Soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall

1. A soft tissue prosthesis for repairing a defect of an abdominal wall or a pelvic cavity wall, comprising:

a three-dimensional mesh sheet constructed and arranged to repair a defect of an abdominal wall or a pelvic cavity wall comprising at least two different yarns interlooped or intertwined to define at least two layers, wherein one of the at least two layers is substantially non-biodegradable and porous to allow for tissue ingrowth and another of the at least two layers is substantially biodegradable; and

an adhesion barrier in the form of a film, foam or gel, the adhesion barrier polymerized to, and entrapping therein, at least some of the yarns of the substantially biodegradable layer, the substantially biodegradable layer making a connection between the adhesion barrier and the substantially non-biodegradable layer to decrease the likelihood of delamination therefrom, the adhesion barrier being an external layer on a first side of the prosthesis and the substantially non-biodegradable layer being an external layer on the side of the prosthesis opposite the first side, the substantially biodegradable layer being positioned between the substantially non-biodegradable layer and the adhesion barrier.

2. The soft tissue prosthesis of claim 1 , wherein the one of the at least two different yarns is non-biodegradable yarn.

3. The soft tissue prosthesis of claim 2 , wherein the non-biodegradable yarn is selected from polypropylene, polyethylene terephthalate or a combination thereof.

4. The soft tissue prosthesis of claim 2 , wherein the non-biodegradable yarn has a diameter of about 0.005 inches.

5. The soft tissue prosthesis of claim 1 , wherein one of the at least two different yarns is biodegradable yarn.

6. The soft tissue prosthesis of claim 5 , wherein the biodegradable yarn is selected from poly (glycolic) acid, polylactic acid, polydioxanone, polycaprolactone, calcium alginate or a combination thereof.

7. The soft tissue prosthesis of claim 5 , wherein the biodegradable yarn has a diameter no greater than about 90 denier.

8. The soft tissue prosthesis of claim 1 , wherein the three-dimensional mesh includes at least one non-biodegradable monofilament yarn and at least one biodegradable multifilament yarn.

9. The soft tissue prosthesis of claim 1 , wherein the adhesion barrier comprises a crosslinked polymer hydrogel.

10. The soft tissue prosthesis of claim 1 , wherein the adhesion barrier comprises at least one polyanionic polysaccharide modified by reaction with carbodiimide.

11. The soft tissue prosthesis of claim 1 , wherein the adhesion barrier comprises a crosslinked polymer hydrogel and at least one polyanionic polysaccharide modified by reaction with carbodiimide.

12. The soft tissue prosthesis of claim 11 , wherein the crosslinked polymer hydrogel comprises one or more hydrophilic blocks, one or more biodegradable blocks, and one or more crosslinking blocks.

13. The soft tissue prosthesis of claim 11 , wherein the crosslinked polymer hydrogel is formed by photopolymerization of monomers comprising photopolymerizable poly(ethylene glycol)-trimethylene carbonate/lactate multi-block polymer endcapped with acrylate esters.

14. The soft tissue prosthesis of claim 11 , wherein the at least one polyanionic polysaccharide modified by reaction with carbodiimide comprises carbodiimide-modified hyaluronic acid and carbodiimide-modified carboxymethylcellulose.

15. The soft tissue prosthesis of claim 1 , wherein the adhesion barrier is in the form of a film or foam.

16. The soft tissue prosthesis of claim 1 , wherein the adhesion barrier is in the form of a gel.

17. The soft tissue prosthesis of claim 1 , wherein the surgical prosthesis has moisture content of less than about 2%.

18. The soft tissue prosthesis of claim 1 , wherein the surgical prosthesis has moisture content of less than about 1.2%.

19. The soft tissue prosthesis of claim 1 , wherein the adhesion barrier has a density of about 5 grams total polymer per square foot.

20. The soft tissue prosthesis of claim 1 , wherein the substantially non-biodegradable layer has an external surface comprising a macroporous structure.

21. The soft tissue prosthesis of claim 20 , wherein the macroporous structure has a pore size of about 100 microns or more.

22. The soft tissue prosthesis of claim 20 , wherein the substantially non-biodegradable layer comprises a yarn selected from polypropylene, polyethylene terephthalate or a combination thereof.

23. The soft tissue prosthesis of claim 20 , wherein the substantially biodegradable layer comprises a yarn selected from poly(glycolic) acid, polylactic acid, polydioxanone, polycaprolactone, calcium alginate or a combination thereof.

24. The soft tissue prosthesis of claim 20 , wherein the barrier comprises a crosslinked polymer hydrogel and at least one polyanionic polysaccharide modified by reaction with carbodiimide.

25. The soft tissue prosthesis of claim 24 , wherein the crosslinked polymer hydrogel comprises one or more hydrophilic blocks, one or more biodegradable blocks, and one or more crosslinking blocks.

26. The soft tissue prosthesis of claim 24 , wherein the crosslinked polymer hydrogel is formed by polymerization of monomers comprising photopolymerizable poly(ethylene glycol)-trimethlyene carbonate/lactate multi-block polymers endcapped with acrylate esters.

27. The soft tissue prosthesis of claim 24 , wherein the at least one polyanionic polysaccharide modified by reaction with carbodiimide comprises carbodiimide-modified hyaluronic acid and carbodiimide-modified carboxymethylcellulose.

28. The soft tissue prosthesis of claim 1 in which the mesh has a macroporous structure.