Sialoadhesin factor-2 antibodies
Monoclonal antibodies have been generated that bind to human sialoadhesion factor-2. These antibodies are useful as diagnostic and therapeutic reagents.
1. A humanized antibody comprising complementarity determining regions set forth in SEQ ID NOs:5, 6, 7, 8, 9 and 10, wherein said antibody binds to human SAF-2.
2. A chimeric antibody comprising complementarity determining regions set forth in SEQ ID NOs:5, 6, 7, 8, 9 and 10, wherein the antibody binds to human SAF-2.
3. A hybridoma cell line that produces a monoclonal antibody comprising complementarity determining regions set forth in SEQ ID NOs:5, 6, 7, 8, 9 and 10.
4. A pharmaceutical composition comprising an antibody comprising complementarity determining regions set forth in SEQ ID NOs:5, 6, 7, 8, 9 and 10.
5. A pharmaceutical composition comprising the antibody of claim 1 .
6. A pharmaceutical composition comprising the monoclonal antibody of claim 2 .
7. An antibody fragment selected from the group consisting of an Fv fragment, an Fab fragment, and Fab′ fragment, and an F(ab′) 2 fragment, wherein the fragment comprises a heavy chain variable region of SEQ ID NO:2 and a light chain variable region of SEQ ID NO:4.
8. An engineered antibody comprising complementarity determining regions set forth in SEQ ID NOs:5, 6, 7, 8, 9 and 10, wherein the engineered antibody binds to human SAF-2.