Adjusted index of refraction of ocular replacement material
The present invention relates to a method of determining the IOL refractive index for an ocular replacement material for replacing tissue in the capsular bag comprising combining a neutral (non-correcting) reference refractive index (“NRRI”) of between 1.421 and 1.450 with a refractive index correction factor (“RICF”) ascertained by reference to the refractive power required to correct the patient's refractive error. The present invention also relates to methods of treating presbyopia, myopia and hyperopia using the above method.
1. A method of treating myopia, hyperopia, or presbyopia of a subject by replacing tissue in the subject's capsular bag comprising the steps of:
(a) determining a refractive index correction factor based on an estimate of the refractive power correction required, derived by measurement and/or examination of the subject's eye;
(b) determining the sum of (i) the refractive index correction factor of step (a) and (ii) a neutral reference refractive index of between 1.426 and 1.442;
(c) obtaining an ocular replacement material having a refractive index of the sum of (i) and (ii) determined in step (b); and
(d) replacing the tissue in the subject's capsular bag with the ocular replacement material.
2. A method according to claim 1 wherein the neutral reference refractive index is between 1.426 and 1.438.
3. A method according to claim 1 wherein the neutral reference refractive index is 1.427.
4. A method according to claim 1 in which the ocular replacement material is a polymer cured in situ from a cross-linkable siloxane macromonomer.
5. A method according to claim 1 , wherein the ocular replacement material is curable in situ.
6. A method according to claim 1 , wherein the ocular replacement material is shaped by the subject's capsular bag.
7. A method of producing an ocular replacement material for a subject having ametropia or presbyopia, comprising selecting an ocular replacement material having a refractive index determined by summing (i) a refractive index correction factor based on an estimate of the refractive power correction required, derived by measurement and/or examination of the subject's eye and (ii) a neutral reference refractive index of between 1.426 and 1.442.
8. A method according to claim 7 wherein the neutral reference refractive index is between 1.426 and 1.438.
9. A method according to claim 7 wherein the neutral reference refractive index is 1.427.
10. A method according to claim 7 in which the ocular replacement material is a polymer cured in situ from a cross-linkable siloxane macromonomer.
11. A method according to claim 7 , wherein the ocular replacement material is curable in situ.
12. A method according to claim 7 , wherein the ocular replacement material is shaped by the subject's capsular bag.
13. A method of treating myopia, hyperopia, or presbyopia of a subject by replacing tissue in the subject's capsular bag, comprising replacing the tissue in the subject's capsular bag with an ocular replacement material having a refractive index determined by summing (a) a neutral reference refractive index of between 1.426 and 1.442 and (b) a refractive index correction factor ascertained by reference to refractive power required to correct the patient's refractive error.
14. A method according to claim 13 wherein the neutral reference refractive index is between 1.426 and 1.438.
15. A method according to claim 13 wherein the neutral reference refractive index is 1.427.
16. A method according to claim 13 in which the ocular replacement material is a polymer cured in situ from a cross-linkable siloxane macromonomer.
17. A method according to claim 13 , wherein the ocular replacement material is curable in situ.
18. A method according to claim 13 , wherein the ocular replacement material is shaped by the subject's capsular bag.