Injectable, injection solution, and injection kit preparation
Provided is an injectable comprising: an anthracycline antineoplastic antibiotic; and at least one acid amide selected from the group consisting of nicotinic acid amide, isonicotinic acid amide and gentisic acid ethanolamide.
1. An injectable composition comprising:
an anthracycline antineoplastic antibiotic; and
at least one acid amide selected from the group consisting of nicotinic acid amide, isonicotinic acid amide and gentisic acid ethanolamide in an amount sufficient to dissolve the antibiotic in a dissolution solution faster than if the acid amide were not present.
2. The injectable composition according to claim 1 , wherein the anthracycline antineoplastic antibiotic is at least one substance selected from the group consisting of aclarubicin hydrochloride, amrubicin hydrochloride, idarubicin hydrochloride, epirubicin hydrochloride, daunorubicin hydrochloride, doxorubicin hydrochloride, pirarubicin hydrochloride and mitoxantrone hydrochloride.
3. The injectable composition according to claim 1 , wherein a content of the acid amide is 0.75 mg to 12.5 mg per mg (titer) of the anthracycline antineoplastic antibiotic.
4. An injection solution comprising:
an anthracycline antineoplastic antibiotic;
at least one acid amide selected from the group consisting of nicotinic acid amide, isonicotinic acid amide and gentisic acid ethanolamide in an amount sufficient to dissolve the antibiotic in a dissolution solution faster than if the acid amide were not present; and
the dissolution solution.
5. An injection kit preparation comprising:
a freeze-dried injectable of an anthracycline antineoplastic antibiotic; and
a dissolution solution containing at least one acid amide selected from the group consisting of nicotinic acid amide, isonicotinic acid amide and gentisic acid ethanolamide in an amount sufficient to dissolve the antibiotic in the dissolution solution faster than if the acid amide were not present.
6. An injection kit preparation comprising:
a freeze-dried injectable of an anthracycline antineoplastic antibiotic; and
a container filled with at least one acid amide selected from the group consisting of nicotinic acid amide, isonicotinic acid amide and gentisic acid ethanolamide in an amount sufficient to dissolve the antibiotic in a dissolution solution faster than if the acid amide were not present.