Vascular therapeutics
The present invention provides a method of preventing or reducing restenosis, neointima formation, graft failure, atherosclerosis, angiogenesis and/or solid tumor growth in a subject The method comprises administering to the subject a prophylactically effective dose of a nucleic acid which decreases the level of c-Jun mRNA, c-Jun mRNA translation or nuclear accumulation or activity of c-Jun. It is preferred that the nucleic acid is a DNAzyme that targets c-Jun mRNA.
1. A method of reducing ocular angiogenesis in a subject, the method comprising administering to the eye of the subject a pharmaceutical composition comprising an effective dose of a DNAzyme targeted against c-Jun, wherein the DNAzyme has the sequence of SEQ ID NO:5.
2. The method according to claim 1 wherein the DNAzyme incorporates a 3′-3′ inversion at the 3′ terminus.