Estrogen receptor ligands

1. A compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt,

wherein R 1 is selected from the group consisting of halogen, cyano, nitro, OR A , N(R B ) 2 , —C(O)C 1-4 alkyl, —SO 2 C 1-4 alkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl, trihaloC 1-6 alkyl, cyanoC 1-6 alkyl, C 1-4 alkoxyC 1-6 alkyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, phenyl, benzyl, and 5-10 membered heterocyclyl, wherein said phenyl, benzyl or heterocyclyl group can be either unsubstituted or substituted with from 1 to 3 substituents, each substituent being selected from the group consisting of OR A , halogen, cyano, nitro, —C(O)C 1-4 alkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl and trihaloC 1-6 alkyl;

R 2 is selected from the group consisting of halogen, cyano, nitro, OR A , N(R B ) 2 , —C(O)C 1-4 alkyl, —SO 2 C 1-4 alkyl, —C(O)NH—OH, —C(NH 2 )═N—OH, —C(NH 2 )═NH, —NH—C(NH 2 )═NH, —NH—C(O)NH 2 , —N═C(—NH—CH 2 CH 2 —NH—), —S—C(NH 2 )═NH, —CO 2 H, —CH 2 —CO 2 H, SO 3 H, CH 2 SO 3 H, C 1-6 alkyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl, trihaloC 1-6 alkyl, cyanoC 1-6 alkyl, C 1-4 alkoxyC 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, phenyl, benzyl and 5-10 membered heterocyclyl wherein said phenyl, benzyl or heterocyclyl group can be either unsubstituted or substituted with from 1 to 3 substituents each substituent being selected from the group consisting of OR A , halogen, cyano, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl and trihaloC 1-6 alkyl; provided that if one of R 1 and R 2 represents halogen, the other must represent a group other than halogen;

each of R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of hydrogen, OR A , halogen, cyano, nitro, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-6 alkyl, dihaloC 1-6 alkyl and trihaloC 1-6 alkyl;

each R A is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, C 6-10 aryl and C 6-10 arylC 1-6 alkyl, each optionally substituted by from 1 to 3 halogen atoms; and

each R B is independently selected from the group consisting of hydrogen, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, C 3-8 cycloalkyl, C 3-8 cycloalkylC 1-6 alkyl, C 6-10 aryl and C 6-10 arylC 1-6 alkyl, each optionally substituted by from 1 to 3 halogen atoms;

with the proviso that the compound of formula (I) is not 4-[3-(4,5-Dihydro-1H-imidazol-2-yl)-2-(3,5-dimethyl-isoxazol-4-yl)-indol-1-yl]-phenol;

1-(4-Hydroxy-phenyl)-2-(4-methyl-imidazol-1-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(1H-pyrazol-3-yl)-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-prop-1-ynyl-1H-indole-3-carboxylic acid amide; or

1-(4-Hydroxy-phenyl)-2-thiazol-2-yl-1H-indole-3-carboxylic acid.

2. A compound as claimed in claim 1 , in which each R A is independently selected from the group consisting of hydrogen, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 3-6 cycloalkyl, phenyl and benzyl.

3. A compound as claimed in claim 2 , in which each R A independently represents hydrogen or C 1-4 alkyl.

4. A compound as claimed in claim 1 , in which each R B is independently selected from the group consisting of hydrogen and C 1-4 alkyl.

5. A compound as claimed in claim 1 , in which R 1 is selected from the group consisting of OR A , N(R B ) 2 , —C(O)C 1-4 alkyl, C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-4 alkyl, dihaloC 1-4 alkyl, trihaloC 1-4 alkyl, phenyl, and 5-6 membered heterocyclyl, wherein said phenyl or heterocyclyl group can either be unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of OR A , halogen, cyano, —C(O)C 1-4 alkyl, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, haloC 1-4 alkyl, dihaloC 1-4 alkyl and trihaloC 1-4 alkyl.

6. A compound as claimed in claim 5 , in which R 1 is selected from the group consisting of OR A , N(R B ) 2 , —C(O)C 1-4 alkyl, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, phenyl, and 5-6 membered heterocyclyl, wherein said phenyl or heterocyclyl group can either be unsubstituted or substituted by 1 to 3 substituents selected from halogen, cyano, C 1-4 alkyl, —C(O)C 1-4 alkyl, and OR A in which R A represent hydrogen or C 1-4 alkyl.

7. A compound as claimed in claim 1 , in which R 2 is selected from the group consisting of halogen, OR A , N(R B ) 2 , —C(O)C 1-4 alkyl C 1-6 alkyl, C 2-6 alkenyl, C 2-6 alkynyl, haloC 1-4 alkyl, dihaloC 1-4 alkyl, trihaloC 1-4 alkyl, phenyl, and 5-6 membered heterocyclyl, wherein said phenyl or heterocyclyl group can either be unsubstituted or substituted by 1 to 3 substituents selected from the group consisting of OR A , halogen, cyano, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, haloC 1-4 alkyl, dihaloC 1-4 alkyl and trihaloC 1-4 alkyl.

8. A compound as claimed in claim 7 , in which R 2 is selected from the group consisting of —C(O)C 1-4 alkyl, —CO 2 H, —CH 2 —CO 2 H, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, and 5-6 membered heterocyclyl wherein said heterocyclyl group can either be unsubstituted or substituted by 1 to 3 substituents selected from halogen, cyano, C 1-4 alkyl, and OR A .

9. A compound as claimed in claim 1 , in which each of R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of hydrogen, OR A , halogen, cyano, C 1-4 alkyl, haloC 1-4 alkyl, dihaloC 1-4 alkyl, and trihaloC 1-4 alkyl.

10. A compound as claimed in claim 9 , in which each of R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of hydrogen, OH, halogen, cyano, methyl, or trifluoromethyl.

11. A compound as claimed in claim 1 , in which R 1 is a 5-6 membered heterocyclyl group, wherein said heterocyclyl group is substituted with from 1 to 3 substituents selected from halogen, cyano and C 1-4 alkyl;

R 2 is selected from the group consisting of —C(O)CH 3 , —C(NH 2 )═N—OH, —CO 2 H, and —CH 2 —CO 2 H; and

each of R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of hydrogen and halogen.

12. A compound as claimed in claim 11 , in which R 1 is a 5-membered heterocyclyl group, wherein said heterocyclyl group is substituted with two substituents independently selected from methyl and ethyl;

R 2 is —C(NH 2 )═N—OH; and

each of R 3 , R 4 , R 5 and R 6 is independently selected from the group consisting of hydrogen and halogen.

13. A compound selected from the group consisting of:

2-Bromo-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-thiophen-3-yl-1H-indole-3-carbonitrile;

2-(3-Cyano-furan-2-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carbonitrile;

2-Dimethylamino-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-isopropyl-1H-indole-3-carbonitrile;

2-Acetyl-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carboxylic acid;

1-[1-(4-Hydroxy-phenyl)-2-phenyl-1H-indol-3-yl]-ethanone;

1-(4-Hydroxy-phenyl)-2-phenyl-1H-indole-3-carboxylic acid, amide;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

[2-(3,5-Dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indol-3-yl]-carbamic acid tert-butyl ester;

4-[3-Amino-2-(3,5-dimethyl-isoxazol-4-yl)-indol-1-yl]-phenol;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-7-fluoro-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-2-(5-chlorothiophen-2-yl)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(3,5-dimethyl-isoxazol-4-yl)-1H-indole-3-carbonitrile;

2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indole-3-carbohydrazonamide;

4-(2-(3,5-dimethylisoxazol-4-yl)-3-(1,2,4-oxadiazol-3-yl)-1H-indol-1-yl)phenol;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carboxylic acid, methyl ester;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carboxylic acid, hydroxyamide;

4-[2-(3,5-Dimethyl-isoxazol-4-yl)-3-methanesulfonyl-indol-1-yl]-phenol;

1-[2-(3,5-Dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indol-3-yl]-2,2,2-trifluoro-ethanone;

4-(3-bromo-2-(3,5-dimethylisoxazol-4-yl)-1H-indol-1-yl)phenol;

2-Bromo-5-fluoro-1-(4-hydroxy-phenyl)-1H-indol-3-carbonitrile;

(Z)-2-(4-fluorophenoxy)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indol-3-carboximidamide;

4-(2-(3,5-dimethylisoxazol-4-yl)-3-nitro-1H-indol-1-yl)phenol;

4-(3-(dihydroxyamino)-2-(3,5-dimethylisoxazol-4-yl)-1H-indol-1-yl)phenol;

N-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)acetamide

N-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)methanesulfonamide;

1-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)urea;

4-(2-(3,5-dimethylisoxazol-4-yl)-3-thiocyanato -1H-indol-1-yl)phenol;

(E)-2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl N′-hydroxycarbamimidothioate;

4-(3-benzyl-2-phenyl-1H-indol-1-yl)phenol;

2-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)-2-oxoacetamide;

(Z)-2-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)-2-(hydroxyimino)acetamide;

2-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)-2-hydroxyacetamide;

2-(2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)acetamide;

2-((Z)-But-1-enyl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(2-methyl-allyl)-1H- indole-3-carbonitrile;

(Z)-2-(5-ethyl-3-methylisoxazo1-4-yl)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

4-(2-(3,5-dimethylisoxazol-4-yl)-3-phenyl-1H-indol-1-yl)phenol;

4-(3-chloro-2-(3,5-dimethylisoxazol-4-yl)-1H-indol-1-yl)phenol;

2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indole-3-sulfonamide;

2-(3,5-dimethylisoxazol-4-yl)-1-(2-fluoro-4-hydroxyphenyl)-1H-indole-3-carboximidamide;

1-(4-Hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-methyl-1H-indole-3-carbonitrile;

2-(3-Cyano-thiophen-2-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-((E)-propenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-thiophen-2-yl-1H-indole-3-carbonitrile;

2-(3,5-dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-pyridin-4-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(1-methyl-1H-pyrrol-2-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(3-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-isopropylamino-1H-indole-3-carbonitrile;

2-Ethylamino-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Butylamino-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-piperidin-1-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-pyrrolidin-1-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-morpholin-4-yl-1H-indole-3-carbonitrile;

2-Diethylamino-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Ethynyl-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-vinyl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-1H-indole-2,3-dicarbonitrile;

1-(4-Hydroxy-phenyl)-2-prop-1-ynyl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-pyridin-2-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(2-methyl-allyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-((Z)-propenyl)-1H-indole-3-carbonitrile;

2-(Butyl-methyl-amino)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-((Z)-1-methyl-propenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-imidazol-1-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-[1 ,2,4]triazol-1-yl-1H-indole-3-carbonitrile;

2-(3,5-dimethyl-pyrazol-1-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-pyrazol-1-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(5-methyl-imidazol-1-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(5-methyl-pyrazol-1-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(3-methyl-pyrazol-1-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-thiazol-2-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(2-methoxy-thiazol-4-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-thiazol-4-yl-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(3-methyl-but-2-enyl)-1H-indole-3-carbonitrile;

2-((E)-But-1-enyl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(5-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

2-(5-Acetyl-thiophen-2-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

2-(5-Chloro-thiophen-2-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(4-methyl-thiophen-3-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(4-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

2-(4-Cyano-thiophen-3-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(2-methyl-2H-pyrazol-3-yl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

2-(2-Acetyl-pyrro 1-1-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(2-Ethyl-pyrrol-1-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(2-Cyano-pyrrol-1-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(4-Hydroxy-phenyl)-2-(2-methyl-pyrrol-1-yl)-1H-indole-3-carbonitrile;

1-(3-Chloro-5-fluoro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(3-Chloro-5-fluoro-4-hydroxy-phenyl)-2-(3-cyano-thiophen-2-yl)-1H-indole-3-carbonitrile;

1-(3-Chloro-5-fluoro-4-hydroxy-phenyl)-2-(3-cyano-furan-2-yl)-1H-indole-3-carbonitrile;

2-Bromo-1-(3-chloro-5-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Bromo-1-(2-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(2-Fluoro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

2-Bromo-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Bromo-1-(2,3-difluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Bromo-1-(2,5-difluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Bromo-1-(3-chloro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Bromo-1-(3,5-difluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(2,5-Difluoro-4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-thiophen-3-yl-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-thiophen-2-yl-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-(3,5-dimethyl-isoxazol-4-yl)-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrrol-2-yl)-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-(3-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

1-(3,5-Difluoro-4-hydroxy-phenyl)-2-pyridin-4-yl-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-thiophen-3-yl-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-thiophen-2-yl-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-(3,5-dimethyl-isoxazol-4-yl)-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2(1-methyl-1H-pyrrol-2-yl)-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-(3-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

1-(3-Chloro-4-hydroxy-phenyl)-2-pyridin-4-yl-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-thiophen-3-yl-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-thiophen-2-yl-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrrol-2-yl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(3-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-pyridin-4-yl-1H-indole-3-carbonitrile;

2-Dimethylamino-1-(2- fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(2-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-((E)-propenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-((Z)-propenyl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-((Z)-propenyl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-vinyl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-thiophen-3-yl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-thiophen-2-yl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(3-methyl-thiophen-2-yl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrrol-2-yl)-1H-indole-3-carbonitrile;

2-(2-Acetyl-pyrrol-1-yl)-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-prop-1-ynyl-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carbonitrile;

2-(2-Acetyl-pyrrol-1-yl)-1-(2,3-difluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-pyrazol-1-yl-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-pyrazol-1-yl-1H-indole-3-carbonitrile;

2-(2,5-Dimethyl-pyrrol-1-yl)-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(2-Ethyl-pyrrol-1-yl)-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(2-Cyano-pyrrol-1-yl)-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(2-methyl-pyrrol-1-yl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(2-ethyl-pyrrol-1-yl)-1H-indole-3-carbonitrile;

2-(2-Cyano-pyrrol-1-yl)-1-(2,3-difluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(2-methyl-pyrrol-1-yl)-1H-indole-3-carbonitrile;

1-(2-Fluoro-4-hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carbonitrile;

1-(2,3-difluoro-4-hydroxyphenyl)-2-(3-methylbut-2-enyl)-1H-indole-3-carbonitrile;

[1-(4-Hydroxy-phenyl)-2-phenyl-1H-indol-3-yl]-acetonitrile;

[1-(4-Hydroxy-phenyl)-2-phenyl-1H-indol-3-yl]-acetic acid;

2-[1-(4-Hydroxy-phenyl)-2-phenyl-1H-indol-3-yl] -acetamide;

4-(3-Isopropenyl-2-phenyl-indol-1-yl)-phenol;

4-[3-(2-Methyl-2H-pyrazol-3-yl)-2-phenyl-indol-1-yl]-phenol;

4-(2-Phenyl-3-thiazol-4-yl-indol-1-yl)-phenol;

4-(2-Phenyl-3-prop-1-ynyl-indol-1-yl)-phenol;

1-(4-Hydroxy-phenyl)-2-((E)-propenyl)-1H-indole-3-carboxylic acid, amide;

1-(4-Hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carboxylic acid, amide;

1-(4-Hydroxy-phenyl)-2-((Z)-1-methyl-propenyl)-1H-indole-3-carboxylic acid, amide;

4-(2-Phenyl-3-pyrazol-1-yl-indol-1-yl)-phenol;

4-(3-Imidazol-1-yl-2-phenyl-indol-1-yl)-phenol;

4-[3-(5-Methyl-pyrazol-1-yl)-2-phenyl-indol-1-yl]-phenol;

2-Bromo-1-(4-hydroxy-phenyl)-1H-indole-3-carboxylic acid, amide;

1-(4-Hydroxy-phenyl)-2-((Z)-3,3,3-trifluoro-propenyl)-1H-indole-3-carbonitrile;

(Z)-2-bromo-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2)-(1H-pyrrol-1-yl)-1H-indole-3-carboximidamide;

2-(3,5-dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carboxylic acid, amide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2-(2-methylprop-1-enyl)-1H-indole-3-carboximidamide;

1-(4-Hydroxy-phenyl)-2-phenyl-1H-indole-3-carboxylic acid; hydroxyamide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2-phenyl-1H-indole-3-carboximidamide;

1-(4-Hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carboxylic acid, amide;

[1-(4-Hydroxy-phenyl)-2-pyrrol-1-yl-1H-indol-3-yl]-carbamic acid tert-butyl ester;

2-(3,5-dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-N-methyl-1H-indole-3-carboxamidine;

Methyl 2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indole-3-carbimidate;

N-((2-(3,5-dimethylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indol-3-yl)(imino)methyl)acetamide;

2-(5-ethyl-3-methylisoxazol-4-yl)-1-(4-hydroxyphenyl)-1H-indole-3-carboxamide;

(Z)-2-(2-ethyl-1H-pyrrol-1-yl)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2-(2-methyl-1H-pyrrol-1-yl)-1H-indole-3-carboximidamide;

1-(4-hydroxyphenyl)-2-(2-methyl-1H-pyrrol-1-yl)-1H-indole-3-carboxamide;

4-(3-chloro-2-(3,5-dimethylisoxazol-4-yl)-1H-indol-1-yl)phenol;

(Z)-2-((Z)-but-2-en-2-yl)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2-(5-methyl-1H-pyrazol-1-yl)-1H-indole-3-carboximidamide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2-(4-methylthiophen-3-yl)-1H-indole-3-carboximidamide;

(Z)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-N′-hydroxy-1-(4-hydroxyphenyl)-2-phenoxy-1H-indole-3-carboximidamide;

1-(4-Hydroxy-phenyl)-2-phenyl-1H-indole-3-carboxylic acid;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(3-fluoro-4-hydroxy-phenyl)-1H-indole-3-carboxylic acid;

2-(3,5-Dimethyl-isoxazol-4-yl)-1-(2-fluoro-4-hydroxy-phenyl)-1H-indole-3-carboxylic acid;

1-(2,3-Difluoro-4-hydroxy-phenyl)-2-(3,5-dimethyl-isoxazol-4-yl)-1H-indole-3-carboxylic acid;

1-(4-Hydroxy-phenyl)-2-((Z)-propenyl)-1H-indole-3-carboxylic acid;

1-(4-Hydroxy-phenyl)-2-((E)-propenyl)-1H-indole-3-carboxylic acid;

1-(4-Hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carboxylic acid;

1-(4-Hydroxy-phenyl)-2-(2-methyl-allyl)-1H-indole-3-carboxylic acid;

1-(4-Hydroxy-phenyl)-2-((Z)-1-methyl-propenyl)-1H-indole-3-carboxylicacid;

1-(3-Fluoro-4-hydroxy-phenyl)-2-thiophen-3-yl-1H-indole-3-carboxylic acid;

1-(3-Fluoro-4-hydroxy-phenyl)-2-thiophen-2-yl-1H-indole-3-carboxylic acid;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(1-methyl-1H-pyrrol-2-yl)-1H-indole-3-carboxylic acid;

1-(3-Fluoro-4-hydroxy-phenyl)-2-(3-methyl-thiophen-2-yl)-1H-indole-3-carboxylic acid;

2-Bromo-1-(4-hydroxy-phenyl)-1H-indole-3-carboxylic acid;

1-(4-Hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carboxylic acid;

2,7-Dibromo-1-(2,5-difluoro-4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-Bromo-4-fluoro-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

4-Fluoro-1-(4-hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carbonitrile;

4-Fluoro-1-(4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-4-fluoro-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

4-Fluoro-1-(4-hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carbonitrile;

5-Fluoro-1-(4-hydroxy-phenyl)-2-phenyl-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-5-fluoro-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

5-Fluoro-1-(4-hydroxy-phenyl)-2-pyrrol-1-yl-1H-indole-3-carbonitrile;

5-Fluoro-1-(4-hydroxy-phenyl)-2-(2-methyl-prop-1-enyl)-1H-indole-3-carbonitrile;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-5-fluoro-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-4-fluoro-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-5-fluoro-N′-hydroxy-1-(4-hydroxyphenyl)-2-(2-methylprop-1-enyl)-1H-indole-3-carboximidamide;

4-Chloro-2-(3,5-dimethyl-isoxazol-4-yl)-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(3,5-dimethylisoxazol-4-yl)-4,5-difluoro-1-(4-hydroxyphenyl)-1H-indole-3-carbonitrile;

2-(4-cyano-1-methyl-1H-pyrazol-5-yl)-4-fluoro-1-(4-hydroxyphenyl)-1H-indole-3-carbonitrile;

2-(3,5-dimethylisoxazol-4-yl)-5-fluoro-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

2-(3,5-dimethylisoxazol-4-yl)-5-fluoro-1-(4-hydroxyphenyl)-1H-indole-3-carboxamide;

2-Bromo-7-fluoro-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-7-fluoro-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

2-(3,5-Dimethyl-isoxazol-4-yl)-4,7-difluoro-1-(4-hydroxy-phenyl)-1H-indole-3-carbonitrile;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-4,7-difluoro-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

1-(2,5-Difluoro-4-hydroxy-phenyl)-2-(3,5-dimethyl-isoxazol-4-yl)-1H-indole-3-carbonitrile;

1-(3-bromo-4-hydroxyphenyl)-2-(2-methylprop-1-enyl)-1H-indole-3-carboxamide;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-1-(2,5-difluoro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-1-(3,5-difluoro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-1-(3-fluoro-4-hydroxyphenyl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-1-(3-chloro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-N′-hydroxy-1H-indole-3-carboximidamide;

2-(3,5-dimethylisoxazol-4-yl)-1-(2-fluoro-4-hydroxyphenyl)-1H-indole-3-carboxamide;

(Z)-1-(2,3-difluoro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-N′-hydroxy-1H-indole-3-carboximidamide;

1-(2,3-difluoro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-1H-indole-3-carboxamide;

1-(2-fluoro-4-hydroxyphenyl)-2-(3-methylthiophen-2-yl)-1H-indole-3-carbonitrile;

2-(3,5-dimethyl-1H-pyrazol-4-yl)-1-(2-fluoro-4-hydroxyphenyl)-1H-indole-3-carbonitrile;

1-(2-fluoro-4-hydroxyphenyl)-2-(1-methyl-1H-pyrazol-5-yl)-1H-indole-3-carbonitrile;

1-(2-fluoro-4-hydroxyphenyl)-2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

1-(2-fluoro-4-hydroxyphenyl)-2-(3-(trifluoromethyl)-1H-pyrazol-4-yl)-1H-indole-3-carbonitrile;

(Z)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(3-methylthiophen-2-yl)-1H-indole-3-carboximidamide;

(Z)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1-methyl-1H-pyrazol-5-yl)-1H-indole-3-carboximidamide;

(Z)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-3-carboximidamide;

(Z)-4-fluoro-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1-methyl-1H-pyrazol-5-yl)-1H-indole-3-carboximidamide;

(Z)-4-fluoro-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-3-carboximidamide;

(Z)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-4- fluoro-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-4-fluoro-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(3-methylthiophen-2-yl)-1H-indole-3-carboximidamide;

(Z)-2-(3,5-dimethylisoxazol-4-yl)-4- fluoro-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(3-methylthiophen-2-yl)-1H-indole-3-carboximidamide;

(Z)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1-methyl-1H-pyrazol-5-yl)-1H-indole-3-carboximidamide;

(Z)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1H-indole-3-carboximidamide;

(Z)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-1-(2-fluoro-4-hydroxyphenyl)-N′-hydroxy-1H-indole-3-carboximidamide;

methyl 2-(3,5-dimethylisoxazol-4-yl)-1-(2-fluoro-4-hydroxyphenyl)-1H-indole-3-carbimidate;

2-(3,5-dimethylisoxazol-4-yl)-1-(3-fluoro-4-hydroxyphenyl)-1H-indole-3-carboxamide;

1-(2,5-difluoro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-1H-indole-3-carboximidamide;

2-(3,5-dimethylisoxazol-4-yl)-1-(3-fluoro-4-hydroxyphenyl)-1H-indole-3-carboximidamide;

(Z)-1-(3-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1H-pyrrol-1-yl)-1H-indole-3-carboximidamide;

1-(3-fluoro-4-hydroxyphenyl)-2-(1H-pyrrol-1-yl)-1H-indole-3-carboxamide;

(Z)-1-(2,3-difluoro-4-hydroxyphenyl)-N′-hydroxy-2-(1H-pyrrol-1-yl)-1H-indole-3-carboximidamide;

1-(2,3-difluoro-4-hydroxyphenyl)-2-(1H-pyrrol-1-yl)-1H-indole-3-carboxamide;

(Z)-2-(2,5-dimethyl-1H-pyrrol-1-yl)-1-(3-fluoro-4-hydroxyphenyl)-N′-hydroxy-1H-indole-3-carboximidamide;

(Z)-1-(3-fluoro-4-hydroxyphenyl)-N′-hydroxy-2-(2-methyl-1H-pyrrol-1-yl)-1H-indole-3-carboximidamide;

1-(3,5-difluoro-4-hydroxyphenyl)-2-(3,5-dimethylisoxazol-4-yl)-1H-indole-3-carboxamide; and

(Z)-2-(3,5-dimethylisoxazol-4-yl)-6-fluoro-N′-hydroxy-1-(4-hydroxyphenyl)-1H-indole-3-carboximidamide;

or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt thereof.

14. A pharmaceutical composition which comprises a compound as claimed in claim 1 , together with a pharmaceutically acceptable carrier.

15. A pharmaceutical composition which comprises a compound as claimed in claim 13 , together with a pharmaceutically acceptable carrier.