Method of continuous capture verification in cardiac resynchronization devices
In bi-ventricular pacing devices (including CRT devices) analysis of myocardial electrogram signals in one ventricle (e.g., a left ventricle, or “LV”) can be used to infer capture or loss-of-capture (LOC) of an earlier stimulus pulse in the same ventricle, on a continuous (every pacing cycle), triggered, aperiodic and/or periodic basis. Rather than using an evoked-response principle as has been the basis of capture detection in prior art and other systems, a principle employed via the present invention uses evidence of inter-ventricular conduction (i.e., from the opposite chamber) and/or atrio-ventricular conduction as evidence of LOC, since a non-capturing pacing stimulus provided to a first chamber will allow the myocardial tissue of the first chamber to remain non-refractory and thus inter-ventricular and atrio-ventricular wavefront propagation and conduction can commence and be detected thereby revealing whether LOC has occurred.
1. A method of pacing, comprising:
disposing first and second electrodes in electrical communication with first and second ventricles of a patient's heart, respectively;
delivering pacing stimuli to the first and second ventricles at approximately the same time;
employing the second electrode to detect depolarizations of the second ventricle following delivery of the pacing stimuli;
in the event that a depolarization is detected by the second electrode within a first time interval following delivery of the pacing stimuli declaring capture of the second ventricle;
in the event that a depolarization is detected by the second electrode within a second time interval following the first time interval, declaring loss-of-capture (LOC) of the second ventricle;
employing the first electrode to detect depolarizations of the first ventricle following delivery of the pacing stimuli;
in the event that a depolarization is detected by the first electrode within a third time interval following delivery of the pacing stimuli declaring capture of the first ventricle; and
in the event that a depolarization is detected by the first electrode within a fourth time interval following the first time interval, declaring loss-of-capture (LOC) of the second ventricle; and
wherein the second and fourth time intervals are the same duration.
2. The method of claim 1 , wherein the first time interval extends until about 55 milliseconds following delivery of the pacing stimuli.
3. A method of pacing, comprising:
disposing first and second electrodes in electrical communication with first and second chambers of a patient's heart, respectively;
delivering pacing stimuli to the first and second chambers at approximately the same time;
employing the second electrode to detect depolarizations of the second chamber following delivery of the pacing stimuli;
in the event that a depolarization is detected by the second electrode within a first time interval following delivery of the pacing stimuli declaring capture of the second chamber;
in the event that a depolarization is detected by the second electrode within a second time interval following the first time interval, declaring loss-of-capture (LOC) of the second chamber;
employing the first electrode to detect depolarizations of the first chamber following delivery of the pacing stimuli;
in the event that a depolarization is detected by the first electrode within a third time interval following delivery of the pacing stimuli declaring capture of the first chamber; and
in the event that a depolarization is detected by the first electrode within a fourth time interval following the first time interval, declaring loss-of-capture (LOC) of the second chamber; AND
wherein the second and fourth time intervals are the same duration.
4. The method of claim 3 , wherein the first time interval extends until about 55 milliseconds following delivery of the pacing stimuli.