Nitric oxide releasing compounds
View Patent ↗Compositions comprising nitrosyl-cobinamide are provided. Also provided are methods for treating hypertension, which comprise administering therapeutically effective amounts of nitrosyl-cobinamide. Also provided are methods for producing nitrosyl-cobinamide.
1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound having the formula I:
2. A method for treating hypertension in a subject in need of such treatment, comprising administering to the subject a composition comprising a pharmaceutically acceptable carrier and the compound of claim 1 in an amount effective to treat hypertension in the subject.
3. The method of claim 2 , wherein the subject is a mammal.
4. The method of claim 3 , wherein the mammal is a human.
5. A method for preparing nitrosyl-cobinamide comprising;
deoxygenating cobinamide to produce a deoxygenated cobinamide, reducing the deoxygenated cobinamide with a weak reducing agent to produce a reduced cobinamide, saturating the reduced cobinamide with NO, and removing unreacted NO.
6. The method of claim 5 , wherein the weak reducing agent is deoxygenated ascorbic acid.
7. The method of claim 2 , wherein the pharmaceutical composition of claim 1 is co-administered with another therapeutic agent.
8. The method of claim 7 , wherein the therapeutic agent is administered before the pharmaceutical composition of claim 1 .
9. The method of claim 7 , wherein the said therapeutic agent is administered simultaneously with the pharmaceutical composition of claim 1 .
10. The method of claim 7 , wherein the said therapeutic agent is administered after the pharmaceutical composition of claim 1 .