Phosphodiesterase 4 inhibitors for cognitive and motor rehabilitation

1. A method comprising:

(a) providing cognitive training to an animal having a central nervous system disorder or condition under conditions sufficient to produce an improvement in performance by said animal of a cognitive task whose deficit is associated with said central nervous system (CNS) disorder or condition;

(b) administering in conjunction with said cognitive training a phosphodiesterase 4 (PDE4) inhibitor that enhances CREB pathway function during said cognitive training;

(c) repeating said providing and administering of steps (a) and (b) one or more times; and

(d) reducing the number of training sessions sufficient to produce said improvement in performance relative to the improvement in performance produced by cognitive training alone;

wherein said phosphodiesterase 4 (PDE4) inhibitor is one or more compounds of Formula I:

wherein “Me” means “methyl” and “cPent” means “cyclopentyl” and enantiomers and mixtures thereof.

2. The method of claim 1 wherein said animal is a human.

3. The method of claim 2 wherein said cognitive deficit is mental retardation.

4. The method of claim 2 wherein said cognitive deficit is memory impairment.

5. The method of claim 4 wherein said memory impairment is age-associated.

6. The method of claim 2 wherein said cognitive deficit is associated with a neurodegenerative disease or condition.

7. The method of claim 2 wherein said cognitive deficit is associated with a psychiatric disease or condition.

8. The method of claim 2 wherein said deficit is associated with a trauma dependent loss in cognitive function.

9. The method of claim 2 wherein said cognitive deficit is associated with a genetic defect.

10. The method of claim 2 wherein said cognitive deficit results from neuronal stem cell manipulation.