Multi-functional ionic liquid compositions for overcoming polymorphism and imparting improved properties for active pharmaceutical, biological, nutritional, and energetic ingredients
View Patent ↗Disclosed are ionic liquids and methods of preparing ionic liquid compositions of active pharmaceutical, biological, nutritional, and energetic ingredients. Also disclosed are methods of using the compositions described herein to overcome polymorphism, overcome solubility and delivery problems, to control release rates, add functionality, enhance efficacy (synergy), and improve ease of use and manufacture.
1. A composition comprising at least one kind of cation and at least one kind of anion, wherein one or more cations are selected from the group consisting of lidocaine, procaine, benzocaine, bupivacaine, chloroprocaine, dexivacaine, diamocaine, dibucaine, etidocaine, propoxycaine, risocaine, rodocaine, and tetracaine, wherein one or more anions are selected from the group consisting of docusate, ibuprofen, acetate, and sulfacetamide, wherein the ratio of cations and anions results in a balance of charge, and wherein the composition is an ionic liquid that is liquid at a temperature at or below about 37° C. and the ionic liquid is substantially free of water wherein the anion and cation does not result in procaine acetate.
2. The composition of claim 1 , wherein the composition is liquid at about 25° C.
3. The composition of claim 1 , wherein the composition is liquid at about 37°C.
4. The composition of claim 1 , wherein the cation is lidocaine and the anion is docusate.
5. The composition of claim 1 , wherein the cation is lidocaine and the anion is ibuprofen.
6. The composition of claim 1 , wherein the cation is lidocaine and the anion is sulfacetamide
7. The composition of claim 1 , wherein the cation is lidocaine and the anion is acetate.
8. The composition of claim 1 , wherein the cation is procaine and the anion is docusate.
9. The composition of claim 1 , wherein the cation is procaine and the anion is ibuprofen.