IP Library Granted Patent US 8,426,387
Granted Patent B2
US 8,426,387 · App. 11/731,297 · Granted Apr 23, 2013

Treatments for cancer

Inventors: Stephen Carper (Las Vegas, NV); Susan Meacham (Henderson, NV)
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Quick Facts
Patent No.
US 8,426,387
App. No.
11/731,297
Granted
Apr 23, 2013
Kind
B2
Abstract

Phenyl boric acid and its salts and substituent derivatives (e.g., substituted phenyl) effectively inhibit the growth of several cancer cell lines and offers utility in the treatment/prevention of cancer. The material may be applied or injected into affected areas or applied topically, especially for the treatment of cervical cancer.

Claims (11)

1. A method for treatment of cancer in tissue within the prostate, breast or cervix comprising the ingestion, injection, infusion or application of an ingredient comprising a pharmaceutically active phenyl boric acid or salts of a phenyl boric acid to treat the affected tissue.

2. The method of claim 1 wherein the treatment is with an amount of ingredient that inhibits the growth of at least one cancer cell line.

3. The method of claim 1 wherein the ingredient comprises phenyl boric acid.

4. The method of claim 1 wherein the ingredient comprises a salt of phenyl boric acid.

5. The method of claim 1 wherein the ingredient comprises a phenyl boric acid in which the phenyl group has a single substitutent thereon and the phenyl ring of the phenyl boric acid constitutes at least 30% by weight of the phenyl group, and the single substitutent is selected from the group consisting of alkyl groups, substituted alkyl groups, ether groups, halogen, cyano groups, and carboxylic acid groups.

6. The method of claim 1 wherein the ingredient comprises a phenyl boric acid in which the phenyl group has 2 to 3 substitutents thereon, and the substitutents are selected from the group consisting of alkyl groups, substituted alkyl groups, ether groups, halogen, cyano groups, and carboxylic acid groups.

7. A method for treatment of cancer in tissue of the prostate, breast or cervix comprising the ingestion, injection, infusion or application of an ingredient comprising a pharmaceutically active agent consisting essentially of an aromatic group boric acid or an aromatic group boric acid salt to treat affected tissue in which a cancer cell line has been identified within the prostate, breast or cervix, wherein the aromatic boric acid has a formula (I):

wherein R is an aromatic group, and wherein any salt is a salt of an OH group on formula (I).

8. The method of claim 7 wherein R is a phenyl group and any substitutents are selected only from the group consisting of alkyl groups, substituted alkyl groups, ether groups, halogen, cyano groups, and carboxylic acid groups.

9. The method of claim 8 wherein the treatment is application to tissue identified as having a cancer cell line of cancer of the prostate, breast or cervix therein with an amount of the ingredient that inhibits the growth of the at least one cancer cell line identified as present in the tissue.

10. The method of claim 1 wherein the affected tissue comprises tissue in a cervix.

Assignments (2)
CONFIRMATORY LICENSE Recorded Dec 3, 2013
From: UNIVERSITY OF NEVADA, LAS VEGAS
To: US ARMY, SECRETARY OF THE ARMY
Reel/Frame 031750/0660 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 30, 2007
From: CARPER, STEPHEN; MEACHAM, SUSAN
To: BOARD OF REGENTS OF THE NEVADA SYSTEM OF HIGHER EDUCATION ON BEHALF OF THE UNIVERSITY OF NEVADA, LAS VEGAS
Reel/Frame 019170/0049 →
Continuity (2)
Provisional Application 60787903 · Mar 31, 2006
Related Publication 20070232569A1 · Oct 4, 2007