Ostium support for treating vascular bifurcations

1. A prosthesis for placement at an ostium opening from a main body lumen to a branch body lumen, the prosthesis comprising:

a radially expansible support having a plurality of proximal apices, the support configured to be deployed in at least a portion of a body lumen adjacent the ostium opening;

a transition portion coupled with at least one of the proximal apices on the support and having a distal section with four side-by-side filaments and a proximal section having two side-by-side filaments;

a plurality of elongate members extending axially and proximal of the transition portion, the elongate members configured to be deformably deployed in at least a portion of a body lumen adjacent the ostium; and

a circumferential member connected to at least one of the elongate members;

wherein the elongate members comprise a zone having a single filament, the single filament having a proximal end coupled with the circumferential member and a distal end disposed between the proximal end and the transition portion.

2. The prosthesis of claim 1 , wherein the support comprises a closed cell structure.

3. The prosthesis of claim 2 , wherein each of the cells comprise lateral members adapted to enhance the flexibility of the support by permitting localized axial expansion or compression within the support.

4. The prosthesis of claim 2 , wherein each of the cells comprises N-shaped connector disposed on opposite lateral sides of the cells.

5. The prosthesis of claim 1 , wherein the support comprises an open cell structure.

6. The prosthesis of claim 5 , wherein the support comprises a first circumferentially oriented undulating member and a second circumferentially oriented undulating member, the second circumferentially oriented undulating member disposed proximally of the first circumferentially oriented undulating member, the support further comprising a plurality of longitudinal interconnecting members extending from distal apices of the second circumferentially oriented undulating member to distal spices of the first circumferentially oriented undulating member.

7. The prosthesis of claim 6 , wherein the longitudinal interconnecting members comprise at least one circumferentially oriented undulation.

8. The prosthesis of claim 5 , wherein the support comprises a plurality of circumferential bands, the circumferential bands being coupled at alternating undulating positions.

9. The prosthesis of claim 8 , further comprising a linking member linking proximal apices of a first circumferential bands and distal spices of a second circumferential band, the second circumferential band being located adjacent and proximal to the first circumferential band.

10. The prosthesis of claim 9 , wherein two unconnected apices are disposed circumferentially between adjacent linking members.

11. The prosthesis of claim 1 , wherein at least one elongate member comprises a dual serpentine section.

12. The prosthesis of claim 11 , wherein the dual serpentine section is configured for transitioning from a bifurcation with a high take-off angle.

13. The prosthesis of claim 11 , wherein the dual serpentine section is configured for transitioning from a bifurcation with a low take-off angle.

14. The prosthesis of claim 11 , wherein the dual serpentine extends over a length that is less than ⅓ the length of the single filament of the elongate members.

15. The prosthesis of claim 11 , wherein the dual serpentine section extends over a length that is ½ or more than the length of the single filament of the frond sections elongate members.

16. A prosthesis for placement at an ostium opening at a vascular bifurcation, the prosthesis comprising:

a radially expansible support having a density of struts and having a plurality of apices disposed at an end of the support, the support extending along a longitudinal axis and configured to be deployed in a vascular segment adjacent to a bifurcation;

at least one elongate member extending axially from an end of the support, the elongate member including a first end with a transition portion coupled to apices on the support and a second end, the elongate member comprising a section with a single filament extending between the transition portion to the second end of the elongate members, the single filament having a distal end, a proximal end, and a longitudinal axis extending between the distal and proximal ends, the longitudinal axis of the single filament and the longitudinal axis of the radially expansible support being substantially parallel at least in an unexpanded state, wherein at least a portion of the transition portion has at greater density of struts than the density of struts of the support at least in the unexpanded state;

the elongate member being configured to be deployed in a vascular segment adjacent to a bifurcation; and

a circumferential member connected to the single filament at the second end of the elongate member.

17. The prosthesis of claim 16 , wherein at least one of the support and the elongate members comprises drug containing portions disposed thereon.

18. A prosthesis for placement across an ostium at a vascular bifurcation, the prosthesis comprising:

a radially expansible support having a first end, a second, and length therebetween defined along a longitudinal axis, the support configured to be deployed in and provide scaffolding in a vascular segment adjacent to the ostium by a first amount of material per unit area of support members;

at least one elongate member extending from one of the first or second ends of the support, the elongate member having a first end with a transition portion and a second end, the transition portion coupled to one of the first or second ends of support, the transition portion having a plurality of support members with a second amount of material per unit area different from the first amount of material per unit area of support members at least in an unexpanded state, the elongate member comprising a section having a single filament extending between the transition portion and the second end of the elongate member, the single filament undulating about an axis that extends substantially parallel to a projection of the longitudinal axis of the support at least in the unexpanded state;

the elongate member configured to be deployed within a vascular segment adjacent to the ostium; and

a circumferential member connected to the single filament of the at least one elongate member at the second end of the elongate member;

wherein at least one of the radially expansible support and the elongate member comprise drug containing portions disposed thereon.

19. The prosthesis of claim 18 , wherein the transition portion comprises depots configured to retain a drug.

20. The prosthesis of claim 18 , wherein the single filament comprises a serpentine portion.

21. The prosthesis of claim 18 , wherein the transition portion comprises first and second straight members joined at one end and coupled at the opposite end with different apices of the support.