Biological adhesive
Biologically compatible polymers carry at least two different kinds of functional groups. Adhesive formulations include a biologically compatible adhesive, which can be used with a bridging molecule.
1. A composition comprising a biologically compatible polymer functionalized with at least two species of reactive moiety, wherein one reactive moiety binds to a biological surface, and one of said reactive moieties is methacrylate or aldehyde.
2. The composition according to claim 1 , wherein said polymer comprises at least ten monomeric units.
3. A composition comprising a biologically compatible polymer functionalized with at least two species of reactive moiety, wherein said polymer is functionalized through one or more thio, carboxylic acid or alcohol moieties.
4. A composition comprising the composition of claim 1 and a biological surface.
5. The composition of claim 4 , wherein said biological surface is on a cell, tissue or organ.
6. The composition of claim 5 , wherein said tissue is ocular tissue.
7. The composition of claim 5 , wherein said tissue comprises an intervertebral disc.
8. A composition comprising the composition of claim 1 and a hydrogel functionalized with a reactive moiety.
9. The composition of claim 8 , wherein said hydrogel comprises poly(ethylene oxide) diacrylate.
10. The composition of claim 8 , wherein said hydrogel further comprises a biocompatible polymer.
11. The composition of claim 10 , wherein said biocompatible polymer is hyaluronic acid.
12. The composition of claim 8 , wherein said hydrogel comprises a biologically active agent.
13. A composition comprising the composition of claim 1 and a polyfunctional bridging molecule reactive therewith.
14. The composition of claim 13 , wherein said bridging molecule reacts with said reactive moiety which reacts with a biological surface.
15. The composition of claim 13 , wherein said biologically compatible polymer comprises a second reactive moiety, wherein said bridging molecule reacts with said second reactive moiety.
16. The composition of claim 13 , wherein said polyfunctional bridging molecule comprises multiple amine groups.
17. A composition comprising the composition of claim 13 and a biological surface.
18. The composition of claim 17 , wherein said biological surface is on a cell, tissue or organ.
19. The composition of claim 18 , wherein said tissue is ocular tissue.
20. A composition comprising the composition of claim 1 and a support.
21. The composition of claim 20 , wherein said support is an inert carrier.
22. The composition of claim 13 , wherein said polymer comprises a film and said bridging molecule comprises a film, wherein said films are stacked on each other.
23. The composition of claim 22 , comprising a third film comprising a biologically compatible polymer, stacked onto said film comprising said bridging molecule.
24. The composition of 23 , further comprising a support.
25. The composition of claim 24 , wherein said support is an inert carrier.
26. A composition comprising the composition of claim 20 and a biological surface.
27. The composition of claim 26 , wherein said biological surface is on a cell, tissue or organ.
28. The composition of claim 27 , wherein said tissue is ocular tissue.
29. A composition comprising the composition of claim 13 and a support.
30. The composition of claim 29 , wherein said support is an inert carrier.