CBLB for treating endotoxin-mediated disorders
View Patent ↗Methods of treating endotoxin-mediated disorders are provided.
1. A method of treating an endotoxin-mediated disorder or symptom thereof, comprising the step of administering an amount of E3 ubiquitin ligase Cblb effective to treat the endotoxin- mediated disorder or symptom thereof.
2. The method of claim 1 wherein the endotoxin-mediated disorder is sepsis.
3. The method of claim 1 further comprising co-administering a modulator of an immune response.
4. The method of claim 3 wherein the modulator is a stimulator of an immune response.
5. The method of claim 4 wherein the stimulator of an immune response is a cytokine.
6. The method of claim 3 wherein the modulator is an inhibitor of an immune response.
7. The method of claim 1 wherein the symptom is acute lung injury.
8. The method of claim 1 wherein the endotoxin-mediated disorder is selected from the group comprising multi-organ dysfunction syndrome (MODS), kidney failure, and liver failure.