4-methylpyridopyrimidinone compounds

1. A compound of Formula (I)

or a salt thereof,

wherein:

R 1 is H or (C 1 to C 6 ) alkyl optionally substituted with at least one R 5 group;

A is a 3 to 10 membered cycloalkyl group;

R 2 is (C 1 to C 6 ) alkyl substituted with at least one R 6 group, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, (C 2 to C 9 ) heteroaryl, —NR 7a R 7b , or —N═CR 8a R 8b wherein each of the said (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, and (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group;

R 3 is (C 1 to C 6 ) alkyl, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 2 to C 8 ) alkenyl, (C 2 to C 8 ) alkynyl, halogen, cyano, —(CH 2 ) n C(O)OR 10 , —(CH 2 ) n C(O)N(R 11a R 11b ), COR 12 , (C 6 to C 14 ) aryl, or (C 2 to C 9 ) heteroaryl, wherein said (C 1 to C 6 ) alkyl, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 2 to C 8 ) alkenyl, (C 2 to C 8 ) alkynyl, (C 6 to C 14 ) aryl and (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group;

each R 4 is independently —OH, halogen, CF 3 , —NR 11a R 11b , (C 1 to C 6 ) alkyl, (C 2 to C 6 ) to alkenyl, (C 2 to C 6 ) alkynyl, (C 1 to C 6 ) alkoxy, cyano, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, (C 2 to C 9 ) heteroaryl, —C(O)R 12 , —C(O)NR 11a R 11b , —S(O) m R 12 , —S(O) m NR 11a R 11b , —NR 11a S(O) m R 12 , —(CH 2 ) n C(O)OR 10 , —(CH 2 ) n C(O)N(R 11a R 11b ), —OC(O)R 12 , —NR 11a C(O)R 12 or —NR 11a C(O)N(R 11a R 11b ) wherein each of the said (C 1 to C 6 ) alkyl, (C 2 to C 6 ) alkenyl, (C 2 to C 6 ) alkynyl, (C 1 to C 6 ) alkoxy, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, and (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 13 group;

each R 5 is independently —OH, halogen, CF 3 , —NR 11a R 11b , (C 1 to C 6 ) alkyl, (C 1 to C 6 ) alkoxy, cyano, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, (C 2 to C 9 ) heteroaryl, —S(O) m R 12 , —S(O) m NR 11a R 11b , —C(O)R 12 or —C(O)NR 11a R 11b wherein each of the said (C 1 to C 6 ) alkyl, (C 1 to C 6 ) alkoxy, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, and (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group;

each R 6 is independently —OH, (C 2 to C 6 ) alkynyl, cyano, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, (C 2 to C 9 ) heteroaryl, —C(O)R 12 , —C(O)NR 11a R 11b , —S(O) m R 12 , —S(O) m NR 11a R 11b , —NR 11a S(O) m R 12 , —(CH 2 ) n C(O)OR 10 , —(CH 2 ) n C(O)N(R 11a R 11b ), —OC(O)R 12 , —NR 11a C(O)R 12 or —NR 11a C(O)N(R 11a R 11b ) wherein each of the said (C 2 to C 6 ) alkynyl, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, and (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 13 group;

R 7a and R 7b are each independently H, (C 1 to C 6 ) alkyl, (C 2 to C 6 )alkenyl, (C 2 to C 6 )alkynyl, (C 3 to C 10 ) cycloalkyl, or (C 6 to C 10 )aryl, wherein each of the said (C 1 to C 6 ) alkyl, (C 2 to C 6 )alkenyl, (C 2 to C 6 )alkynyl, (C 3 to C 10 ) cycloalkyl, and (C 6 to C 10 )aryl is optionally substituted with at least one R 9 group; or R 7a and R 7b may be taken together with the nitrogen atom to form a 5 to 8 membered cycloheteroalkyl ring, wherein said heterocyclyl ring has 1 to 3 ring heteroatoms selected from the group consisting of N, O, and S and wherein the said 5 to 8 membered cycloheteroalkyl ring is optionally substituted with at least one R 9 group;

R 8a and R 8b are each independently H, (C 1 to C 6 ) alkyl, or (C 3 to C 10 ) cycloalkyl wherein each of the said (C 1 to C 6 ) alkyl, and (C 3 to C 10 ) cycloalkyl, is optionally substituted with at least one R 9 group;

each R 9 is independently —OH, halogen, CF 3 , —NR 11a R 11b , (C 1 to C 6 ) alkyl, (C 2 to C 6 ) alkenyl, (C 2 to C 6 ) alkynyl, (C 1 to C 6 ) alkoxy, cyano, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, (C 2 to C 9 ) heteroaryl, —C(O)R 12 , —C(O)NR 11a R 11b , —S(O) m R 12 , —S(O) m NR 11a R 11b , —NR 11a S(O) m R 12 , —(CH 2 ) n C(O)OR 10 , —(CH 2 ) n C(O)N(R 11a R 11b ), —OC(O)R 12 , —NR 11a C(O)R 12 or —NR 11a C(O)N(R 11a R 11b ) wherein each of the said (C 1 to C 6 ) alkyl, (C 2 to C 6 ) alkenyl, (C 2 to C 6 ) alkynyl, (C 1 to C 6 ) alkoxy, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, and (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 13 group;

each R 10 is independently H, or (C 1 to C 6 ) alkyl;

R 11a and R 11b are each independently H, (C 1 to C 6 ) alkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 2 to C 9 ) heteroaryl, or (C 6 to C 12 ) aryl wherein each of the said (C 1 to C 6 ) alkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 2 to C 9 ) heteroaryl, and (C 6 to C 12 ) aryl is optionally substituted with at least one R 13 group;

each R 12 is independently (C 1 to C 6 ) alkyl, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 2 to C 9 ) heteroaryl, or (C 6 to C 14 ) aryl wherein each of the said (C 1 to C 6 ) alkyl, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 2 to C 9 ) heteroaryl, and (C 6 to C 14 ) aryl is optionally substituted with at least one R 13 group;

each R 13 is independently —OH, halogen, CF 3 , (C 1 to C 6 ) alkyl, (C 2 to C 6 ) alkenyl, (C 2 to C 6 ) alkynyl, (C 1 to C 6 ) alkoxy, cyano, (C 3 to C 10 ) cycloalkyl, (C 2 to C 9 ) cycloheteroalkyl, (C 6 to C 14 ) aryl, (C 2 to C 9 ) heteroaryl, amino, C-amido, S-sulfonamido, C-carboxyl, N-amido, or N-carbamyl;

each m is independently 1 or 2;

each n is independently 0, 1, 2, 3, or 4; and

each z is independently 0, 1, 2, 3, 4, 5, 6, 7, or 8.

2. The compound or salt according to claim 1 , wherein A is cyclohexyl.

3. The compound or salt according to claim 1 , wherein R 3 is (C 6 to C 14 ) aryl or (C 2 to C 9 ) heteroaryl, wherein said (C 6 to C 14 ) aryl or (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group.

4. A pharmaceutical composition, comprising at least one compound or salt according to claim 1 and a pharmaceutically acceptable carrier or diluent.

5. The compound or salt according to claim 1 , wherein A is selected from the group consisting of cyclobutyl, cyclopentyl, and cyclohexyl.

6. The compound or salt according to 1 , wherein A is selected from the group consisting of cyclobutyl, cyclopentyl, and cyclohexyl; and R 3 is (C 6 to C 14 ) aryl or (C 2 to C 9 ) heteroaryl, wherein said (C 6 to C 14 ) aryl or (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group.

7. The compound or salt according to claim 6 , wherein R 3 is (C 2 to C 9 ) heteroaryl, wherein said (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group.

8. The compound or salt according to claim 7 , wherein A is cyclohexyl.

9. The compound or salt according to claim 6 , wherein and R 3 is (C 6 to C 14 ) aryl, wherein said (C 6 to C 14 ) aryl is optionally substituted with at least one R 9 group.

10. The compound or salt according to claim 9 , wherein A is cyclohexyl.

11. The compound or salt according to claim 1 , wherein:

R 1 is H;

A is selected from the group consisting of cyclobutyl, cyclopentyl, and cyclohexyl;

R 3 is (C 6 to C 14 ) aryl or (C 2 to C 9 ) heteroaryl, wherein said (C 6 to C 14 ) aryl or (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group; and

z is 0.

12. The compound or salt according to claim 11 , wherein R 3 is (C 6 to C 14 ) aryl, wherein said (C 6 to C 14 ) aryl is optionally substituted with at least one R 9 group.

13. The compound or salt according to claim 12 , wherein A is cyclohexyl.

14. The compound or salt according to claim 11 , wherein R 3 is (C 2 to C 9 ) heteroaryl, wherein said (C 2 to C 9 ) heteroaryl is optionally substituted with at least one R 9 group.

15. The compound or salt according to claim 14 , wherein A is cyclohexyl.