Imidazolopyrazine compounds useful for the treatment of degenerative and inflammatory diseases
Novel imidazo[1,2-a]pyrazine compounds are disclosed that have a formula represented by the following: The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, arthritis, inflammation, and others.
1. A compound selected from
4-[5-(1H-Pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-ylamino]-cyclohexanol;
(1H-Indol-5-yl)-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine; and
4-[8-(1H-Indol-5-ylamino)-imidazo[1,2-a]pyrazin-5-yl]-benzamide; and
pharmaceutically acceptable salts thereof.
2. A compound selected from (1H-Indol-5-yl)-[5-(1H-pyrazol-4-yl)-imidazo[1,2-a]pyrazin-8-yl]-amine; and
pharmaceutically acceptable salts thereof.
3. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of claim 1 .
4. The pharmaceutical composition of claim 3 , wherein the carrier is a parenteral carrier.
5. The pharmaceutical composition of claim 3 , wherein the carrier is an oral carrier.
6. The pharmaceutical composition of claim 3 , wherein the carrier is a topical carrier.
7. A method of treatment of rheumatoid arthritis, which comprises administering to a subject in need thereof, a therapeutically effective amount of a compound according to claim 1 .
8. A method of treatment of rheumatoid arthritis, which comprises administering to a subject in need thereof, a therapeutically effective amount of a compound according to claim 2 .
9. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound of claim 2 .
10. The pharmaceutical composition of claim 9 , wherein the carrier is a parenteral carrier.
11. The pharmaceutical composition of claim 9 , wherein the carrier is an oral carrier.
12. The pharmaceutical composition of claim 9 , wherein the carrier is a topical carrier.