Group B
Group B streptococcus (GBS) proteins and polynucleotides encoding them are disclosed. Said proteins are antigenic and therefore useful vaccine components for the prophylaxis or therapy of streptococcus infection in animals. Also disclosed are recombinant methods of producing the protein antigens as well as diagnostic assays for detecting streptococcus bacterial infection.
1. An isolated polypeptide comprising an amino acid sequence at least 95% identical to the amino acid sequence set forth in either SEQ ID NO:15 or SEQ ID NO:16.
2. The isolated polypeptide according to claim 1 , wherein the polypeptide comprises the amino acid sequence set forth in either SEQ ID NO:15 or SEQ ID NO:16.
3. An immunogenic composition comprising the isolated polypeptide according to claim 1 and (a) a pharmaceutically acceptable carrier or diluent; or (b) a pharmaceutically acceptable adjuvant and a pharmaceutically acceptable carrier or diluent.
4. An immunogenic composition comprising the isolated polypeptide according to claim 2 and (a) a pharmaceutically acceptable carrier or diluent; or (b) a pharmaceutically acceptable adjuvant and a pharmaceutically acceptable carrier or diluent.