IP Library › Granted Patent US 8,242,141
Granted Patent B2
US 8,242,141 · App. 12/882,904 · Granted Aug 14, 2012

Compositions and methods for treating seizure disorders

Assignee: Allergan, Inc.
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Quick Facts
Patent No.
US 8,242,141
App. No.
12/882,904
Granted
Aug 14, 2012
Kind
B2
Abstract

Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:

Claims (12)

1. A method for treating epilepsy, the method comprising the step of administering to a patient in need of such treatment a compound having the following structure:

or a pharmaceutically acceptable salt thereof, wherein:

X is CH 2 or CH 2 —CH 2 ,

A is aryl, or is heteroaryl having 1, 2, or 3 atoms selected from the group consisting of N, S, and O,

wherein A has 0, 1, 2, or 3 substituents each comprising 0 to 8 carbon atoms, 0 to 3 oxygen atoms, 0 to 3 halogen atoms, 0 to 2 nitrogen atoms, 0 to 2 sulfur atoms, and 0 to 24 hydrogen atoms.

2. The method of claim 1 , wherein A is selected from the group consisting of pyridinyl, thienyl, furyl, quinolinyl, methylphenyl, and biphenyl.

3. The method of claim 2 , wherein A is unsubstituted.

4. The method of claim 2 , wherein the epilepsy is juvenile myoclonic epilepsy, complex status epilepticus, partial status epilepticus, reflex epilepsy, childhood absence epilepsy, or Lennox-Gastaut syndrome.

5. A method of treating epilepsy in a patient, comprising administering to said patient in need thereof, at least one compound selected from the group consisting of

or a pharmaceutically acceptable salt thereof.

6. A method of treating epilepsy in a patient, comprising administering to said patient in need thereof, a compound of the formula

or a pharmaceutically acceptable salt thereof.

Continuity (3)
Provisional Application 61243057 · Sep 16, 2009
Provisional Application 61246226 · Sep 28, 2009
Related Publication 20110065747A1 · Mar 17, 2011