Diazo bicyclic Smac mimetics and the uses thereof

1. A compound selected from the group consisting of:

or a pharmaceutically acceptable salt thereof.

2. A compound selected from the group consisting of:

or the free base thereof or another pharmaceutically acceptable salt thereof.

3. A compound of formula:

or a pharmaceutically acceptable salt thereof.

4. A pharmaceutical composition comprising the compound of claim 3 , or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

5. A process for preparing a compound of Formula XI

wherein

A 1 and A 2 are independently selected from the group consisting of hydrogen and optionally substituted alkyl;

V is selected from the group consisting of N;

W is selected from the group consisting of CH;

X is selected from the group consisting of hydrogen and optionally substituted C 1-3 alkyl;

Y is NHCO where NH is connected to the ring and CO is connected to W;

T is C═O;

U is NR 1 R 2 ;

Z is (CR 1 R 2 ) r , wherein r is 0;

m is 1;

each of R 1 and R 2 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted carbocyclic, optionally substituted heterocyclic, optionally substituted aryl and optionally substituted heteroaryl; and

R 7 is selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted carbocyclic, optionally substituted heterocyclic, optionally substituted aryl and optionally substituted heteroaryl;

comprising condensing a compound of Formula XII

wherein A 1 , A 2 , V, W, X, Y, T, U and m have the meanings described above for Formula XI;

with R 7 CO-L, and

L is a leaving group, to form a compound of Formula XI.