Tricyclic compounds, compositions, and methods
The present invention is directed to compounds of Formula I: or salt thereof, which are modulators of the glucocorticoid receptor. The compounds and salts of the invention are useful in the treatment of conditions mediated by glucocorticoid receptor activity.
1. A method of treating a gastrointestinal disorder mediated by glucocorticoid receptor activity in a subject in need thereof comprising administering to the subject a compound of formula I:
wherein R 1 is —H or —P(O)(OH) 2 ;
or a salt thereof.
2. The method of claim 1 , wherein the gastrointestinal disorder is Crohn's disease.
3. A method of treating a rheumatic disorder mediated by glucocorticoid receptor activity in a subject in need thereof comprising administering to the subject a compound of formula I:
wherein R 1 is —H or —P(O)(OH) 2 ;
or a salt thereof.
4. A method of treating dermatitis mediated by glucocorticoid receptor activity in a subject in need thereof comprising administering to the subject a compound of formula I:
wherein R 1 is —H or —P(O)(OH) 2 ;
or a salt thereof.
5. The method of claim 4 , wherein the dermatitis is atopic dermatitis.
6. A method of treating collagen disease mediated by glucocorticoid receptor activity in a subject in need thereof comprising administering to the subject a compound of formula I:
wherein R 1 is —H or —P(O)(OH) 2 ;
or a salt thereof.
7. The method of claim 6 , wherein the collagen disease is systemic lupus erythematosus.
8. A method of treating obstructive or inflammatory airways disease mediated by glucocorticoid receptor activity in a subject in need thereof comprising administering to the subject a compound of formula I:
wherein R 1 is —H or —P(O)(OH) 2 ;
or a salt thereof.
9. The method of claim 8 , wherein the obstructive or inflammatory airways disease is chronic obstructive pulmonary disease (COPD).