Compositions and methods for treating seizure disorders
Disclosed are methods of treating a seizure disorder by administering to a patient in need of such treatment a compound having the following formula:
1. A method for treating epilepsy, the method comprising the step of administering to a patient in need of such treatment a compound having the following structure:
or a pharmaceutically acceptable salt thereof, wherein:
X is CH 2 or CH 2 —CH 2 ,
A is aryl, or is heteroaryl having 1, 2, or 3 atoms selected from the group consisting of N, S, and O,
wherein A has 0, 1, 2, or 3 substituents each comprising 0 to 8 carbon atoms, 0 to 3 oxygen atoms, 0 to 3 halogen atoms, 0 to 2 nitrogen atoms, 0 to 2 sulfur atoms, and 0 to 24 hydrogen atoms.
2. The method of claim 1 , wherein A is selected from the group consisting of pyridinyl, thienyl, furyl, quinolinyl, methylphenyl, and biphenyl.
3. The method of claim 2 , wherein A is unsubstituted.
4. The method of claim 2 , wherein the epilepsy is juvenile myoclonic epilepsy, complex status epilepticus, partial status epilepticus, reflex epilepsy, childhood absence epilepsy, or Lennox-Gastaut syndrome.
5. A method of treating epilepsy in a patient, comprising administering to said patient in need thereof, at least one compound selected from the group consisting of
or a pharmaceutically acceptable salt thereof.
6. A method of treating epilepsy in a patient, comprising administering to said patient in need thereof, a compound of the formula
or a pharmaceutically acceptable salt thereof.