Heteroaromatic selective inhibitors of neuronal nitric oxide synthase
Compounds selectively inhibiting neuronal nitric oxide synthase (nNos), such compounds of a formula wherein the variables are defined, herein.
1. A method of inhibiting neuronal nitric oxide synthase, said method comprising contacting a neuronal nitric oxide synthase with an effective amount of a compound of a formula
wherein X is CH; m and n are each 1; Y is N; p and q are each 1; Z is NH; R 1 is a substituted alkyl moiety, said R 1 substituents selected from amino, hydroxy and phenyl substituents; and R 2 is a substituted alkyl moiety, said R 2 substituents selected from hydroxy, amino, alkylamino, pyrrolindinyl, alkoxycarbonyl, alkylamido, carbamoyl, pyridinyl, phenylalkyl and phenyl substituents and combinations of said substituents; and salts thereof.
2. The method of claim 1 wherein R 2 is selected from aminoalkyl moieties.
3. A method for selective inhibition of neuronal nitric oxide synthase, said method comprising:
providing a compound of a formula
wherein R 1 is a substituted alkyl moiety, said R 1 substituents selected from amino, hydroxy and phenyl substituents; and R 2 is a substituted alkyl moiety, said R 2 substituents selected from hydroxy, amino, alkylamino, pyrrolindinyl, alkoxycarbonyl, alkylamido, carbamoyl, pyridinyl, phenylalkyl and phenyl substituents and combinations of said substituents; and salts thereof; and
contacting a nitric oxide synthase with said compound, said contact selectively inhibiting neuronal nitric oxide synthase over inducible and endothelial synthase isoforms.
4. The method of claim 3 wherein R 1 is selected from aminoalkyl moieties.
5. The method of claim 4 wherein R 2 comprises an amino group.