IP Library › Granted Patent US 8,257,970
Granted Patent B2
US 8,257,970 · App. 11/856,466 · Granted Sep 4, 2012

Method for activating natural killer cells by tumor cell preparation in vitro

Assignee: UCL Biomodica PLC
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Quick Facts
Patent No.
US 8,257,970
App. No.
11/856,466
Granted
Sep 4, 2012
Kind
B2
Abstract

The present invention provides a method for activating a Natural Killer (NK) cell by contacting the NK cell in vitro with an activating tumor cell preparation (ATCP). The invention also provides an activated NK cell produced by such a method and its use in the treatment of cancer.

Claims (5)

1. A method for activating a human Natural Killer (NK) cell, which comprises the step of contacting the human NK cell in vitro with an activating tumor cell preparation (ATCP) comprising intact tumor cells or a membrane preparation thereof; wherein said contact activates said human NK cell to lyse a target cell previously resistant to NK-cell lysis.

2. A method according to claim 1 , wherein the ATCP comprises CTV-1 myeloid leukemia cells or a membrane preparation thereof.

3. A method according to claim 1 , wherein, during activation, expression of CD69 is upregulated on the NK cell.

4. A method according to claim 1 , wherein the NK cell is autologous.

5. A method according to claim 1 , wherein the NK cell is allogeneic.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2008
From: LOWDELL, MARK
To: UCL BIOMEDICA PLC
Reel/Frame 020574/0772 →
Priority Claims (2)
GB 0505508.2 · Mar 17, 2005 · national
GB 0514288.0 · Jul 12, 2005 · national
Continuity (2)
Continuation In Part PCTGB2006000960 · Mar 16, 2006
Related Publication 20080166326A1 · Jul 10, 2008