IP Library Granted Patent US 8,367,737
Granted Patent B2
US 8,367,737 · App. 12/595,278 · Granted Feb 5, 2013

Method of using biothionol and biothionol-like compounds as anti-angiogenic agents

Inventors: Zhican Qu (Birmingham, AL); Anshu M. Roy (Rajasthan, IN); Subramaniam Ananthan (Birmingham, AL)
Assignee: Southern Research Institute
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Quick Facts
Patent No.
US 8,367,737
App. No.
12/595,278
Granted
Feb 5, 2013
Kind
B2
Abstract

The present disclosure relates generally to treating or preventing diseases associated with angiogenesis by administering to a patient certain compounds found to inhibit or substantially reduce angiogenesis. Compounds employed according to the present disclosure exhibit good anti-angiogenic activity as well as demonstrate a prophylactic effect for preventing and substantially reducing angiogenesis. Examples of such compounds include Ritanserin, Amiodarone, Terfenadinc, Perphenazine, Bithionol, and Clomipramine.

Claims (3)

1. A method for inhibiting the growth or metastasis of a solid tumor comprising administering a therapeutically effective amount of bithionol to a patient in need thereof and inhibiting the growth or metastasis of the solid tumor.

2. The method of claim 1 , wherein the administration of bithionol inhibits the growth of the solid tumor.

3. The method of claim 1 , wherein the administration of bithionol inhibits metastasis of the solid tumor.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 9, 2024
From: SOUTHERN RESEARCH INSTITUTE
To: NATIONAL INSTITUTES OF HEALTH
Reel/Frame 069521/0584 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 29, 2010
From: QU, ZHICAN; ROY, ANSHU M.; ANANTHAN, SUBRAMANIAM
To: SOUTHERN RESEARCH INSTITUTE
Reel/Frame 024311/0932 →
Continuity (2)
Provisional Application 60911645 · Apr 13, 2007
Related Publication 20100204338A1 · Aug 12, 2010