IP Library › Granted Patent US 8,361,966
Granted Patent B2
US 8,361,966 · App. 12/312,077 · Granted Jan 29, 2013

Use of interleukin-11 as therapeutic agent for heart disease

Inventors: Junichi Azuma (Suita, JP); Yasushi Fujio (Suita, JP); Ryusuke Kimura (Suita, JP); Makiko Maeda (Suita, JP); Atsushi Arita (Suita, JP); Masanori Obana (Suita, JP); Takashi Ito (Suita, JP); Tsuyoshi Fukuda (Suita, JP)
Assignee: Osaka University
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Quick Facts
Patent No.
US 8,361,966
App. No.
12/312,077
Granted
Jan 29, 2013
Kind
B2
Abstract

The present invention demonstrates the myocardial protective effects of interleukin 11 in vivo, and provides preventive, therapeutic, or other types of drugs for heart disease using interleukin 11 as the active ingredient. The present invention, by utilizing the myocardial protective effects of interleukin 11, can suppress the progress of myocardial injury, prevent the onset of heart failure, or suppress the progress of heart failure.

Claims (3)

1. A method of treating heart disease, consisting of administering an effective amount of interleukin 11 (IL-11) and a carrier or vehicle to a patient in need thereof, wherein the heart disease is selected from the group consisting of myocardial remodeling after a myocardial injury and myocardial infarction, wherein the administration of the IL-11 regenerates myocardial tissue.

2. The method according to claim 1 , wherein the heart disease is myocardial remodeling after a myocardial injury.

3. The method according to claim 1 , wherein the heart disease is myocardial infarction.

Assignments (4)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 5, 2012
From: NEW INDUSTRY RESEARCH ORGANIZATION, THE
To: OSAKA UNIVERSITY
Reel/Frame 029238/0058 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2009
From: KIMURA, RYUSUKE
To: NEW INDUSTRY RESEARCH ORGANIZATION; OSAKA UNIVERSITY
Reel/Frame 022702/0066 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2009
From: FUKUDA, TSUYOSHI
To: NEW INDUSTRY RESEARCH ORGANIZATION, THE; OSAKA UNIVERSITY
Reel/Frame 022705/0518 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 14, 2009
From: AZUMA, JUNICHI; FUJIO, YASUSHI; MAEDA, MAKIKO; ARITA, ATSUSHI; OBANA, MASANORI; ITO, TAKASHI
To: NEW INDUSTRY RESEARCH ORGANIZATION, THE; OSAKA UNIVERSITY
Reel/Frame 022705/0521 →
Priority Claims (1)
JP 2006-293062 · Oct 27, 2006 · national
Continuity (1)
Related Publication 20100093976A1 · Apr 15, 2010