Substituted porphyrins
View Patent ↗The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
1. A method for treating a patient for inflammation of the lung, said method comprising administering to a patient in need an effective amount of a compound of formula
or pharmaceutically accept salt thereof,
wherein
R 1 and R 3 are the same and are:
—H, —CF 3 , —CO 2 X,
R 2 and R 4 are the same and are:
Y is halogen or —CO 2 X,
each X is the same or different and is an alkyl; and
each R 5 is the same or different and is H or alkyl.
2. The method according to claim 1 , wherein said inflammation of the lung is an inflammatory lung disease.
3. The method according to claim 1 , wherein said inflammation of the lung is an inflammatory based disorder of asthma, emphysema, acute respiratory distress syndrome (ARDS), pneumonia, cystic fibrosis, or bronchopulmonary dysplasia.
4. The method according to claim 1 , wherein said inflammation of the lung comprises respiratory fatigue.
5. The method according to claim 4 , wherein said inflammation of the lung is chronic obstructive pulmonary disease.
6. The method according to claim 1 , wherein said inflammation of the lung comprises the pulmonary system.
7. The method according to claim 6 , wherein said inflammation of the lung is pulmonary fibrosis or pulmonary hypertension.
8. The method according to claim 3 , wherein said inflammation of the lung is asthma, emphysema, ARDS or pneumonia.
9. The method according to claim 3 , wherein said inflammation of the lung is bronchopulmonary dysplasia.
10. The method according to claim 1 , wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.
11. The method according to claim 10 , wherein said compound is complexed with manganese.
12. The method according to claim 1 , wherein
R 1 and R 3 are —H, —CF 3 , —CO 2 X,
or
R 2 and R 4 are
Y is —F or —CO 2 X;
X is the same or different and is a C 1-4 alkyl; and
each R 5 is the same or different and is H or C 1-4 alkyl.
13. The method according to claim 12 , wherein X is methyl or ethyl.
14. The method according to claim 12 , wherein R 1 , R 2 , R 3 and R 4 are the same.
15. The method according to claim 14 , wherein
R 1 , R 2 , R 3 and R 4 are
or
16. The method according to claim 15 , wherein X is methyl or ethyl.
17. The method according to claim 16 , wherein said compound is
18. The method according to claim 12 , wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.
19. The method according to claim 18 , wherein said compound is complexed with manganese.
20. The method according to claim 19 , wherein said compound is