Hydrochloride salt of an azabicyclo[3.2.1]octane derivative
The invention relates to a hydrochloride salt of (1R,2R,3S,5S)-3-(3,4-dichlorophenyl)-2-[(methyloxy)methyl]-8-azabicyclo[3.2.1]octane, uses of the salt as a medicament in the treatment inter alia of disorders of the central nervous system and pharmaceutical compositions and dosage forms comprising the salt.
1. A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, which salt has the crystal structure characterized by the following XRPD peak list:
Position
d-spacing
(±0.2 °2theta)
(Angstroms)
6.2
14.2
12.5
7.1
13.5
6.6
15.6
5.7
18.7
4.8.
2. The hydrochloride salt according to claim 1 , which salt has the crystal structure characterized by the following XRPD peak list:
Position
d-spacing
(±0.2 °2theta)
(angstroms)
6.2
14.2
12.5
7.1
13.1
6.7
13.5
6.6
15.6
5.7
16.9
5.2
18.7
4.8
21.7
4.1
22.0
4.0
22.5
3.9
22.8
3.9
24.0
3.7
24.9
3.6
25.1
3.5
25.6
3.5
26.1
3.4
26.7
3.3
27.1
3.3
28.0
3.2
29.9
3.0.
3. The hydrochloride salt according to claim 2 , which salt has the crystal structure characterized by the XRPD spectrum substantially the same as in FIG. 1 .
4. A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, having the crystal structure characterized by a melting endotherm with an onset of 211±3° C. in the DSC thermogram.
5. A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, having the crystal structure characterized by the following absorption peaks in the infrared spectrum of the solid product at 2858, 2767, 2715, 2581, 2503, 1472, 1411, 1368, 1272, 1191, 1137, 1125, 1090, 1058, 1028, 927, 914, 906, 879, 820, 808, 782, 706, 692 and 669±4 cm −1 .
6. The hydrochloride salt according to claim 5 , having the crystal structure characterized by the following absorption peaks in the infrared spectrum of the solid product at 2858, 2767, 2715, 2657, 2581, 2503, 1603, 1564, 1472, 1411, 1385, 1368, 1336, 1286, 1272, 1251, 1191, 1137, 1125, 1090, 1058, 1028, 966, 951, 927, 914, 906, 879, 820, 808, 782, 739, 706, 692 and 669±4 cm −1 .
7. The hydrochloride salt according to claim 6 , having the crystal structure characterized in that it has an infrared spectrum substantially the same as in FIG. 4 .
8. A crystalline anhydrate hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane, having the crystal structure characterized by the following peaks in the Raman spectrum at 3072, 2994, 2980, 2965, 2935, 2905, 2870, 1592, 1462, 1442, 1210, 1028, 907, 880, 820, 670, 530, 486, 460, 432, 395, 318, 240, 201, 171, 143, 94 and 68±4 cm −1 .
9. The hydrochloride salt according to claim 8 , having the crystal structure characterized in that it has a Raman spectrum substantially the same as in FIG. 5 .
10. A method for making a dosage form of the hydrochloride salt according to any one of claim 1 , 4 , 5 , or 8 , the method comprising:
a) adding a metered liquid dose onto each of a plurality of carrier substrates; the liquid dose comprising a hydrochloride salt of (1R,2R,3S,5S)-2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]octane dissolved in a suitable solvent system;
b) evaporating the solvent; and
c) optionally providing a coating over the salt.
11. The hydrochloride salt according to any one of claim 1 , 4 , 5 , or 8 dissolved in a solvent system.
12. A liquid dose comprising the hydrochloride salt according to claim 11 .
13. A pharmaceutical dosage form obtained by the method defined in claim 10 .
14. A pharmaceutical dosage form comprising a carrier substrate and the hydrochloride salt according to any one of claim 1 , 4 , 5 , or 8 .