Method for diagnosing and/or treating tumor
An object of the present invention is to provide methods for diagnosing and/or treating tumors using HERV-H env gene or HERV-H env Env protein. Specifically, tumors are diagnosed by detecting expression of HERV-H env gene; and agents for detecting the expression are used as diagnosing agents. Further, tumors are treated by inhibiting function of HERV-H env gene; and agents for inhibiting the function are used as antitumor agents. Furthermore, tumors are treated by administering a peptide having a certain sequence of HERV-H Env protein and the like; and the peptide is used as a cancer vaccine.
1. An isolated peptide consisting of any one of SEQ ID NOs: 3 to 5.
2. An isolated antigen-presenting cell presenting a peptide according to claim 1 on the cell surface.
3. A composition comprising a peptide according to claim 1 , or an expression vector expressing a peptide according to claim 1 .
4. A composition comprising a peptide of claim 1 and a tumor antigen peptide other than the peptide.
5. A composition comprising the isolated antigen-presenting cell according to claim 2 .