MHC molecule-binding tumor-associated peptides
The invention relates to a tumor-associated peptide with an amino acid sequence selected from the group consisting of SEQ ID NO. 1 to SEQ ID NO. 577 from the attached sequence protocol, the peptide being capable of binding to a molecule of the human major histocompatibility complex (MHC) class I. The invention further relates to the use of the peptides for preparation of a drug and for the treatment of tumor diseases and/or adenomatous diseases. Furthermore, a pharmaceutical composition is described comprising at least one of the peptides.
1. An isolated peptide consisting of:
(a) SEQ ID NO: 303; or
(b) SEQ ID NO: 303 with the proviso that:
(b1) not more than one additional amino acid is added at the N-terminus of SEQ ID NO: 303; and/or
(b2) not more than one additional amino acid is present at the C-terminus of SEQ ID NO: 303; and
the peptide being capable of binding to a molecule of human major histocompatibility complex (MHC) class I.
2. The peptide of claim 1 consisting of SEQ ID NO: 303.
3. A composition comprising the peptide of claim 1 .
4. The composition of claim 3 , wherein the peptide consists of SEQ ID NO: 303.
5. The composition according to claim 3 further comprising at least one pharmaceutically acceptable carrier, and/or at least one excipient, and/or at least one immunostimulatory substance.