Granted Patent
B2
US 8,420,614 · App. 12/527,307 · Granted Apr 16, 2013
Compositions and methods for inhibiting or reversing fibrotic disorders
Inventors:
Livingston Van De Water (Old Chatham, NY); Ganary Dabiri (Albany, NY); Christopher E. Turner (Chittenago, NY)
Assignee:
Albany Medical College
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Abstract
The present invention provides compositions and methods for inhibiting or reversing fibrotic disorders by administering a Hic-5 antagonist to a mammal in need thereof. The invention also includes methods for screening compounds to identify Hic-5 antagonists useful in inhibiting or reversing fibrotic disorders.
Claims (2)
1. A method for inhibiting or reversing a fibrotic disorder in a mammalian subject, the method comprising:
administering a therapeutically effective amount of a Hic-5 siRNA that has the nucleotide sequence of SEQ ID NO:1 or SEQ ID NO:2.
Assignments (4)
CONFIRMATORY LICENSE
Recorded May 4, 2015
From: ALBANY MEDICAL COLLEGE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035571/0110 →
CORRECTIVE ASSIGNMENT TO CORRECT THE NAME OF ASSIGNOR LIVINGSTON VAN DE WATER. LAST NAME SHOULD BE: VAN DE WATER NO MIDDLE NAME. PREVIOSLY RECORDED ON REEL 029234 FRAME 0671. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT.
Recorded Jan 4, 2013
From: VAN DE WATER, LIVINGSTON; DABIRI, GANARY
To: ALBANY MEDICAL COLLEGE
Reel/Frame 029612/0928 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 2, 2012
From: DE WATER, LIVINGSTON VAN; DABIRI, GANARY
To: ALBANY MEDICAL COLLEGE
Reel/Frame 029234/0671 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Nov 2, 2012
From: TURNER, CHRISTOPHER E.
To: THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK
Reel/Frame 029234/0689 →
Continuity (2)
Provisional Application
60890210
· Feb 16, 2007