Differentiation and identification of analogous chemical and biological substances with biosensors
A biosensor for detecting particular substances biosensor comprises a piezoelectric material, an input transducer supported by the piezoelectric material to receive an input signal and propagate a corresponding acoustic wave within the piezoelectric material and an output transducer supported by the piezoelectric material to receive the acoustic wave. At least two chemically orthogonal or semi-orthogonal biolayers are supported by the piezoelectric material to receive substances to be tested and cause corresponding changes in the acoustic wave. The output transducer can transmit a corresponding output signal embodying separate channel data indicative of the substances received.
1. A biosensor for detecting particular substances, comprising:
a piezoelectric material;
an input transducer supported by the piezoelectric material to receive an input signal and propagate a corresponding acoustic wave within the piezoelectric material;
at least two chemically orthogonal or semi-orthogonal biolayers supported by the piezoelectric material to receive substances to be tested and cause corresponding changes in the acoustic wave; and
an output transducer supported by the piezoelectric material to receive the acoustic wave and transmit a corresponding output signal embodying separate channel data indicative of the substances received.
2. A biosensor according to claim 1 wherein each transducer is an interdigital transducer.
3. A biosensor according to claim 1 wherein each biolayer is located on an interdigital transducer.
4. A biosensor according to claim 1 wherein an array of reflectors causes a corresponding change in the acoustic wave.
5. A biosensor according to claim 4 wherein each biolayer is located on a reflector.
6. A biosensor according to claim 1 wherein each biolayer is located directly on the piezoelectric material.
7. A biosensor according to claim 1 wherein each biolayer comprises a receptor site, which is chemically orthogonal or semi-orthogonal to a receptor site of the other biolayer.
8. A biosensor according to claim 7 wherein each receptor site comprises an antibody, which is chemically orthogonal or semi-orthogonal to an antibody comprising the receptor site of the other biolayer.