Recombinant proteins of parapoxvirus ovis and pharmaceutical compositions therefrom
The invention relates to polynucleotides coding for the PPVO viral genome, to fragments of the polynucleotides coding for the PPVO genome and to polynucleotides coding for individual open reading frames (ORFs) of the PPVO viral genome. The invention also relates to recombinant proteins expressed from the above mentioned polynucleotides and to fragments of said recombinant proteins, and to the use of said recombinant proteins or fragments for the preparation of pharmaceutical compositions.
1. A method for inducing an immunomodulatory activity in a subject, consisting of administering to the subject an individual recombinant protein encoded by a polynucleotide consisting of nucleotide residues 102490 to 108393 of SEQ ID NO:1 (PPVO insert of VVOV 330).
2. The method of claim 1 , wherein the immunomodulatory activity results in the induction of interferon-gamma.
3. The method of claim 1 , wherein the immunomodulatory activity results in the induction of tumor necrosis factor-alpha.
4. The method of claim 1 , wherein the immunomodulatory activity results in the stimulation of MHC-I cross-presentation.