Methods of treating emesis using growth hormone secretagogues
The present invention relates to methods of treating emesis by administering to the subject an effective amount of a growth hormone secretagogue compound or a pharmaceutically acceptable salt thereof.
1. A method of treating emesis induced by cancer chemotherapy or post-operative nausea and vomiting in a subject comprising administering to a subject in need of such treatment, a treatment effective amount of a compound of structure III, or a pharmaceutically acceptable salt thereof:
2. The method of claim 1 , wherein said emesis is post-operative nausea and vomiting.
3. The method of claim 1 , wherein said emesis is induced by cancer chemotherapy.
4. The method of claim 1 , wherein the compound is administered at an amount of from 1 to 150 mg/day.
5. The method of claim 1 , wherein the compound is administered at an amount of from 10 to 100 mg/day.
6. The method of claim 1 , wherein the compound is administered at an amount of about 50 mg/day.
7. The method of claim 1 wherein the compound is administered in an amount of about: 200 mcg, 300 mcg, 400 mcg, 500 mcg, 1 mg, 1.25 mg, 1.5 mg, 2.0 mg, 2.5 mg, 3.0 mg, 3.5 mg, 4.0 mg, 4.5 mg, 5 mg, 10 mg, 20 mg, 30 mg, 40 mg, or 50 mg.
8. The method of claim 1 , wherein the subject is receiving cancer chemotherapy.
9. The method of claim 1 , wherein said treatment is defined by an increase in the period of latency of an emetic episode in a subject.
10. The method of claim 1 , wherein said treatment is defined based on a reduction in the number of episodes of nausea and vomiting.
11. A method of increasing the period of latency in a subject prior to an episode of emesis wherein the episode of emesis is induced by cancer chemotherapy or wherein the episode of emesis is post-operative, comprising administering to a subject in need of such treatment, a treatment effective amount of a compound of structure III, or a pharmaceutically acceptable salt thereof:
12. The method of claim 11 , wherein the compound is administered in an amount of from 1 mg to 150 mg.
13. The method of claim 11 , wherein the compound is administered in an amount of from 10 mg to 100 mg.
14. A method of reducing the number of episodes of retching in a subject induced by cancer chemotherapy or post-operative nausea and vomiting, comprising administering to a subject in need of such treatment, a treatment effective amount of a compound of structure III, or a pharmaceutically acceptable salt thereof:
15. The method of claim 14 , wherein the compound is administered in an amount of from 1 mg to 150 mg.
16. The method of claim 14 , wherein the compound is administered in an amount of from 10 mg to 100 mg.