Human transmembrane proteins
The invention provides human transmembrane proteins (HTMPN) and polynucleotides which identify and encode HTMPN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with expression of HTMPN.
1. An isolated polynucleotide encoding a polypeptide comprising an amino acid sequence having at least about 95% sequence identity to the full-length of SEQ ID NO: 74.
2. The isolated polynucleotide of claim 1 , wherein the polypeptide comprises SEQ ID NO: 74.
3. The isolated polynucleotide of claim 1 comprising SEQ ID NO: 153.
4. A recombinant polynucleotide comprising a promoter sequence operably linked to the polynucleotide of claim 1 .
5. An isolated cell transformed with the recombinant polynucleotide of claim 4 .
6. A method of producing the polypeptide encoded by the polynucleotide of claim 1 , the method comprising:
a) culturing a cell under conditions suitable for expression of the polypeptide, wherein said cell is transformed with a recombinant polynucleotide, and said recombinant polynucleotide comprise a promoter sequence operably linked to the polynucleotide of claim 1 , and
b) recovering the polypeptide so expressed.
7. The method of claim 6 , wherein the polypeptide comprises SEQ ID NO: 74.
8. The method of claim 6 , wherein the polynucleotide comprises SEQ ID NO: 153.