IP Library › Granted Patent US 8,247,559
Granted Patent B2
US 8,247,559 · App. 13/047,309 · Granted Aug 21, 2012

Process for preparing an intermediate to mu opioid receptor antagonists

Assignee: Theravance, Inc.
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Quick Facts
Patent No.
US 8,247,559
App. No.
13/047,309
Granted
Aug 21, 2012
Kind
B2
Abstract

The invention provides an efficient method for preparing 3-endo-(8-azabicyclo[3.2.1]oct-3-yl)benzamide by hydrogenation, under controlled conditions, of an amino-protected 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)benzamide intermediate in which the amino-protecting group is removable by catalytic hydrogenation.

Claims (4)

1. A compound of formula 2

having the chemical name 3-(8-azabicyclo[3.2.1]oct-2-en-3-yl)benzamide.

2. A compound of formula 3:

wherein P 1 is tert-butoxycarbonyl.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 5, 2014
From: THERAVANCE, INC.
To: THERAVANCE BIOPHARMA R&D IP, LLC
Reel/Frame 033127/0180 →
Continuity (3)
Division 12218383 · Jul 15, 2008
Provisional Application 60961353 · Jul 20, 2007
Related Publication 20110166355A1 · Jul 7, 2011