Alloplastic injectable dermal filler and methods of use thereof

1. A composition comprising an alloplastic injectable suspension for use as a dermal filler comprising a biocompatible and pliable material and a physiologically acceptable suspending agent,

wherein the biocompatible and pliable material is a copolymer of phenylethyl acrylate and phenylethyl methacrylate,

wherein the phenylethyl acrylate and phenylethyl methacrylate copolymer is not absorbable or degradable by the body,

wherein the molar ratio between the substituent monomers in the copolymer is about 1:1000, about 1:100, about 1:10, about 1:9, about 1:8, about 1:7, about 1:6, about 1:5, about 1:4, about 1:3, about 1:2, or about 1:1 phenylethyl acrylate to phenylethyl methacrylate;

wherein said copolymer of phenylethyl acrylate and phenylethyl methacrylate is a solid,

wherein said solid is selected from the group consisting of a powder, a non-porous microbead, and a microsphere, and combinations thereof, and

wherein the solid comprises particles each having a diameter selected from the group consisting of about 10μ, to about 100μ; about 0.01μ to about 10μ, and about 0.01μ, to about 5μ, and combinations thereof.

2. The composition of claim 1 , wherein the physiologically acceptable suspending agent is resorbable.

3. The composition of claim 2 , wherein the physiologically acceptable suspending agent is selected from the group consisting of: a buffered physiological solution, cross-linked sodium hyaluronate, a non cross-linked sodium hyaluronate, collagen, isolated animal collagen, isolated bird collagen, and genetically engineered collagen.

4. The composition of claim 1 , wherein the composition further comprises a local anesthetic.

5. The composition of claim 1 , wherein the composition comprises a copolymer cross-linked with 1.4 butanediol diacrylate.

6. A method of making the composition of claim 1 , comprising admixing a biocompatible and pliable material with a physiologically acceptable suspending agent;

wherein the biocompatible and pliable material is a copolymer of phenylethyl acrylate and phenylethyl methacrylate

wherein the phenylethyl acrylate and phenylethyl methacrylate copolymer is not absorbable or degradable by the body,

wherein the molar ratio between the substituent monomers in the copolymer is about 1:1000, about 1:100, about 1:10, about 1:9, about 1:8, about 1:7, about 1:6, about 1:5, about 1:4, about 1:3, about 1:2, or about 1:1 phenylethyl acrylate to phenylethyl methacrylate;

wherein said copolymer of phenylethyl acrylate and phenylethyl methacrylate is a solid,

wherein said solid is selected from the group consisting of a powder, a non-porous microbead, and a microsphere, and combinations thereof, and

wherein the solid comprises particles each having a diameter selected from the group consisting of about 10μ, to about 100μ; about 0.01μ to about 10μ, and about 0.01μ, to about 5μ, and combinations thereof.

7. The method of claim 6 , wherein the physiologically acceptable suspending agent is resorbable.

8. The method of claim 7 , wherein the physiologically acceptable suspending agent is selected from the group consisting of a buffered physiological solution, cross-linked sodium hyaluronate, a non cross-linked sodium hyaluronate, collagen, isolated animal collagen, isolated bird collagen, and genetically engineered collagen.

9. The method of claim 6 , wherein the method further comprises adding a local anesthetic to the composition.

10. The method of claim 6 , wherein the method comprises cross-linking the copolymer with 1.4 butanediol diacrylate.

11. A method of augmenting soft tissue to provide long-term reduction of a skin defect, said method comprising injecting into the deep reticular dermis a composition according to claim 1 .

12. The method of claim 11 , comprising producing little immunologic response in the host tissue or no immunologic response in the host tissue.