl, 1,4-dioxo-1,2,3,4-tetrahydrophthalazin-6-yl, 2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-methyl, 5-nitro-1H-pyrazol-4-yl, (S)-3,3-difluoro-tetrahydrofuran-2-yl, chroman-2-yl, 3,5-dimethyl-1H-pyrazol-4-yl, 4-butynyl, 2-methyl-1,2,34-tetrahydroisoquinolin-3-yl, (S)-2-(4-pyridinyl), 1-amino-ethyl, cis-3-methoxy-tetrahydrofuran-2-yl, 1-cyano-cyclopropyl, ethynyl, 1-ethoxy-ethyl, 1-(4-methoxy-phenoxy)ethyl, 1-(cyclopropylmethoxy)ethyl, 1,4-diamino-butyl, 1-(2-phenoxyethoxy)ethyl, cyclopropylmethyl, 3-ethyl-3-oxetan-3-yl, 1-(2,2-difluoroethoxy)ethyl, 1-(4-fluoro-benzyloxy)ethyl, 1-(2,2,2-trifluoroethoxy)ethyl, 1-(prop-2-ynyloxy)ethyl, 5-methyl-isoxazol-3-yl, 1-((1-methyl-pyrrolidin-3-yl)oxy)ethyl, 1-(2-hydroxyethoxy)ethyl, cyclopentyl, 1-hydroxy-cyclopropyl, cyclohexyl, 2-methyl cyclohexyl, 2-oxo-2,3-dihydrobenzoxazol-6-yl, 2,2,2-trifluoroethyl, 1-hydroxy-1-methyl-ethyl, (R)-5-(hydroxymethyl)tetrahydrofuran-2-yl, (4-hydroxy-2-oxo-pyrrolidin-1-yl)methyl, 1,2,2,2-tetrafluoroethyl, 1-carbamoyl-cyclopropyl, 2-methyl-cyclopropyl, 5-chloro-1,3-dimethyl-1H-pyrazol-4-yl, 5-isopropyl-3-methyl-isoxazol-4-yl, and 1,3,5-trimethyl-1H-pyrazolo[4,3-b]pyridin-7-yl.

16. The compound of claim 2 , wherein R 2 , R 4 , Y and N together form 2,4-dioxothiazolidin-3-yl.

17. The compound of claim 2 , wherein R 2 , R 4 , Y and N together form 2-oxooxazolidin-3-yl.

18. The compound of claim 3 , wherein R 2 , R 3 , CH and N together form 4-aceoxy-1-(methylsulfonyl)pyrrolidin-2-yl.

19. The compound of claim 3 , wherein R 2 , R 3 , CH and N together form 4-hydroxy-1-(methylsulfonyl)pyrrolidin-2-yl.

20. A compound selected from the group consisting of:

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-methoxyethyl)acetamide;

3-(N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)acetamido)propylphosphonic acid;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-methoxyethoxy)-N-methylacetamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylacetamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylisoxazole-5-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylisoxazole-5-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-phenylpropanamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-2-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-phenoxybutanamide;

1-(3,4-Dichloro-benzyl)-3-{4-[3-(1,1-dioxo-tetrahydro-1,6-thiophen-3-ylmethyl)-1-methyl-ureidomethyl]-thiazol-2-yl}-urea;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-5-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-3-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylfuran-2-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-3-phenylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-ethyl-3,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-isopropyl-3,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-2-phenyl-2H-1,2,3-triazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-3-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5-phenylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5-(4-methyl-1,2,3-thiadiazol-5-yl)isoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(2H-tetrazol-5-yl)acetamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzofuran-2-carboxamide;

N-(1-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)ethyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,2,5-oxadiazole-3-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2-(3,5-dimethylisoxazol-4-yl)-N-methylacetamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3-ethyl-N,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide;

5-cyclopropyl-N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,6-trimethylbenzamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-5-(furan-2-yl)-N-methylisoxazole-3-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,5-trimethyloxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-phenylthiazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2,4-dimethoxybenzyl)-3,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-methoxyethyl)-3,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(thiophen-2-yl)thiazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylisoxazole-5-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-phenyl-1,3,4-oxadiazole-2-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylfuran-2-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyl-1,2,5-oxadiazole-3-carboxamide;

4-Methyl-2-pyrazin-2-yl-thiazole-5-carboxylic acid {2-[3-(3,4-dichlorobenzyl)ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-2,4-dimethoxy-N-methylbenzamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-4-methoxy-N-methylbenzamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3,4-dimethoxy-N-methylbenzamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzo[1,3]dioxole-5-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-3,4,5-trimethoxy-N-methylbenzamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-3-(trifluoromethyl)isoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyridin-3-yl)acetamide;

N-(1-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-2-(methylamino)-2-oxoethyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4-trimethylnicotinamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4,6-tetramethylbenzamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-hydroxyethyl)-3,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-(methoxymethyl)-N,3-dimethylisoxazole-4-carb oxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-5-(methoxymethyl)-N,3-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylacetamide;

methyl 2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)amino)-2-oxoacetate;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisoxazole-4-carboxamide;

3-ethyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4-trimethylnicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrazine-2-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrazine-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylpyrazine-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylfuran-3-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyloxazole-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-3-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-tosylacetamide;

Ethyl 4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylate;

4-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-5-methylisoxazole-3-carboxylic acid;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylnicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylnicotinamide;

3-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-(methylsulfonyl)thiophene-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylthiazole-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-oxo-3,5-dihydro-2H-thiazolo[3,2-a]pyrimidine-6-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethyl-2-(methylthio)pyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylbut-2-enamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylbenzamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylquinoxaline-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpicolinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-((4-methoxybenzyloxy)methyl)-N,3-dimethylisoxazole-4-carboxamide;

N-(2-Aminoethyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3,5-dimethylisoxazole-4-carboxamide;

4-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrimidine-5-carboxamide;

2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylpyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3,5-dimethyl-N-(2-(methylsulfonamido)ethyl)isoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-1,2-dihydropyridine-3-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,4,6-tetramethylpyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide;

tert-butyl 2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)-1-methyl-1H-imidazol-4-ylcarbamate;

4-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-2-carboxamide;

4-acetamido-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-1H-imidazole-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethylpyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-(hydroxymethyl)-N,5-dimethylisoxazole-4-carboxamide;

N-((2-(3-(4-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisonicotinamide;

N-((2-(3-(3-chlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(benzo[1,3]dioxol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethylpyrimidine-5-carboxamide;

N-((2-(3-((2,2-difluorobenzo[1,3]dioxol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylimidazo[1,2-a]pyridine-3-carboxamide;

N,3,5-trimethyl-N-((2-(3-(3-(N-methylacetamido)benzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

1-(4-((2,4-dioxothiazolidin-3-yl)methyl)thiazol-2-yl)-3-(3-fluorobenzyl)urea;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylnicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-3-carboxamide;

N,3,5-trimethyl-N-((2-(3-(thiophen-3-ylmethyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide;

methyl (2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl(2-hydroxyethyl)carbamate;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-hydroxyethyl)-3-methylisonicotinamide;

1-(3-fluorobenzyl)-3-(4-((2-oxooxazolidin-3-yl)methyl)thiazol-2-yl)urea;

2-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylnicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3,5-tetramethyl-1H-pyrazole-4-carboxamide;

(S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

(R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-propoxypicolinamide;

tert-butyl 2-(((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)(methyl)carbamoyl)morpholine-4-carboxylate;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmorpholine-2-carboxamide;

N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide;

N-((2-(3-(3,5-difluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylisonicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyridazine-3-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydro-2H-pyran-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,5-trimethyl-1H-pyrazole-4-carboxamide;

N-((2-(3-((5-chlorofuran-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmorpholine-3-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylpyrrolidine-3-carboxamide;

(S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpyrrolidine-2-carboxamide;

2-Methyl-5,6-dihydro-4H-pyran-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Methyl-5-morpholin-4-ylmethyl-furan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Methyl-but-2-enoic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,2,3-Thiadiazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid {2-[3-(5-fluoro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Pyridin-3-yl-thiazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2,5-Dimethyl-2H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

4-Methyl-furazan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Morpholin-4-ylmethyl-furan-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1-Methyl-pyrrolidine-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1-Methyl-1H-pyrrole-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,5-Dimethyl-1H-[1,2,3]triazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

5-Fluoro-thiophene-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

4-Methyl-pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

4-Methyl-2-phenyl-pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-2-methylsulfanyl-nicotinamide;

2-Cyano-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-acetamide;

3,5-Dimethyl-isoxazole-4-carboxylic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-6-morpholin-4-yl-nicotinamide;

4-Methyl-thiazole-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2,4-Dimethyl-pyrimidine-5-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Methyl-[1,6]naphthyridine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

6-(4-Methoxy-phenyl)-pyridazine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Methyl-pyrazine-2-carboxylic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Methyl-pyrazine-2-carboxylic acid {5-chloro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2,6-Bis-dimethylamino-pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2,6-Di-morpholin-4-yl-pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Cyano-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-3-pyridin-3-yl-acrylamide;

2-Methyl-[1,8]naphthyridine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Dimethylamino-6-methyl-pyrimidine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-methoxy-N-methyl-2-phenyl-acetamide;

3-Methyl-pyrazine-2-carboxylic acid {2-[3-(5-fluoro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Methyl-pyrazine-2-carboxylic acid methyl-[2-(3-thiophen-3-ylmethyl-ureido)-thiazol-4-ylmethyl]-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid {5-cyano-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

Acetic acid 1-({2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-carbamoyl)-ethyl ester;

1-Ethyl-3-methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Methyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-hydroxy-N-methyl-propionamide;

3,5-Dimethyl-isoxazole-4-carboxylic acid (1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-ethyl)-amide;

1-Ethyl-5-methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

5,7-Dimethyl-pyrazolo[1,5-a]pyrimidine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid (1-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-2-hydroxy-ethyl)-amide;

1-Methyl-1H-indole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1-Methyl-1H-indazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

Pyrazolo[1,5-a]pyridine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-2-furan-2-yl-N-methyl-2-oxo-acetamide;

3,5-Dimethyl-isoxazole-4-carboxylic acid [2-(3-benzyl-ureido)-thiazol-4-ylmethyl]-methyl-amide;

3-Methyl-pyrazine-2-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-5-isopropyl-thiazol-4-ylmethyl}-methyl-amide;

5-Oxo-pyrrolidine-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Methyl-pyrazine-2-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid (2,2-difluoro-ethyl)-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-amide;

4-Methyl-pyridazine-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

5-Methyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Amino-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,6-Dimethoxy-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

(3,5-Dimethyl-isoxazol-4-ylmethyl)-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-carbamic acid methyl ester;

(R)-Tetrahydro-furan-2-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

5-Methyl-pyridazine-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

5-Methyl-pyridazine-4-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

Tetrahydro-furan-2-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-3-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,6-Dichloro-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Chloro-6-methoxy-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

(R)-Tetrahydro-furan-2-carboxylic acid {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{5-Fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-acetamide;

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {5-fluoro-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Chloro-6-hydroxy-pyridazine-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

2-Methyl-tetrahydro-furan-2-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

4-Chloro-1-methyl-1H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

5-Chloro-1-methyl-1H-pyrazole-4-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

4-Chloro-2-methyl-2H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

4-Chloro-1H-pyrazole-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3,5-Dimethyl-isoxazole-4-carboxylic acid (cyano-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-yl}-methyl)-methyl-amide;

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,3,6-Trimethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide;

1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1-Phenyl-cyclobutanecarboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

7-Chloro-benzo[1,3]dioxole-5-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide;

1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid {2-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-methylacetamide;

1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid {2-[3-(5-chlorothiophen-2-yl)methyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-hydroxy-N-methylpyridazine-4-carboxamide;

5-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3-trimethyl-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-isopropyl-N,3-dimethylisoxazole-4-carboxamide;

3-cyano-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,6-dimethylisonicotinamide;

6-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-oxo-2,3-dihydropyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethyl-5-sulfamoylbenzamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1-phenylcyclobutanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-2H-pyran-5-carboxamide;

7-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzo[1,3]dioxole-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-4-sulfamoyl-1H-pyrrole-2-carboxamide;

2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide;

2,2-difluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-phenylacetamide;

N2-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-4-hydroxy-N2-methylpyrrolidine-1,2-dicarboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-morpholinonicotinamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,4,6-trimethyl-2-oxo-2H-pyran-5-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-4-sulfamoyl-1H-pyrrole-2-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-methylacetamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidine-6-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-1-(3-fluorophenyl)-N-methylcyclobutanecarboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2,2-difluoro-N-methyl-2-phenylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxamide;

(S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-5,6-dihydro-1,4-dioxine-2-carboxamide;

(R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-oxotetrahydrofuran-2-carboxamide;

5-chloro-N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1,3-trimethyl-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-6-oxo-1,4,5,6-tetrahydropyridazine-3-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyl-4-oxo-3,4-dihydrophthalazine-1-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-4-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethyl-4-oxo-3,4-dihydrofuro[2,3-d]pyrimidine-5-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-hydroxyethyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide;

(R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-methoxyethyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydro-2H-pyran-2-carboxamide;

N-(cyano(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide;

N-(cyano(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethylisoxazolo[5,4-b]pyridine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-methoxy-N-methyltetrahydrofuran-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(4-methoxybutyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(3-methoxypropyl)-N,3,5-trimethyl-1H-pyrazole-4-carboxamide;

N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylpyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-morpholinonicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,6-trimethylisoxazolo[5,4-b]pyridine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(4-fluorophenyl)-N-methylcyclobutanecarboxamide;

1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethyltetrahydrofuran-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyloxetane-3-carboxamide;

5-chloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1H-pyrazole-4-carboxamide;

(R)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyl-1,3-dioxolane-4-carboxamide;

(S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyl-1,3-dioxolane-4-carboxamide;

N-(2-amino-1-(2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)ethyl)-N-methyltetrahydrofuran-2-carboxamide;

(R)—N-((2-(3-((5-fluorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

3,6-dichloro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,5-dimethylpyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N,3-dimethylpyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1,3,6-tetramethyl-1H-pyrazolo[3,4-b]pyridine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-nitro-1H-pyrazole-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2,3-dihydrobenzofuran-2-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2,3-dihydrobenzofuran-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N,3-dimethylpyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyrrolidin-1-yl)nicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-4-(thiophen-2-yl)butanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-4-oxo-4-phenylbutanamide;

2-(3-fluoro-4-methoxyphenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

2-(3,4-dimethoxyphenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-(hydroxymethyl)phenoxy)-N-methylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(3-(methylsulfonyl)phenyl)acetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-mercapto-4-methylthiazol-5-yl)-N-methylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-5-(trifluoromethyl)furan-2-carboxamide;

(R)—N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-methoxy-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-hydroxy-N-methyl-3-(methylamino)pyridazine-4-carboxamide;

3-(dimethylamino)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-6-methoxy-N-methylpyridazine-4-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-1-(2-methoxyethyl)-N-methyl-6-oxo-1,6-dihydropyridazine-3-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(pyrrolidin-1-yl)nicotinamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyltetrahydro-2H-pyran-4-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,2,2-trimethyltetrahydro-2H-pyran-4-carboxamide;

N-((2-(3-((1H-indol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(benzo[1,2,5]oxadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(benzo[1,2,5]thiadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

2-(4-(dimethylamino)phenyl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-7-hydroxy-N-methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;

3-(1H-benzoimidazol-2-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(naphthalen-2-yl)acetamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-methoxy-3-methylphenyl)-N-methylacetamide;

2-amino-3-(benzyloxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-6-(1H-1,2,4-triazol-1-yl)nicotinamide;

2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-1,4-dioxo-1,2,3,4-tetrahydrophthalazine-6-carboxamide;

N2-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-4-hydroxy-N2-methylpyrrolidine-1,2-dicarboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,1-dimethyl-5-nitro-1H-pyrazole-4-carboxamide;

(S)-3,3-difluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylchroman-2-carboxamide;

4-(3,5-dimethyl-1H-pyrazol-4-yl)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbenzamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpent-4-ynamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide;

(S)-2-amino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-3-(pyridin-4-yl)propanamide;

cis-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-3-methoxy-N-methyltetrahydrofuran-2-carboxamide;

1-cyano-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropiolamide;

N-((2-(3-((1H-indol-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((2-(3-(benzoxazol-6-ylmethyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

2-ethoxy-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-methoxyphenoxy)-N-methylpropanamide;

2-(cyclopropylmethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

2,5-diamino-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpentanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(2-phenoxyethoxy)propanamide;

2-cyclopropyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylacetamide;

N,3,5-trimethyl-N-((2-(3-(4-nitrobenzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide;

N,3,5-trimethyl-N-((2-(3-(3-nitrobenzyl)ureido)thiazol-4-yl)methyl)isoxazole-4-carboxamide;

3-ethyl-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyloxetane-3-carboxamide;

2-(2,2-difluoroethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-fluorobenzyloxy)propanamide;

2-(2,2,2-trifluoroethoxy)-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(prop-2-ynyloxy)propanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-((5-methylisoxazol-3-yl)methoxy)propanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-(1-methylpyrrolidin-3-yloxy)propanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(2-hydroxyethoxy)propanamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopentanecarboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-1-hydroxy-N-methylcyclopropanecarboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methylcyclohexanecarboxamide;

1-cyano-N-((5-fluoro-2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopentanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylcyclohexanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclohexanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-oxo-2,3-dihydrobenzoxazole-6-carboxamide;

3,3,3-trifluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,2-dimethylpropanamide;

2,3-cis-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3-dimethyltetrahydrofuran-2-carboxamide;

(5R)-—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-5-(hydroxymethyl)-N-methyltetrahydrofuran-2-carboxamide;

N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-hydroxy-N,2-dimethylpropanamide;

N-((2-(3-(5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyl-2-oxo-2,3-dihydrobenzoxazole-6-carboxamide;

(S)—N-((2-(3-((5-chlorothiophen-2-yl)methyl)ureido)thiazol-4-yl)methyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)-N-methylacetamide;

(R)—N-((2-(3-(benzo[1,2,5]oxadiazol-5-ylmethyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

(R)—N-((2-(3-((7-chlorobenzo[1,3]dioxol-5-yl)methyl)ureido)thiazol-4-yl)methyl)-N-methyltetrahydrofuran-2-carboxamide;

2,3,3,3-tetrafluoro-N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropanamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanecarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropane-1,1-dicarboxamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,2-dimethylcyclopropanecarboxamide;

(S)—N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-2-(4-hydroxy-2-oxopyrrolidin-1-yl)-N-methylacetamide;

N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3,5-trimethylisoxazole-4-carboxamide;

N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,2,6-trimethylbenzamide;

N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3-dimethylisonicotinamide;

N-((5-(3-(3-fluorobenzyl)ureido)-1,2,4-thiadiazol-3-yl)methyl)-N,3-dimethylpyrazine-2-carboxamide;

1,3,5-Trimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

5-Isopropyl-3-methyl-isoxazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1,3,5-Trimethyl-1H-pyrazolo[4,3-b]pyridine-7-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-5-pyrrol-1-yl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

3,6-Dimethyl-isoxazolo[5,4-b]pyridine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2-(5,7-Dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-acetamide;

3,6-Dimethyl-4-oxo-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide;

1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-4-sulfamoyl-1H-pyrrole-2-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-(5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)-N-methyl-acetamide;

3,6-Dimethyl-4-oxo-3,4-dihydro-furo[2,3-d]pyrimidine-5-carboxylic acid{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

(R)-Tetrahydro-furan-2-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1,3,5-Trimethyl-1H-pyrazolo[4,3-b]pyridine-7-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-3-cyano-2-hydroxy-6,N-dimethyl-isonicotinamide;

6-Chloro-3-oxo-2,3-dihydro-pyridazine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

7-Chloro-benzo[1,3]dioxole-5-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

5-Methyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-5-pyrrol-1-yl-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-6-oxo-1,4,5,6-tetrahydro-pyridazine-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

3-Methyl-4-oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,4-Dimethyl-6-oxo-6H-pyran-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

5-Methyl-4-oxo-3,4-dihydro-thieno[2,3-d]pyrimidine-6-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-6-[1,2,4]triazol-1-yl-nicotinamide;

1-(2-Methoxy-ethyl)-6-oxo-1,6-dihydro-pyridazine-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,2-difluoro-N-methyl-2-phenyl-acetamide;

(R)-Tetrahydro-furan-2-carboxylic acid [5-(3-benzo[1,2,5]oxadiazol-5-ylmethyl-ureido)-[1,2,4]thiadiazol-3-ylmethyl]-methyl-amide;

3,5-Dimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

3,5-Dimethyl-pyridazine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

5-Isopropyl-3-methyl-isoxazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide;

1,1-Dioxo-tetrahydrothiophene-3-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-morpholin-4-yl-nicotinamide;

1-Phenyl-cyclobutanecarboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

4-Oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

7-Chloro-benzo[1,3]dioxole-5-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-(4-Fluoro-phenyl)-cyclobutanecarboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-3-trifluoromethyl-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

5-Chloro-1,3-dimethyl-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Phenyl-cyclobutanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

4-Oxo-3,4-dihydro-phthalazine-1-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-(4-Fluoro-phenyl)-cyclobutanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,2-Difluoro-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-phenyl-acetamide;

1,1-Dioxo-tetrahydro-llambda*6*-thiophene-3-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,2-Dimethyl-tetrahydro-pyran-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,3-Dihydro-benzofuran-2-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

(R)-Tetrahydro-furan-2-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,2-Dimethyl-tetrahydro-pyran-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Methyl-5-nitro-1H-pyrazole-4-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,3-Dihydro-benzofuran-2-carboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

(R)—N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-methoxy-N-methyl-propionamide;

(R)—N-{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-methoxy-N-methyl-propionamide;

N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-morpholin-4-yl-nicotinamide;

N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyrrolidin-1-yl-nicotinamide;

N-{5-[3-(5-Chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2,N-dimethyl-5-sulfamoyl-benzamide;

N-{5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyrrolidin-1-yl-nicotinamide;

2,2-Difluoro-N-{5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-N-methyl-2-pyridin-2-yl-acetamide;

1-Methyl-4-sulfamoyl-1H-pyrrole-2-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

4-Hydroxy-pyrrolidine-1,2-dicarboxylic acid 1-amide 2-({5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide);

Cyclopentanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2-Methyl-cyclohexanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

Cyclohexanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2,6-Dioxo-hexahydro-pyrimidine-4-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Cyano-cyclopropanecarboxylic acid {5-[3-(5-chloro-thiophen-2-ylmethyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

1-Hydroxy-cyclopropanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

2-Oxo-2,3-dihydro-benzooxazole-6-carboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-hydroxy-2,N-dimethyl-propionamide;

1-Cyano-cyclopropanecarboxylic acid {5-[3-(3-fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-methyl-amide;

N-{5-[3-(3-Fluoro-benzyl)-ureido]-[1,2,4]thiadiazol-3-ylmethyl}-2-((S)-4-hydroxy-2-oxo-pyrrolidin-1-yl)-N-methyl-acetamide;

1,1-Dioxo-tetrahydro-116-thiophene-3-sulfonic acid {2-[3-(3,4-dichloro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,4-dimethylbenzenesulfonamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-sulfonamide;

N-((2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmethanesulfonamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylmethanesulfonamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylpropane-1-sulfonamide;

1-(3,4-dichlorobenzyl)-3-(4-(4-hydroxy-1-(methylsulfonyl)pyrrolidin-2-yl)thiazol-2-yl)urea;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylbutane-1-sulfonamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylethanesulfonamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N,3,5-trimethylisoxazole-4-sulfonamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-methylcyclopropanesulfonamide;

N-((2-(3-(3-fluorobenzyl)ureido)thiazol-4-yl)methyl)-N-(2-(methylsulfonamido)ethyl)methanesulfonamide;

1-[4-(1,1-Dioxo-116-isothiazolidin-2-ylmethyl)-thiazol-2-yl]-3-(3-fluoro-benzyl)-urea;

Ethanesulfonic acid {5-bromo-2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-4-morpholin-4-yl-benzenesulfonamide;

Furan-2-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

Thiophene-2-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

Pyridine-3-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

Pyridine-2-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1-Methyl-1H-imidazole-4-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

1,2-Dimethyl-1H-imidazole-4-sulfonic acid {2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methyl-amide;

N-{2-[3-(3-Fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-N-methyl-C-pyridin-3-yl-methanesulfonamide;

N-(3,5-Dimethyl-isoxazol-4-ylmethyl)-N-{2-[3-(3-fluoro-benzyl)-ureido]-thiazol-4-ylmethyl}-methanesulfonamide.

21. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt of a compound of claim 1 .

22. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 20 or a pharmaceutically acceptable salt of a compound of claim 20 .

23. The compound of claim 3 , selected from the group consisting of 5-(2-(3-(3,4-dichlorobenzyl)ureido)thiazol-4-yl)-1-(methylsulfonyl)pyrrolidin-3-yl acetate and 1-(3-Fluoro-benzyl)-3-{4-[1-(propane-1-sulfonyl)-pyrrolidin-2-yl]-thiazol-2-yl}-urea.