Coupled neuraxial mesoscopic desynchronization electrostimulation therapy (cNMDET) method

1. A method of Coupled Neuraxial Mesoscopic Desynchronization Electrostimulation Therapy (cNMDET) for applying ambulatory, non-invasive therapeutic electrostimulatory modalities, comprising mechanisms of action that are reparative, palliative and support adaptive recovery, in a preferred embodiment utilizing Coupled Neuraxial Transcutaneous Electrical Nerve Stimulation (cNTENS) and Coupled Neuraxial Transcranial Direct Stimulation (ctDCS n ), wherein the electrostimulatory modalities are configured to treat both acute and chronic pain, the method comprising;

placing a combination of at least two progressively sequenced electrodes on clinically targeted nerve areas, wherein the clinically targeted nerve areas establish a targeted neural pathway, the targeted neural pathway including at least one of;

a) central nervous system (CNS) sites,

b) underlying contributory clinicopathologic mechanisms of autonomic nervous system (ANS) sites and

c) clinically involved components of peripheral nervous system (PNS) sites;

wherein the CNS sites are comprised of brain regions, spinal cord regions and intervening structures;

applying therapeutic electrostimulation along a longitudinally coursing path of the targeted neural pathway,

wherein the longitudinally coursing path consists of targeted neural system pathways, and

wherein an additional combination of progressively sequenced electrostimulation electrodes further includes a patterned placement of the additional electrostimulation electrodes in an array of electrodes configured to treat involved joints, muscles, fascia, ligaments, tendons and areas involved in an inflammatory process.

2. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, the at least two progressively sequenced electrodes are further comprised of one or more stimulation channels including configurations of individually programmable electrode arrays with two electronically coupled electrode outputs per channel.

3. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, a ‘Neural Tube Technique’ (NTT) utilized in the priming, conditioning and treatment phases as may be specified by the controlling patient-specific treatment protocol is used

which is comprised of a configuration of the at least two coupled electrostimulatory electrodes to provide therapeutic electrostimulation transcutaneously

with one of the two coupled electrodes is placed at the central vertex (CZ) and the second placed according to the controlling patient-specific treatment protocol either to cutaneously approximate either the conus medullaris or alternatively the cauda equina region rsacral outflow area)

wherein an additional combination of progressively sequenced electrostimulation electrodes may be utilized as may be specified by the controlling patient-specific treatment protocol

to the CNS incorporating the region from the central vertex (CZ) to the cauda equina region (‘sacral outflow area’).

4. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, the therapeutic electrostimulation is provided longitudinally, by a coupled neuraxial field consisting of the CNS sites and the clinically involved components of the PNS in a varying coupled progressively sequenced manner according to a patient-specific controlling treatment protocol wherein the therapeutic electrostimulation modulation is applied along the longitudinal coursing path of at least one of the targeted neural pathway or a targeted segment or the entire length of the segment.

5. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, formulated therapeutic electrostimulation modulation is provided and is comprised of the pattered application of the electrostimulatory electrodes applied to the involved, muscles, fascia, ligaments, tendons, joints and areas of inflammatory processes as prescribed by a patient-specific controlling treatment protocol wherein at least one of one or more channels consisting of two electrodes per channel are electronically coupled or the array of electrodes is electronically coupled for programming across the array for the targeted treatment area or intervening neural pathway.

6. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, a patient-specific controlling treatment protocol contains a ‘priming phase’, wherein the ‘priming phase’ qualitatively prepares the targeted neural pathway(s) for an initiation of a promotion of an increased recruitment of processes of synaptic associative activity, and cooperativity primarily in the CNS sites with secondary influences in the PNS sites in preparation for a preconditioning treatment phase.

7. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, a patient-specific controlling treatment protocol contains a ‘preconditioning phase’ that establishes/promotes timed, therapeutic volume modulation which includes consideration of increased activity of a property of a process of associative activity and cooperativity and therapeutic electrostimulation of a targeted CNS site and to prescribed portions of the CNS, to achieve a threshold of an increased level of receptivity to the subsequent treatment phase.

8. The method for applying the therapeutic electrostimulatory modalities according to claim 1 wherein:

in a preferred embodiment, enhanced supportive neurometabolic capabilities are therapeutically induced resulting from the application of cNMDET.