Cell transplant device for treatment of corneal wound
View Patent ↗A device for transplanting a graft such as a layer or layers of cultivated, autologous, allogenic or xenogenic cells to cover an accidental or surgical wound. The graft is cultivated and carried on a bed of collagen or other dissolvable or releasable material mounted on a protective substrate molded to conform to the profile of the wounded area and provided with a lateral attachment zone. The device facilitates the graft cultured in vitro to the recipient surface.
1. A living cell transplant device for treatment of a surgical or accidental corneal wound, wherein the device comprises:
a) a removable substrate formed in the shape of a contact lens having a central zone and a lateral zone peripheral to the central zone, wherein the central zone comprises a concave posterior face and a convex anterior face, and wherein the substrate further comprises an ophthalmologically acceptable contact lens material;
b) a releasable layer coating the concave posterior face;
c) a plurality of living, transplantable cells upon the releasable layer, wherein the releasable layer is designed to facilitate release of the living, transplantable cells upon the corneal wound to effect transplantation thereof; and
d) means for attaching the lateral zone of the substrate formed in the shape of a contact lens around the wound.
2. The device of claim 1 , wherein the means for attaching the substrate in the form of a contact lens comprises at least one patch of adhesive material applied to the lateral zone.
3. The device of claim 1 , which further comprises means for dissolving the releasable layer.
4. The device of claim 1 , wherein the releasable layer is selected from the group consisting of collagen, amniotic membrane, cellulose, gelatin, and agarose.
5. The device of claim 2 , wherein the adhesive material is selected from the group consisting of fibrin and cyanoacrylate.
6. The device of claim 1 , which further comprises at least one partition projecting from the concave posterior face and dividing the central zone into separate areas.
7. The device of claim 1 , wherein the contact lens is formed in the shape of an ophthalmic conformer.