FTY720-derived anticancer agents
View Patent ↗A number of FTY720-derived compounds with antitumor activity are described. These compounds include the compounds of formula I: wherein R 1 is independently selected from the group consisting of hydrogen, methyl. methoxy, and hydroxyl; R 2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl; R 3 is independently selected from the group consisting of alkyl and cyclo-alkyl; and n is independently selected from 0 to 6. The compounds have lower immunosuppressive side effects as a result of not being phosphorylated by sphingosine kinase 2.
1. A compound of formula I:
wherein R 1 is independently selected from the group consisting of hydrogen, methyl. methoxy, and hydroxyl;
R 2 is independently selected from the group consisting of hydrogen, methoxy, and hydroxyl;
R 3 is independently selected from the group consisting of alkyl and cyclo-alkyl; and
n is independently selected from 0 to 6.
2. The compound of claim 1 , wherein R 1 is hydrogen.
3. The compound of claim 2 , wherein n is from 0 to 3.
4. The compound of claim 1 , wherein R 1 is methyl.
5. The compound of claim 4 , wherein n is from 0 to 3.
6. The compound of claim 1 , wherein R 2 is hydrogen.
7. The compound of claim 1 , wherein R 2 is 2-methoxy.
8. The compound of claim 1 , wherein R 2 is 3-methoxy.
9. The compound of claim 1 , wherein R 2 is 2-hydroxy.
10. The compound of claim 1 , wherein R 2 is 3-hydroxy.
11. The compound of claim 1 , wherein R 3 is propyl.
12. The compound of claim 1 , wherein R 3 is isopropyl.
13. The compound of claim 1 , wherein R 3 is isobutyl.
14. The compound of claim 1 , wherein R 3 is cyclopropyl methyl.
15. The compound of claim 1 , wherein R 3 is cyclobutyl methyl.
16. The compound of claim 1 , wherein the compound has the structure: