Pyrazolo (3, 4-B) pyridine derivatives as phosphodiesterase inhibitors

1. A compound having the structure of Formula I:

or its pharmaceutically acceptable salts, wherein

R 1 and R 2 independently are hydrogen, aryl, heteroaryl, —COR 4 , —S(O) m R 4 (wherein R 4 is hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or heterocyclyl and m is an integer from 0-2),

 wherein X is —O—, S(O) m (wherein m is an integer from 0-2), C(═O), C═NOH, CR f R q (wherein R f and R q independently are hydrogen, hydroxy, carboxy or cyano) or NR 5 {wherein R 5 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl, —COR 4 , —S(O) m R 4 , —COOR 4 or —CONR 4 R′ 4 (wherein R 4 and R′ 4 independently are hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or heterocyclyl and m is an integer from 0-2)};

R 3 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, aralkyl, aralkenyl, cycloalkylalkyl, heterocyclyl, heteroaryl, heterocyclylalkyl or heteroarylalkyl;

M is a 3-7 membered saturated, partially saturated or unsaturated ring containing carbon atoms wherein one or more carbon atoms optionally are replaced by heteroatoms selected from O, S(O) m {wherein m is an integer from 0-2} or NR 6 {wherein R 6 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, heteroaryl, heterocyclyl, —COR 4 , —S(O) m R 4 , —COOR 4 or —CONR 4 R′ 4 (wherein R 4 and R′ 4 independently are hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl or heterocyclyl and m is an integer from 0-2)}, or one or more carbon atoms optionally are substituted with oxo, halogen, spiro-attached heterocyclyl, hydroxy, cyano, alkyl, heteroaryl, heteroarylalkyl, —(CH 2 ) m NR 4 R′ 4 , —(CH 2 ) m OR 4 , —(CH 2 ) m CONR 4 R′ 4 , —(CH 2 ) m NR 4 COR 4 , or —(CH 2 ) m COOR 4 (wherein m, R 4 and R′ 4 are the same as defined above).

2. A compound, which is selected from

N-cyclohexyl-1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 1),

N-cyclohexyl-1-ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 2),

N-cyclohexyl-1-ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 3),

N-cyclohexyl-1-ethyl-5-(1-oxa-7-thia-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 4),

N-cyclohexyl-1-ethyl-5-(7-oxido-1-oxa-7-thia-2-azaspiro[4.4]non-2-en-3-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 5),

N-cyclohexyl-1-ethyl-5-(5-oxa-2-thia-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 6),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 7),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 8),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 9),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanol (Compound No. 10),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanol (Compound No. 11),

N-cyclohexyl-5-(1,7-dioxa-2-azaspiro[4.4]non-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 12),

4-{[1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanol (Compound No. 13),

N-cyclohexyl-5-(2,2-dioxido-5-oxa-2-thia-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 14),

tert-Butyl 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2,8-diazaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 15),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanone (Compound No. 16),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanone oxime (Compound No. 17),

N-cyclohexyl-1-ethyl-5-(1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine hydrochloride salt (Compound No. 18),

4-{[1-Ethyl-5-(1,9,12-trioxa-2-azadispiro[4.2.4.2]tetradec-2-en-3-yl)-1H -pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanol (Compound No. 19),

4-{[1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanone (Compound No. 20),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanone (Compound No. 21),

3-{1-Ethyl-4-[(4-hydroxycyclohexyl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-en-8-one (Compound No. 22),

N-cyclohexyl-5-[8-(2,2-dimethylpropanoyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 23),

N-cyclohexyl-1-ethyl-5-{8-[(trifluoromethyl)sulfonyl]-1-oxa-2,8-diazaspiro[4.5]dec -2-en-3-yl}-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 24),

N-cyclohexyl-1-ethyl-5-[8-(ethyl sulfonyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 25),

N-cyclohexyl-5-[8-(cyclopropylmethyl)-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 26),

5-(8-Acetyl-1-oxa-2,8-diazaspiro[4.5]dec-2-en-3-yl)-N-cyclohexyl-1-ethyl-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 27),

N-cyclohexyl-5-(2,5-dioxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 28),

1-(4-Methoxybenzyl)-N-(3-methoxyphenyl)-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 41),

(cis or trans) 3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 42),

(trans or cis) 3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 43),

5-[2-(Benzyloxy)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 44),

(cis or trans) 3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 45),

3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one (Compound No. 46),

7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carbonitrile (Compound No. 47),

7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carbonitrile (Compound No. 48),

5-(5-Oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 49),

1-Methyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 50),

5-(1-Oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 51),

1-Ethyl-N-[1-(methylsulfonyl)piperidin-4-yl]-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 52),

N-(1-acetylpiperidin-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 53),

N-(1-acetylpiperidin-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 54),

1-(4-Methoxybenzyl)-N-(tetrahydro-2H-pyran-4-yl)-5-(1,9,12-trioxa-2-azadispiro[4.2.4.2]tetradec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 55),

5-(5-Oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 56),

7-[1-(4-Methoxybenzyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carbonitrile (Compound No. 57),

1-(Cyclopropylmethyl)-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H -pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 58),

1-Butyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 59),

1-(1-Methylethyl)-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 60),

5-(5-Oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-propyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 61),

5-(1-Oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1-(2,2,2-trifluoroethyl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 62),

N-(1-Cyclopentylpiperidin-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 63),

N-(1-butylpiperidin-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-107 pyrazolo[3,4-b]pyridin-4-amine (Compound No. 64),

2-(4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}piperidin-1-yl)ethanol (Compound No. 65),

N-[1-(cyclopropylmethyl)piperidin-4-yl]-1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 66),

1-Ethyl-N-[1-(1-methylethyl)piperidin-4-yl]-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 67),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(1-propylpiperidin-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 68),

N-(1-cyclopentylpiperidin-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 69),

1-Ethyl-N-[1-(1-methylethyl)piperidin-4-yl]-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 70),

1-Cyclopentyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 71),

1-(Cyclopropylmethyl)-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H -pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 72),

1-(1-Methylethyl)-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl) -1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 73),

5-(1-Oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-propyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 74),

1-Cyclopentyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 75),

1-(Cyclopropylmethyl)-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-131 pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 76),

1-(1-Methylethyl)-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 77),

5-(1-Oxa-2-azaspiro[4.4]non-2-en-3-yl)-1-propyl-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 78),

1-Methyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 79),

N-Cyclohexyl-1-ethyl-5-(1,9,12-trioxa-2-azadispiro[4.2.4.2]tetradec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 80),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one (Compound No. 81),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-piperidin-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 82),

Tert-butyl 4-{[1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}piperidine-1-carboxylate (Compound No. 83),

1-Ethyl-N-(1-ethylpiperidin-4-yl)-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 84),

1-Ethyl-N-(1-methylpiperidin-4-yl)-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 85),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-piperidin-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 86),

Tert-butyl 4-{[1-ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}piperidine-1-carboxylate (Compound No. 87),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(1-propylpiperidin-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 88),

N-[1-(cyclopropylmethyl)piperidin-4-yl]-1-ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 89),

2-(4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}piperidin-1-yl)ethanol (Compound No. 90),

N-cyclohexyl-1-(4-methoxybenzyl)-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 91),

3-[1-(4-Methoxybenzyl)-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-one (Compound No. 92),

7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-ol (Compound No. 93),

1-Ethyl-N-(3-methoxyphenyl)-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 94),

(cis or trans) 3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 95),

(trans or cis) 3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 96),

5-{2-[(Benzyloxy)methyl]-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl}-1-(4-methoxybenzyl) -N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 97),

(trans or cis) 3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 98),

7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 99),

1-(4-Methoxybenzyl)-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 100),

5-(1-Oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 101),

1-(4-Methoxybenzyl)-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 102),

5-{2-[(Benzyloxy)methyl]-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl}-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 103),

{7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}methanol (Compound No. 104),

7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 105),

cis or trans 7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 106),

(trans or cis) 7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 107),

(cis or trans) 3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 108),

(trans or cis) 3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 109),

1-(4-Methoxybenzyl)-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 110),

5-[2-(Benzyloxy)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-(4-methoxybenzyl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 111),

Ethyl (cis or trans) 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 112),

Ethyl (trans or cis) 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 113),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine ((Compound No. 114),

3-{[1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 115),

3-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 116),

3-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 117),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile (Compound No. 118),

3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 119),

3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile (Compound No. 120),

7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-ol (Compound No. 121),

7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-ol (Compound No. 122),

7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 123),

7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 124),

7-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 125),

7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-ethyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 126),

N-Ethyl-7-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 127),

5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 128),

5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-cyclohexyl-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 129),

N-{7-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}acetamide (Compound No. 130),

N-{7-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}acetamide (Compound No. 131),

4-{[1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 132),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 133),

4-{[1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 134),

4-{[5-(2-Cyano-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 135),

1-Ethyl-3-methyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 136),

1-Ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 137),

1-Ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 138),

7-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carbonitrile (Compound No. 139),

N-Cyclohexyl-1-ethyl-3-methyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 140),

7-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carbonitrile (Compound No. 141),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-1-oxa-2-azaspiro[4.5]dec-2-en-8-amine (Compound No. 142),

4-{[5-(2-Cyano-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 143),

4-{[1-Ethyl-5-(2-hydroxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 144),

4-{[1-Ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 145),

4-{[1-Ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 146),

4-{[1-Ethyl-5-(8-hydroxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 147),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 148),

3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 149),

4-{[5-(8-Carbamoyl-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 150),

3-{[5-(8-Carbamoyl-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b.]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 151),

3-{1-Ethyl-4-[(3-hydroxycyclobutyl)amino]-1H-pyrazolo[3,4-b]pyridin-5-yl}-N-methyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 152),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 153),

3-[1-Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 154),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-N-methyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 155),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-N-methyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 156),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-3-methyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 157),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 158),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 159),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 160),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 161),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 162),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 163),

3-{-4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 164),

3-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 165),

3-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 166),

3-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile (Compound No. 167),

7-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 168),

7-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-ol (Compound No. 169),

7-[1-Ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 170),

5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-3-methyl-N-(tetrahydro-2H -pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 171),

3-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-ol (Compound No. 172),

3-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carbonitrile (Compound No. 173),

3-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 174),

7-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 175),

7-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-ol (Compound No. 176),

7-[4-(Cyclohexylamino)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-methyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 177),

5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-cyclohexyl-1-ethyl-3-methyl-1H -pyrazolo[3,4-b]pyridin-4-amine (Compound No. 178),

4-{[1-Ethyl-3-methyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 179),

4-{[1-Ethyl-5-(8-hydroxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 180),

3-{[1-Ethyl-3-methyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 181),

3-{[1-Ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 182),

3-{[1-Ethyl-3-methyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 183),

3-{[5-(2-Cyano-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 184),

3-{[5-(2-Cyano-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-3-methyl-1H-pyrazolo [3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 185),

3-{[1-Ethyl-5-(8-hydroxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 186),

3-{[1-Ethyl-5-(8-hydroxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 187),

3-{[1-Ethyl-5-(2-hydroxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 188),

3-{[1-Ethyl-5-(2-hydroxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 189),

5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 190),

5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 191),

N-(7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)acetamide (Compound No. 192),

N-(7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)acetamide (Compound No. 193),

N-(7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)propanamide (Compound No. 194),

N-(7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)propanamide (Compound No. 195),

3-{[5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 196),

3-{[5-(2-Amino-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclobutanecarboxylic acid (Compound No. 197),

3-({5-[2-(Acetylamino)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclobutanecarboxylic acid (Compound No. 198),

3-({5-[2-(Acetylamino)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclobutanecarboxylic acid (Compound No. 199),

3-({1-Ethyl-5-[2-(propanoylamino)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclobutanecarboxylic acid (Compound No. 200),

3-({1-Ethyl-3-methyl-5-[2-(propanoylamino)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H -pyrazolo[3,4-b]pyridin-4-yl}amino)cyclobutanecarboxylic acid (Compound No. 201),

N-ethyl-7-[1-ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b)]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 202),

N-{7-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}propanamide (Compound No. 203),

N-{7-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}propanamide (Compound No. 204),

N-{7-[1-ethyl-3-methyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}propanamide (Compound No. 205),

4-{[5-(8-Amino-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 206),

4-{[5-(8-Amino-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 207),

4-({5-[8-(Acetylamino)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 208),

4-({5-[8-(Acetylamino)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 209),

4-({1-Ethyl-3-methyl-5-[8-(propanoylamino)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 210),

4-({1-Ethyl-5-[8-(propanoylamino)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 211),

7-{4-[(4-Carboxycyclohexyl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 212),

7-{4-[(4-Carboxycyclohexyl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 213),

4-{[5-(2-Carbamoyl-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 214),

4-{[5-(2-Carbamoyl-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 215),

4-({1-Ethyl-3-methyl-5-[2-(methylcarbamoyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 216),

4-({1-Ethyl-5-[2-(methylcarbamoyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 217),

4-({1-Ethyl-5-[2-(ethylcarbamoyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 218),

4-({1-Ethyl-5-[2-(ethylcarbamoyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-3-methyl-1H-pyrazolo [3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 219),

3-{4-[(4-Carboxycyclohexyl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 220),

3-{4-[(4-Carboxycyclohexyl)amino]-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylic acid (Compound No. 221),

4-{[5-(8-Carbamoyl-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-3-methyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 222),

4-({1-Ethyl-5-[8-(methylcarbamoyl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 223),

4-({1-Ethyl-3-methyl-5-[8-(methylcarbamoyl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 224),

4-({1-Ethyl-5-[8-(ethylcarbamoyl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-3-methyl-1H -pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 225),

4-({1-Ethyl-5-[8-(ethylcarbamoyl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 226),

4-{[1-Ethyl-5-(8-methoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 227),

4-{[5-(8-Ethoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}cyclohexanecarboxylic acid (Compound No. 228),

4-({1-Ethyl-5-[8-(2-hydroxyethoxy)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-yl}amino)cyclohexanecarboxylic acid (Compound No. 229),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 230),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-pyridin-3-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 231),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-pyridin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 232),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-pyrazin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 233),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-pyrimidin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 234),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-1,2,4-triazin-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 235),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-1,3-thiazol-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 236),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-4H-1,2,4-triazol-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 237),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-2H-tetrazol-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 238),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-1H-tetrazol-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 239),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-pyrimidin-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 240),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 241),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-pyridin-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 242),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-pyridin-3-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 243),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-pyridin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 244),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-pyrimidin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 245),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-pyrimidin-5-yl-1H-523 pyrazolo[3,4-b]pyridin-4-amine (Compound No. 246),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-1,2,4-triazin-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 247),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-1,3-thiazol-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 248),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-4H-1,2,4-triazol-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 249),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-2H-tetrazol-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 250),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-1H-tetrazol-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 251),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-pyridin-3-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 252),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-pyridin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 253),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-pyrimidin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 254),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-pyrimidin-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 255),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-1,2,4-triazin-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 256),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-1H-tetrazol-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 257),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-2H-tetrazol-5-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 258),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-4H-1,2,4-triazol-4-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 259),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-1,3-thiazol-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 260),

1-Ethyl-N-furan-3-yl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 261),

1-Ethyl-N-furan-3-yl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 262),

1-Ethyl-N-furan-3-yl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 263),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-pyrazin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 264),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-pyrazin-2-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 265),

7-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carbonitrile (Compound No. 266),

7-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylic acid (Compound No. 267),

Methyl 7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylate (Compound No. 268),

Ethyl 7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylate (Compound No. 269),

tert-Butyl 7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxylate (Compound No. 270),

7-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-N-methyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 271),

7-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-N-ethyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 272),

N-cyclopropyl-7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H -pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 273),

7-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 274),

7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-cyclopropyl-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 275),

N-cyclopropyl-7-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-ene-2-carboxamide (Compound No. 276),

1-Ethyl-5-(8-methoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 277),

5-(8-Ethoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 278),

N-cyclohexyl-5-(8-ethoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 279),

N-cyclohexyl-1-ethyl-5-(8-methoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 280),

3-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-N-ethyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 281),

N-cyclopropyl-3-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H -pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 282),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-cyclopropyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 283),

N-cyclopropyl-3-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 284),

N-ethyl-3-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 285),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-N-ethyl-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxamide (Compound No. 286),

Ethyl 3-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 287),

Methyl 3-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 288),

tert-Butyl 3-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 289),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-(8-methoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 290),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-(8-ethoxy-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 291),

1-Ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-N-1,2,4-triazin-3-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 292),

1-Ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-1,2,4-triazin-3-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 293),

1-Ethyl-5-(1-oxa-2-azaspiro[4.5]dec-2-en-3-yl)-N-1,2,4-triazin-3-yl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 294),

1-Ethyl-5-(2-methoxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 295),

N-cyclohexyl-1-ethyl-5-(2-methoxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 296),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-(2-methoxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 297),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-(2-ethoxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 298),

N-cyclohexyl-5-(2-ethoxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 299),

5-(2-Ethoxy-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1-ethyl-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 300),

{7-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}methanol (Compound No. 301),

{7-{4-[(1,1-Dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)methanol (Compound No. 302),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-[2-(methoxymethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 303),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-[2-(ethoxymethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 304),

N-cyclohexyl-5-[2-(ethoxymethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 305),

5-[2-(Ethoxymethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-N-(tetrahydro-2H -pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 306),

1-Ethyl-5-[2-(methoxymethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-N-(tetrahydro-2H -pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 307),

N-cyclohexyl-1-ethyl-5-[2-(methoxymethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 308),

5-[2-(Aminomethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-N-cyclohexyl-1-ethyl-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 309),

5-[2-(Aminomethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1-ethyl-N-(tetrahydro-2H -pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 310),

5-[2-(Aminomethyl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-N-(1,1-dioxidotetrahydro -2H-thiopyran-4-yl)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 311),

N-[(7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)methyl]acetamide (Compound No. 312),

N-[(7-{4-[(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)amino]-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl}-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl)methyl]propanamide (Compound No. 313),

N-({7-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}methyl)propanamide (Compound No. 314),

N-({7-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}methyl)propanamide (Compound No. 315),

N-({7-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}methyl)acetamide (Compound No. 316),

N-({7-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-5-oxa-6-azaspiro[3.4]oct-6-en-2-yl}methyl)acetamide (Compound No. 317),

1-Ethyl-N-(tetrahydro-2H-pyran-4-yl)-5-[2-(1H-tetrazol-5-yl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 318),

N-cyclohexyl-1-ethyl-5-[2-(1H-tetrazol-5-yl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 319),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-[2-(1H-tetrazol-5-yl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 320),

1-Ethyl-N-(tetrahydro-2H-pyran-4-yl)-5-[8-(1H-tetrazol-5-yl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 321),

N-cyclohexyl-1-ethyl-5-[8-(1H-tetrazol-5-yl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 322),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-[8-(1H-tetrazol-5-yl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 323),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-[8-(2H-tetrazol-5-yl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 324),

N-cyclohexyl-1-ethyl-5-[8-(2H-tetrazol-5-yl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 325),

1-Ethyl-N-(tetrahydro-2H-pyran-4-yl)-5-[8-(2H-tetrazol-5-yl)-1-oxa-2-azaspiro[4.5]dec-2-en-3-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 326),

1-Ethyl-N-(tetrahydro-2H-pyran-4-yl)-5-[2-(2H-tetrazol-5-yl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 327),

N-cyclohexyl-1-ethyl-5-[2-(2H-tetrazol-5-yl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo [3,4-b]pyridin-4-amine (Compound No. 328),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-[2-(2H-tetrazol-5-yl)-5-oxa-6-azaspiro[3.4]oct-6-en-7-yl]-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 329),

Ethyl 3-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 330),

Ethyl 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 331),

Methyl 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 332),

Methyl 3-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 333),

tert-Butyl 3-[1-ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-1H-pyrazolo[3,4-b]pyridin -5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 334),

tert-Butyl 3-[4-(cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene-8-carboxylate (Compound No. 335),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-(5-oxa-6-azaspiro[3.4]oct-6-en-7-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 336),

N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1-ethyl-5-(1-oxa-2-azaspiro[4.4]non-2-en-3-yl)-1H-pyrazolo[3,4-b]pyridin-4-amine (Compound No. 337),

3-[4-(Cyclohexylamino)-1-ethyl-1H-pyrazolo[3,4-b]pyridin-5-yl]-1-oxa-2-azaspiro[4.5]dec-2-en-8-amine (Compound No. 338),

or its pharmaceutically acceptable salts, pharmaceutically acceptable, stereoisomers, tautomers, or racemates, thereof.

3. A pharmaceutical composition comprising a therapeutically effective amount of a compound as defined in claim 1 along with one or more of pharmaceutically acceptable carriers, excipients or diluents.

4. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 1 , along with one or more of pharmaceutically acceptable carriers, excipients or diluents and at least one other compound selected fromβ2-agonists, corticosteroids, leukotriene antagonists, 5-lipoxygenase inhibitors, chemokine inhibitors, p38 kinase inhibitors, anticholinergics, antiallergics, PAF (platelet activating factor) antagonists, EGFR (epidermal growth factor receptor) kinase inhibitors, muscarinic receptor antagonists or combination(s) thereof.

5. A compound of claim 1 for use in a method for treating, inhibiting, or suppressing CNS diseases in a mammal.

6. A compound of claim 1 for use in a method for the treatment, inhibition, or suppression of rejection of transplant, rheumatoid arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), asthma, psoriasis, allergic rhinitis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, colitis, pancreatitis, and cancer in a mammal.

7. A pharmaceutical composition comprising a therapeutically effective amount of a compound as defined in claim 2 along with one or more of pharmaceutically acceptable carriers, excipients or diluents.

8. A pharmaceutical composition comprising a therapeutically effective amount of a compound of claim 2 , along with one or more of pharmaceutically acceptable carriers, excipients or diluents and at least one other compound selected fromβ2-agonists, corticosteroids, leukotriene antagonists, 5-lipoxygenase inhibitors, chemokine inhibitors, p38 kinase inhibitors, anticholinergics, antiallergics, PAF (platelet activating factor) antagonists, EGFR (epidermal growth factor receptor) kinase inhibitors, muscarinic receptor antagonists or combination(s) thereof.

9. A compound of claim 2 for use in a method for treating, inhibiting, or suppressing CNS diseases in a mammal.

10. A pharmaceutical composition of claim 3 for use in a method for treating, inhibiting, or suppressing CNS diseases in a mammal.

11. A pharmaceutical composition of claim 4 for use in a method for treating, inhibiting, or suppressing CNS diseases in a mammal.

12. A compound of claim 2 for use in a method for the treatment, inhibition, or suppression of rejection of transplant, rheumatoid arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), asthma, psoriasis, allergic rhinitis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, colitis, pancreatitis, and cancer in a mammal.

13. A pharmaceutical composition of claim 3 for use in a method for the treatment, inhibition, or suppression of rejection of transplant, rheumatoid arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), asthma, psoriasis, allergic rhinitis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, colitis, pancreatitis, and cancer in a mammal.

14. A pharmaceutical composition of claim 4 for use in a method for the treatment, inhibition, or suppression of rejection of transplant, rheumatoid arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), asthma, psoriasis, allergic rhinitis, shock, atopic dermatitis, eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, colitis, pancreatitis, and cancer in a mammal.