Nutritional composition comprising immunoglobulins and oligosaccharides
The present invention provides a method and composition for the treatment and/or prevention of infection, said method comprising orally administering a composition to a mammal, said composition comprising a galactose containing indigestible oligosaccharide and immunoglobulin from the milk or colostrum of hyperimmunized cows.
1. A method of reducing the incidence of upper respiratory tract infection episodes comprising administering to an infant mammal in need thereof a liquid infant formula composition consisting of:
(a) 0.5-10 grams transgalactooligosaccharide per 100 grams dry weight of the composition,
(b) 0.5-10 grams fructopolysaccharide per 100 grams dry weight of the composition,
(c) optionally, indigestible dextrins, xylooligosaccharides, arabinooligosaccharides, glucooligosaccharides, mannooligosaccharides, fucooligosaccharides, fructans, fructooligosaccharide, hydrolysed inulin, inulin or lactose, and
(d) optionally, a long chain polyunsaturated fatty acid (LC-PUFA),
wherein, as a percentage of the total caloric value of the composition, (i) 35-50% energy is derived from fat; (ii) 7.5-12.5% energy is derived from protein; and 40-55% energy is derived from carbohydrate; and
wherein the composition is in the form of a liquid and does not comprise human milk.
2. The method according to claim 1 , wherein the mammal is a human.
3. The method according to claim 1 , wherein the composition is administered orally.
4. The method according to claim 1 , wherein the fat, carbohydrate, or protein is of plant, non-human animal, bacterial, or synthetic origin.
5. The method according to claim 1 , wherein the composition consists of
(a) 2-5 grams transgalactooligosaccharide per 100 grams dry weight of the composition, and
(b) 1-5 grams fructopolysaccharide per 100 grams dry weight of the composition,
wherein the composition is in the form of a liquid and does not comprise human milk.
6. The method according to claim 1 , wherein the composition consists of:
(a) 0.5-10 grams transgalactooligosaccharide per 100 grams dry weight of the composition,
(b) 0.5-10 grams fructopolysaccharide per 100 grams dry weight of the composition,
(c) a fructan, fructooligosaccharide, a hydrolysed inulin or an inulin, and
(d) optionally, a long chain polyunsaturated fatty acid (LC-PUFA),
wherein, as a percentage of the total caloric value of the composition, (i) 35-50% energy is derived from fat; (ii) 7.5-12.5% energy is derived from protein; and 40-55% energy is derived from carbohydrate; and
wherein the composition is in the form of a liquid and does not comprise human milk.
7. The method according to claim 1 , wherein at least 50%, by weight, of the carbohydrate of the composition is lactose.
8. The method according to claim 1 , wherein the LC-PUFA is selected from the group consisting of eicosapentaenoic acid (EPA, n-3), docosahexaenoic acid (DHA, n-3) and arachidonic acid (AA, n-6).
9. A method of reducing the incidence of upper respiratory tract infection episodes comprising administering to an infant mammal in need thereof a liquid infant formula composition consisting of:
(a) 0.5-10 grams transgalactooligosaccharide per 100 grams dry weight of the composition,
(b) 0.5-10 grams fructopolysaccharide per 100 grams dry weight of the composition,
(c) optionally, indigestible dextrins, xylooligosaccharides, arabinooligosaccharides, glucooligosaccharides, mannooligosaccharides, fucooligosaccharides, fructans, fructooligosaccharide, hydrolysed inulin or inulin, and
(d) optionally, a long chain polyunsaturated fatty acid (LC-PUFA),
wherein the composition is in the form of a liquid and does not comprise human milk.