Use of nanomaterials based on titanium dioxide and zirconium diozide as coatings for osteointegrated biomedical prostheses, and osteointegrated biomedical prostheses prepared therewith
View Patent ↗Materials and methods, for preparation of coatings based on titanium dioxide for osteointegrated biomedical prostheses. The coatings may comprise nanomaterials having antibacterial properties. For example, an endo-osseous implant is provided with a coating comprised of nanocrystalline material comprising nanoparticles of formula (I) (L-Me n+ ) i, (I) where AO x represents TiO 2 or ZrO 2 ; Me n+ is a metallic ion having antibacterial activity, with n=1 or 2; L is a bi functional organic molecule which can simultaneously bind to the metal oxide and to the metallic ion Me n+ , and i is the number of L-Me n+ groups bound to one nanoparticle of AO x .
1. An endo-osseous implant comprised of biocompatible metallic materials, characterized in that said implant comprises a coating comprised of nanocrystalline material comprising nanoparticles of formula (I):
AO x -(L-Me n+ ) i , (I)
where AO x represents TiO 2 or ZrO 2 ;
Me n+ is a metallic ion having antibacterial activity,
with n=1 or 2;
L is a bifunctional organic molecule which can simultaneously bind to the metal oxide and to the metallic ion Me n+ ; and
i is the number of L-Me n+ groups bound to one nanoparticle of AO x , wherein
L is 4-mercaptophenylboronic acid wherein AO x is functionalized with 4-mercapotophenylboronic acid and 4-mercaptophenylboronic acid binds Me n+ .
2. The endo-osseous implant according to claim 1 , wherein the metallic ion having antibacterial activity is selected from the group consisting of Ag + , Zn ++ , and Cu ++ .
3. The endo-osseous implant according to claim wherein the TiO 2 is in the allotropic form of anatase.
4. The endo-osseous implant according to claim 1 , wherein the coating comprised of nanocrystalline material is transparent.
5. The endo-osseous implant according to claim 1 , wherein i represents the number of ligand molecules L with which the nanoparticle of AO x can bind when said nanoparticle is placed in contact with a solution of the ligand L for a period between 10 minutes and 72 hours.
6. The endo-osseous implant according to claim 1 , wherein the nanoparticles have particle sizes less than 40 nm (nanometers).
7. The endo-osseous implant according to claim 1 , wherein the nanoparticles have particle sizes less than 30 nm.
8. The endo-osseous implant according to claim 1 , wherein the nanocrystalline material is adsorbed onto the surface of said endo-osseous implant.
9. The endo-osseous implant according to claim 1 ; wherein a primer is interposed between the surface of the endo-osseous implant and the nanoparticles of formula (I), which primer is intended to promote the fixation of said nanoparticles to the surface of the implant.
10. The endo-osseous implant according to claim 9 ; wherein said primer is based on peroxytitanic acid, or comprises products based on nanocrystalline titanium;
or is based on organic products.
11. The endo-osseous implant according to claim 1 , wherein the coating comprised of nanocrystalline material is comprised of cationic surfactants having antibacterial activity.
12. The endo-osseous implant according to claim 11 , wherein the cationic surfactants are capable of adsorbing onto the surface of the nanoparticles of formula AO x .
13. The endo-osseous implant according to claim 12 , wherein the cationic surfactants are selected from the group consisting of
benzyl dodecyl dimethylammonium chloride, benzyl hexadecyl dimethylammonium chloride, and benzalkonium chloride.
14. The endo-osseous implant according to claim 1 , wherein the coating comprised of nanocrystalline material is obtained by means of dip coating or spray coating, followed by drying at ambient temperature, and successive heating to a temperature in the range 50-600° C.
15. A method of making a coating on a medical device, comprising a coating having antibacterial properties, antiviral properties, or both antibacterial and antiviral properties on a coating on a medical device,
the coating comprising nanoparticles of formula (I):
AO x -(L-Me n+ ) i , (I)
where AO x represents TiO 2 or ZrO 2 ;
Me n+ is a metallic ion having antibacterial activity,
with n=1 or 2;
L is a bifunctional organic molecule which can simultaneously bind to the metal oxide and to the metallic ion Me n+ ; and
i is the number of L-Me n+ groups bound to one nanoparticle of AO x ;
wherein L is 4-mercaptophenylboronic acid
wherein AO x is functionalized with 4-mercapotophenylboronic acid and 4-mercaptophenylboronic acid binds Me n+ .
16. A method according to claim 15 , wherein the antibacterial, antiviral, or antibacterial and antiviral properties are present in the absence of luminous radiation.
17. The endo-osseous implant according to claim 1 , wherein the nanoparticles have particle sizes less than 15 nm.
18. The endo-osseous implant according to claim 1 , wherein the coating comprised of nanocrystalline material is obtained by means of dip coating or spray coating, followed by drying at ambient temperature, and successive heating to a temperature in the 200-500° C. in the presence of oxygen.