Method of coating a stent with a polysaccharide layer and associated stents
View Patent ↗The invention concerns methods of coating stents and stents produced in accordance therewith. The object of the invention is to provide methods of coating stents with a polysaccharide layer which has improved adhesion capacity on the substrate surface of the implant, and to afford correspondingly functionalized stents. That is achieved inter alia by covalent bonding of a non-crosslinked hyaluronic acid to a substrate surface of the stent with the formation of hyaluronic acid layer and crosslinking of the hyaluronic acid layer.
1. A method of coating a surface of a stent with a polysaccharide layer the method comprising the steps of:
providing the stent with a surface prepared for covalent bonding of a polysaccharide thereto;
bonding a non-crosslinked hyaluronic acid covalently to the prepared surface, thereby providing a first non-crosslinked hyaluronic acid layer;
covalent bonding of a crosslinked layer of hyaluronic acid to the first non-crosslinked hyaluronic acid layer; wherein an active substance is present in at least one of the polysaccharide layers.
2. A method of coating a surface of a stent with a polysaccharide layer, the method comprising the steps of:
providing a stent with a surface prepared for the bonding of polysaccharide thereto by bonding a bonding agent layer to the substrate surface;
covalent bonding of a non-crosslinked first layer of chitosan to the bonding agent layer forming a chitosan layer;
bonding a layer of crosslinked hyaluronic acid covalently to the non-crosslinked chitosan; wherein an active substance is provided in at least one of the polysaccharide layers.
3. A method according to claim 2 , wherein:
the active substance is provided by means of a spraying or immersion process prior to the step of bonding a layer of crosslinked hyaluronic acid covalently to the chitosan.
4. A method according to claim 2 , wherein:
the active substance is embedded after crosslinking and fixing of the polysaccharide layers in the swollen condition.
5. The method according claim 4 , wherein:
the active substance is Cyclosporin.
6. The method according claim 2 , wherein:
the active substance is Cyclosporin.
7. The method according claim 2 , wherein the active substance is embedded by means of a spraying or immersion process during coating with the polysaccharide.
8. The method according claim 7 , wherein:
the active substance is Cyclosporin.
9. A method according to claim 2 , wherein:
the secondary layer is thicker than the first polysaccharide layer.
10. A method according to claim 9 , wherein:
the active substance is provided by means of a spraying or immersion process prior to the step of bonding a layer of crosslinked hyaluronic acid covalently to the chitosan.
11. The method according claim 10 , wherein:
the active substance is Cyclosporin.
12. The method according claim 9 , wherein:
the active substance is Cyclosporin.
13. The method according claim 9 , wherein the active substance is embedded by means of a spraying or immersion process during coating with the polysaccharide.
14. The method according claim 13 , wherein:
the active substance is Cyclosporin.
15. A method of coating a surface of a stent with a polysaccharide layer, the method comprising the steps of:
providing a stent with a surface prepared for the bonding of polysaccharide thereto by bonding a bonding agent layer to the substrate surface;
covalent bonding of a non-crosslinked first layer of chitosan to the bonding agent layer forming a chitosan layer;
bonding a layer of non-crosslinked hyaluronic acid covalently to the chitosan;
embedding an active substance in the polysaccharide layers.
16. A method according to claim 15 wherein:
the secondary layer is thicker than the first polysaccharide layer.
17. A method according to claim 15 , wherein:
the active substance is embedded after crosslinking and fixing of the polysaccharide layers in the swollen condition.
18. A method according to claim 15 , wherein:
the active substance is provided by means of a spraying or immersion process prior to the step of bonding a layer of crosslinked hyaluronic acid covalently to the chitosan.
19. The method according claim 15 , wherein the active substance is embedded by means of a spraying or immersion process during coating with the polysaccharide.
20. The method according claim 15 , wherein:
the active substance is Cyclosporin.