Peritoneal dialysis method
A peritoneal dialysate containing adenosine triphosphate or a salt thereof, and a peritoneal dialysis method using the dialysate. The peritoneal dialysate is safe and causes less peritoneal injuries even when employed in peritoneal dialysis over a long period of time.
1. A peritoneal dialysis method comprising:
administering into the peritoneum of a patient having uremia or renal failure a dialysate comprising adenosine triphosphate or a salt thereof; and subsequently
discharging said dialysate from the peritoneum.
2. The peritoneal dialysis method of claim 1 ,
wherein said patient is suffering from a renal disease, and
said dialysate is administered intraperitoneally via a catheter implanted in the peritoneal cavity.
3. The peritoneal dialysis method of claim 1 or 2 , wherein the concentration of adenosine triphosphate or a salt thereof in the dialysate ranges from 10 to 5,000 μM.
4. The peritoneal dialysis method of claim 1 or 2 , wherein the dialysate further comprises glucose and an electrolyte.
5. The peritoneal dialysis method of claim 4 , wherein the glucose level ranges from 1,000 to 4,000 mg/dL.
6. The peritoneal dialysis method of claim 1 , further comprising:
administering a dialysate containing a high level of glucose into a patient suffering a renal disease through a catheter implanted in the peritoneal cavity after administering said dialysate containing adenosine triphosphate or a salt thereof and a physiological level of glucose.
7. The peritoneal dialysis method of claim 6 , wherein the physiological glucose level ranges from 0.08 to 0.16% (w/v) and the high glucose level ranges from 1,000 to 4,000 mg/dL.
8. A method for treating peritoneal injury in a subject having uremia and undergoing repeated dialysis with a peritoneal dialysate containing glucose, comprising administering an effective amount of adenosine triphosphate or a salt thereof into the peritoneum of said subject.
9. A treating method for peritoneal cell injury caused by sugar, comprising administering into the peritoneum of a subject in need thereof an effective amount of adenosine triphosphate or a salt thereof to a subject in need thereof.
10. The method as described in claim 9 , wherein the cell injury caused by sugar is peritoneal mesothelial cell injury caused by glucose.
11. A peritoneal dialysis method comprising:
administering into the peritoneal cavity of a subject having uremia an effective amount of a composition comprising adenosine triphosphate or a salt thereof; and subsequently
discharging said dialysate from the peritoneal cavity.
12. The method of claim 11 , wherein said composition further comprises glucose and electrolytes.
13. The method of claim 11 , wherein said composition contains:
10 to 5,000 μM of adenosine triphosphate or a salt thereof,
1,000 to 4,000 mg/dL glucose,
100 to 200 mEq/L Na + ,
4 to 5 mEq/L Ca 2+ ,
1 to 2 mEq/L Mg 2+ , and
80 to 120 mEq/L Cl − .
14. The method of claim 13 , wherein said composition also contains 30 to 50 mEq/L of an organic acid.
15. The method of claim 13 , wherein said composition also contains 30 to 50 mEq/L of lactic acid.
16. The method of claim 11 , wherein said composition has an osmotic pressure ranging between 300 and 700 mOsm/L.
17. The method of claim 11 , wherein said subject has renal failure.
18. The method of claim 11 , wherein said subject has peritoneal mesothelial cell injuries caused by exposure to high levels of sugar.
19. The method of claim 11 , wherein said subject has hardening of the peritoneum or peritonitis.
20. The method of claim 11 , wherein said subject has sclerotic encysted peritonitis or intractable prolonged peritonitis.
21. The method of claim 8 , comprising administering a solution containing:
adenosine triphosphate or a salt thereof,
1,000 to 4,000 mg/dL glucose, and
electrolytes.
22. The method of claim 9 , comprising administering a solution containing:
adenosine triphosphate or a salt thereof,
1,000 to 4,000 mg/dL glucose, and
electrolytes.
23. A peritoneal dialysis method comprising:
administering into the peritoneal cavity of a patient in need of dialysis a dialysate comprising adenosine triphosphate or a salt thereof; and subsequently
discharging said dialysate from the peritoneal cavity.
24. The peritoneal dialysis method of claim 23 , further comprising a step of adding adenosine triphosphate to a conventional peritoneal dialysis solution that does not contain adenosine triphosphate to produce a dialysate and then administering said dialysate to a patient in need thereof.
25. The peritoneal dialysis method of claim 23 , wherein the dialysate contains 10 to 5,000 μM of adenosine triphosphate.
26. The peritoneal dialysis method of claim 23 , wherein said patient has hardening of the peritoneum or peritonitis or other damage to the peritoneum characterized by mesothelial cell injury caused by prior exposure to a peritoneal dialysis solution that does not contain adenosine triphosphate.